An overview of cyberknife radiosurgery

Stereotactic radiosurgery is a non-invasive procedure that utilizes precisely targeted radiation as an ablative surgical tool. Conventional radiosurgery devices, such as the Gamma Knife, rely upon skeletally attached stereotactic frames to immobilize the patient and precisely determine the 3D spatial position of a tumor. A relatively new instrument, the CyberKnife (Accuray, Inc., Sunnyvale, CA), makes it possible to administer radiosurgery without a frame. The CyberKnife localizes clinical targets using a very accurate image-to-image correlation algorithm, and precisely cross-fires high-energy radiation from a lightweight linear accelerator by means of a highly manipulable robotic arm. CyberKnife radiosurgery is an effective alternative to conventional surgery or radiation therapy for a range of tumors and some non-neoplastic disorders. This report will describe CyberKnife technology and oncologic applications in neurosurgery and throughout the body.

[1]  Steven D Chang,et al.  Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma. , 2002, International journal of radiation oncology, biology, physics.

[2]  Michiyasu Suzuki,et al.  CyberKnife radiosurgery for vestibular schwannoma. , 2004, Minimally invasive neurosurgery : MIN.

[3]  M. Bussière,et al.  Stereotactic proton radiosurgery. , 1999, Neurosurgery clinics of North America.

[4]  K. Winston,et al.  Radiosurgery for arteriovenous malformations of the brain using a standard linear accelerator: rationale and technique. , 1988, International journal of radiation oncology, biology, physics.

[5]  C Munari,et al.  Stereotactic radiosurgery with the linear accelerator: treatment of arteriovenous malformations. , 1989, Neurosurgery.

[6]  K. Winston,et al.  A system for stereotactic radiosurgery with a linear accelerator , 1988 .

[7]  J. Adler,et al.  An Anthropomorphic Phantom Study of the Accuracy of CyberKnife Spinal Radiosurgery , 2004, Neurosurgery.

[8]  Steven D Chang,et al.  Image-guided Hypo-fractionated Stereotactic Radiosurgery to Spinal Lesions , 2001, Neurosurgery.

[9]  Stereotactic radiosurgery utilizing a linear accelerator. , 1985, Applied neurophysiology.

[10]  K. Forster,et al.  Fractionated stereotactic radiosurgery and preservation of hearing in patients with vestibular schwannoma: a preliminary report. , 1999, Neurosurgery.

[11]  S. Fan,et al.  Nonresectional therapies for hepatocellular carcinoma. , 1997, American journal of surgery.

[12]  J. Adler,et al.  CyberKnife Radiotherapy for Localized Prostate Cancer: Rationale and Technical Feasibility , 2003, Technology in cancer research & treatment.

[13]  L. Leksell,et al.  Sterotaxic radiosurgery in trigeminal neuralgia. , 1971, Acta chirurgica Scandinavica.

[14]  William C Welch,et al.  Combination kyphoplasty and spinal radiosurgery: a new treatment paradigm for pathological fractures. , 2005, Journal of neurosurgery. Spine.

[15]  K. Winston,et al.  Linear accelerator as a neurosurgical tool for stereotactic radiosurgery. , 1988, Neurosurgery.

[16]  Steven D Chang,et al.  Efficacy and safety of stereotactic radiosurgery for glomus jugulare tumors. , 2004, Neurosurgical focus.

[17]  R L Siddon,et al.  Stereotactic radiosurgery for intracranial arteriovenous malformations using a standard linear accelerator. , 1989, International journal of radiation oncology, biology, physics.

[18]  S. Kalnicki,et al.  CyberKnife Frameless Stereotactic Radiosurgery for Spinal Lesions: Clinical Experience in 125 Cases , 2004, Neurosurgery.

[19]  D. Kondziolka,et al.  Gamma knife radiosurgery for acoustic tumors: multivariate analysis of four year results. , 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[20]  K. Frankel,et al.  Charged-particle stereotactic radiosurgery , 1985 .

[21]  L D Lunsford,et al.  Stereotactic radiosurgery of the brain using the first United States 201 cobalt-60 source gamma knife. , 1989, Neurosurgery.

[22]  A. Ertl,et al.  Gamma Knife Radiosurgery of Acoustic Neurinomas , 2001, Acta Neurochirurgica.

[23]  D. Kondziolka,et al.  Long-term outcomes after radiosurgery for acoustic neuromas. , 1998, The New England journal of medicine.

[24]  D. Kondziolka,et al.  Radiosurgery as an alternative to microsurgery of acoustic tumors. , 1992, Clinical neurosurgery.

[25]  Jean-Claude Latombe,et al.  Image-Guided Robotic Radiosurgery , 1994, Modelling and Planning for Sensor Based Intelligent Robot Systems.

[26]  Jennifer Brainard,et al.  Initial evaluation of Cyberknife technology for extracorporeal renal tissue ablation. , 2003, Urology.

[27]  J. Cassady,et al.  Clinical radiation nephropathy. , 1995, International journal of radiation oncology, biology, physics.

[28]  Steven D Chang,et al.  Image Guided Stereotactic Radiosurgery for Lesions in Proximity to the Anterior Visual Pathways: A Preliminary Report , 2002, Technology in cancer research & treatment.

[29]  Sonja Dieterich,et al.  CyberKnife stereotactic radiosurgical treatment of spinal tumors for pain control and quality of life. , 2005, Journal of neurosurgery. Spine.

[30]  Albert C Koong,et al.  Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. , 2004, International journal of radiation oncology, biology, physics.

