The effect of histidine on mental fatigue and cognitive performance in subjects with high fatigue and sleep disruption scores

Our previous study reported that a dried bonito broth known in Japan as 'dashi' improved or ameliorated mood states, including fatigue, during the daily lives of human subjects. Histidine is an amino acid that is present in dried bonito broth, and we sought to evaluate whether histidine would affect feelings of fatigue in humans. We investigated the effects of histidine intake on the feeling of fatigue, mood states and mental task performance by performing a placebo-controlled, double-blind crossover trial. Twenty subjects with high fatigue and sleep disruption scores were asked to ingest histidine or a placebo every day for two weeks. The subjects' mood states were evaluated using the Profile of Mood States (POMS) scale and a visual analog scale (VAS) for eight feelings (fatigue, depression, carelessness, drowsiness, clear thinking, motivation, attentiveness and concentration). We also measured subjects' cognitive performance using the CogHealth test battery. The fatigue T-scores on the POMS test decreased significantly following histidine ingestion compared to placebo ingestion (p<0.05). After two weeks of histidine ingestion, the reaction time for the working memory task in the CogHealth test battery was significantly shorten compared to placebo ingestion. The VAS scores for clear thinking and for attentiveness were increased significantly following histidine ingestion compared to placebo ingestion (p<0.05). These results suggest that daily ingestion of histidine may ameliorate feelings of fatigue, increase performance during working memory tasks, and improve the clear thinking and attentiveness.

[1]  P. Maruff,et al.  Qualitative similarities in cognitive impairment associated with 24 h of sustained wakefulness and a blood alcohol concentration of 0.05% , 2003, Journal of sleep research.

[2]  T. Robbins,et al.  Translating cognition from animals to humans. , 2011, Biochemical pharmacology.

[3]  M. Kuroda,et al.  Effect of dried-bonito broth on mood states: a pooled analysis of four randomized controlled human trials. , 2008, Biomedical research.

[4]  M. D’Esposito.  Working memory. , 2008, Handbook of clinical neurology.

[5]  W. Pardridge.  Blood-brain barrier transport of nutrients. , 2009, Nutrition reviews.

[6]  E. Miller,et al.  An integrative theory of prefrontal cortex function. , 2001, Annual review of neuroscience.

[7]  Y. Ono,et al.  Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of histamine H1 receptor , 2009, Neuroscience Research.

[8]  I. Hindmarch,et al.  Effects of fexofenadine and hydroxyzine on brake reaction time during car‐driving with cellular phone use , 2005, Human psychopharmacology.

[9]  J. Rinne,et al.  Neuronal histamine deficit in Alzheimer's disease , 1997, Neuroscience.

[10]  Maarten A. S. Boksem,et al.  Mental fatigue: Costs and benefits , 2008, Brain Research Reviews.

[11]  M. Kuroda,et al.  Effect of dried-bonito broth on mental fatigue and mental task performance in subjects with a high fatigue score , 2007, Physiology & Behavior.

[12]  M. Tashiro,et al.  Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain. , 2002, Life sciences.

[13]  C. Ito.  The role of brain histamine in acute and chronic stresses. , 2000, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  M. Kuroda,et al.  Effect of dried-bonito broth intake on peripheral blood flow, mood, and oxidative stress marker in humans , 2008, Physiology & Behavior.

[15]  N. Schutte,et al.  Direct and indirect relationships between emotional intelligence and subjective fatigue in university students. , 2006, Journal of psychosomatic research.

[16]  S. Rapoport,et al.  Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier , 1987, Journal of neurochemistry.

[17]  S. Fuke,et al.  Taste-active components in some foods: A review of Japanese research , 1991, Physiology & Behavior.

[18]  W. Pardridge,et al.  Neutral amino acid transport at the human blood-brain barrier. , 1988, The Journal of biological chemistry.

[19]  M. Frese,et al.  Mental fatigue and the control of cognitive processes: effects on perseveration and planning. , 2003, Acta psychologica.

[20]  Takehiko Watanabe,et al.  Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat , 1999, Neuroscience Letters.

[21]  Andrus Viidik,et al.  Age and gender differences in negative affect—Is there a role for emotion regulation? , 2005 .

[22]  J. Tanaka,et al.  Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decar☐ylase as a marker , 1984, Brain Research.

[23]  H. Haas,et al.  The physiology of brain histamine , 2001, Progress in Neurobiology.

[24]  A. Harper,et al.  Atypical amino acids inhibit histidine, valine, or lysine transport into rat brain. , 1983, The American journal of physiology.

[25]  Paul Maruff,et al.  Fatigue‐related impairment in the speed, accuracy and variability of psychomotor performance: comparison with blood alcohol levels , 2005, Journal of sleep research.

[26]  Motohisa Kato,et al.  Blockage of histamine H1 receptor attenuates social isolation-induced disruption of prepulse inhibition: a study in H1 receptor gene knockout mice , 2005, Psychopharmacology.

[27]  L. Terenius,et al.  Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome , 1998, Pain.

[28]  Maria L. Thomas,et al.  Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose‐response study , 2003, Journal of sleep research.

[29]  Takayuki Obata,et al.  Effects of chewing in working memory processing , 2008, Neuroscience Letters.

[30]  T. Noguchi,et al.  Effect of Chicken Soup Intake on Mood States and Peripheral Blood Flow in Humans , 2009 .

[31]  H. Haas,et al.  The role of histamine and the tuberomamillary nucleus in the nervous system , 2003, Nature Reviews Neuroscience.

[32]  H. Koppeschaar,et al.  Effects of food on cortisol and mood in vulnerable subjects under controllable and uncontrollable stress , 2000, Physiology & Behavior.

[33]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.

[34]  Pharmacokinetics of stable isotopically labeled L-histidine in humans and the assessment of in vivo histidine ammonia lyase activities. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[35]  M. Hongo,et al.  Decreased histamine H1 receptor binding in the brain of depressed patients , 2004, The European journal of neuroscience.

[36]  C. Spann,et al.  Effect of sleep deprivation on medical resident and student cognitive function: A prospective study. , 2003, American journal of obstetrics and gynecology.

[37]  T. Watanabe,et al.  Studies on functional roles of the histaminergic neuron system by using pharmacological agents, knockout mice and positron emission tomography. , 2001, The Tohoku journal of experimental medicine.

[38]  Maarten A. S. Boksem,et al.  Effects of mental fatigue on attention: an ERP study. , 2005, Brain research. Cognitive brain research.

[39]  H. Haas,et al.  Histamine in the nervous system. , 2008, Physiological reviews.

[40]  M. Tashiro,et al.  The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies. , 2007, Pharmacology & therapeutics.

[41]  N. Okamura,et al.  Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors , 2007, Neuroscience Research.

[42]  S. Surani,et al.  Sleep Quality and Vigilance Differ Among Inpatient Nurses Based on the Unit Setting and Shift Worked , 2015, Journal of patient safety.

[43]  K. Miczek,et al.  Aggressive behavioral phenotypes in mice , 2001, Behavioural Brain Research.

[44]  M. D’Esposito,et al.  The neural basis of the central executive system of working memory , 1995, Nature.

[45]  L. Arnold.  Understanding fatigue in major depressive disorder and other medical disorders. , 2008, Psychosomatics.

[46]  H. Ohtsu,et al.  Anatomical, Physiological, and Pharmacological Characteristics of Histidine Decarboxylase Knock-Out Mice: Evidence for the Role of Brain Histamine in Behavioral and Sleep–Wake Control , 2002, The Journal of Neuroscience.

[47]  M Schwaiger,et al.  Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions. , 2000, The Journal of investigative dermatology.