[31]  Steven D Chang,et al.  Preliminary Visual Field Preservation after Staged CyberKnife Radiosurgery for Perioptic Lesions , 2004, Neurosurgery.

[32]  C. Cox,et al.  Renal adenocarcinoma: 28-year review, with emphasis on rationale and feasibility of preoperative radiotherapy. , 1970, The Journal of urology.

[33]  Steven D Chang,et al.  Multisession CyberKnife Radiosurgery for Intramedullary Spinal Cord Arteriovenous Malformations , 2006, Neurosurgery.

[34]  O. Pastyr,et al.  Stereotactic percutaneous single dose irradiation of brain metastases with a linear accelerator. , 1987, International journal of radiation oncology, biology, physics.

[35]  Maximilian Reiser,et al.  Technical description, phantom accuracy, and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery. , 2006, Journal of neurosurgery. Spine.

[36]  O. Betti,et al.  Hyperselective Encephalic Irradiation with Linear Accelerator , 1984 .

[37]  Quynh-Thu Le,et al.  Results of a Phase I Dose-Escalation Study Using Single-Fraction Stereotactic Radiotherapy for Lung Tumors , 2006, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[38]  S. Kalnicki,et al.  Evaluation of CyberKnife Frameless Real-Time Image-Guided Stereotactic Radiosurgery for Spinal Lesions , 2004, Stereotactic and Functional Neurosurgery.

[39]  R. Coffey,et al.  Stereotactic radiosurgery using the gamma knife for acoustic neuromas. , 1995, International journal of radiation oncology, biology, physics.

[40]  M Pla,et al.  Dynamic stereotactic radiosurgery. , 1988, International journal of radiation oncology, biology, physics.

[41]  L. Lunsford,et al.  Stereotactic radiosurgery using the 201 cobalt-60 source gamma knife. , 1990, Neurosurgery clinics of North America.

[42]  A. Hamilton,et al.  A prototype device for linear accelerator-based extracranial radiosurgery. , 1995, Acta neurochirurgica. Supplement.

[43]  J R Adler,et al.  Clinical experience with image-guided robotic radiosurgery (the Cyberknife) in the treatment of brain and spinal cord tumors. , 1998, Neurologia medico-chirurgica.

[44]  D. Kondziolka,et al.  Radiosurgery of acoustic neurinomas , 1991, Cancer.

[45]  F J Bova,et al.  The University of Florida radiosurgery system. , 1989, Surgical neurology.

[46]  L. Leksell,et al.  Cerebral radiosurgery. I. Gammathalanotomy in two cases of intractable pain. , 1968, Acta chirurgica Scandinavica.

[47]  E. Tanaka,et al.  CyberKnife stereotactic irradiation for metastatic brain tumors. , 2002, Radiation medicine.

[48]  D. Forster,et al.  Radiosurgery: a minimally interventional alternative to microsurgery in the management of acoustic neuroma. , 1996, British journal of neurosurgery.

[49]  K. Forster,et al.  Image-guided radiosurgery for the spine and pancreas. , 2000, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[50]  A A Patil.  Radiosurgery with the linear accelerator. , 1989 .

[51]  Quynh-Thu Le,et al.  Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial. , 2003, The Annals of thoracic surgery.

[52]  W Schlegel,et al.  Cerebral radiation surgery using moving field irradiation at a linear accelerator facility. , 1985, International journal of radiation oncology, biology, physics.

[53]  G K Svensson,et al.  Dynamic field shaping for stereotactic radiosurgery: a modeling study. , 1993, International journal of radiation oncology, biology, physics.

[54]  D. Kondziolka,et al.  Radiosurgery: Current Techniques , 2003 .

[55]  T. Kirn.  Proton radiotherapy: some perspectives. , 1988, JAMA.

[56]  M J Murphy,et al.  The Cyberknife: a frameless robotic system for radiosurgery. , 1997, Stereotactic and functional neurosurgery.

[57]  D. Kondziolka,et al.  Results of acoustic neuroma radiosurgery: an analysis of 5 years' experience using current methods. , 2001, Journal of neurosurgery.

[58]  H. Fodstad,et al.  Treatment of chronic obsessive compulsive states with stereotactic anterior capsulotomy or cingulotomy , 2005, Acta Neurochirurgica.

[59]  M. Niwa,et al.  [A new strategy for the treatment of jugular foramen tumors using radiosurgery]. , 1995, No shinkei geka. Neurological surgery.

[60]  Quynh-Thu Le,et al.  Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer. , 2005, International journal of radiation oncology, biology, physics.

[61]  L. Lunsford,et al.  Stereotactic radiosurgery in the treatment of patients with acoustic tumors. , 1992, Otolaryngologic clinics of North America.

[62]  L D Lunsford,et al.  Stereotactic radiosurgery for acoustic neuromas. , 1990, Archives of otolaryngology--head & neck surgery.

[63]  Steven D Chang,et al.  CyberKnife Radiosurgery for Benign Intradural Extramedullary Spinal Tumors , 2006, Neurosurgery.

[64]  Steven D Chang,et al.  Staged Stereotactic Irradiation for Acoustic Neuroma , 2005, Neurosurgery.

[65]  Steven D Chang,et al.  Robotics and Radiosurgery – The Cyberknife , 2002, Stereotactic and Functional Neurosurgery.

[66]  E. Riches.  The place of radiotherapy in the management of parenchymal carcinoma of the kidney. , 1966, Transactions of the American Association of Genito-Urinary Surgeons.