Diagnostic dilemmas in helminthology: what tools to use and when?

Available data regarding the distribution, prevalence and severity of various diseases are based on the performance and operational characteristics of the diagnostic techniques applied; this is a fact that is particularly apparent in the study of helminth infections. An important lesson learnt from the efforts to rein in dracunculiasis, lymphatic filariasis and schistosomiasis is that the diagnostic approach needs to be changed as further progress is made towards control and ultimate elimination of the disease. This insight prompted the opinion piece presented here, which highlights diagnostic dilemmas in helminthology related to the stage of control achieved and sets out some research needs.

[1]  R. Ridley.  Diagnostics take centre stage , 2006, Nature Reviews Microbiology.

[2]  D. Rollinson,et al.  Implementation of human schistosomiasis control: Challenges and prospects. , 2006, Advances in parasitology.

[3]  B. Vennervald,et al.  Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine , 2000, Tropical medicine & international health : TM & IH.

[4]  L. Savioli,et al.  Reconsidering the underestimated burden caused by neglected tropical diseases. , 2006, Trends in parasitology.

[5]  J. Dalton,et al.  Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica , 2006, Parasitology.

[6]  Wensen Liu,et al.  Paragonimiasis: an important food-borne zoonosis in China. , 2008, Trends in parasitology.

[7]  J. Utzinger,et al.  FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans. , 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[8]  Marcel Tanner,et al.  Questionnaires for rapid screening of schistosomiasis in sub-Saharan Africa. , 2002, Bulletin of the World Health Organization.

[9]  C. Antunes,et al.  Imaging techniques in the evaluation of morbidity in schistosomiasis mansoni. , 2008, Acta tropica.

[10]  Peter J Hotez,et al.  Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm , 2006, The Lancet.

[11]  Jürg Utzinger,et al.  A blueprint for success: integration of neglected tropical disease control programmes. , 2006, Trends in parasitology.

[12]  L. Chitsulo,et al.  The global epidemiological situation of schistosomiasis and new approaches to control and research. , 2002, Acta tropica.

[13]  N. Bergquist,et al.  Post-transmission schistosomiasis: a new agenda. , 2000, Acta tropica.

[14]  A. Crampin,et al.  Time delays between patient and laboratory selectively affect accuracy of helminth diagnosis. , 2007, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[15]  J. Utzinger,et al.  Extensive multiparasitism in a village of Yunnan province, People's Republic of China, revealed by a suite of diagnostic methods. , 2008, The American journal of tropical medicine and hygiene.

[16]  J. Chai,et al.  Prevalence of intestinal parasite infections on a national scale among primary schoolchildren in Laos , 2003, Parasitology Research.

[17]  Rosanna W. Peeling,et al.  Evaluation of diagnostic tests for infectious diseases: general principles , 2006, Nature Reviews Microbiology.

[18]  T. Laha,et al.  Improvement of PCR for Detection of Opisthorchis viverrini DNA in Human Stool Samples , 2007, Journal of Clinical Microbiology.

[19]  Mamta K. Jain,et al.  Biliary parasites: Diagnostic and therapeutic strategies , 2008, Current treatment options in gastroenterology.

[20]  Soil-transmitted Helminthiasis.  Prevention and control of schistosomiasis and soil-transmitted helminthiasis : report of a WHO expert committee , 2002 .

[21]  E. Ruiz-Tiben,et al.  Dracunculiasis (Guinea worm disease) eradication. , 2006, Advances in parasitology.

[22]  P. J. Hooper,et al.  Projected benefits from integrating NTD programs in sub-Saharan Africa. , 2006, Trends in parasitology.

[23]  Yin-chang Zhu.  Immunodiagnosis and its role in schistosomiasis control in China: a review. , 2005, Acta tropica.

[24]  Marcel Tanner,et al.  Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. , 2006, The Lancet. Infectious diseases.

[25]  V. Schall,et al.  A combined strategy to improve the control of Schistosoma mansoni in areas of low prevalence in Brazil. , 2008, The American journal of tropical medicine and hygiene.

[26]  A. Onapa,et al.  Neglected tropical diseases in Uganda: the prospect and challenge of integrated control , 2007, Trends in parasitology.

[27]  A. Fenwick.  New initiatives against Africa's worms. , 2006, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[28]  B. Sripa.  Concerted Action Is Needed to Tackle Liver Fluke Infections in Asia , 2008, PLoS neglected tropical diseases.

[29]  Peter J Hotez,et al.  Helminth infections: the great neglected tropical diseases. , 2008, The Journal of clinical investigation.

[30]  J. Utzinger,et al.  Diagnosis of Soil-Transmitted Helminths in the Era of Preventive Chemotherapy: Effect of Multiple Stool Sampling and Use of Different Diagnostic Techniques , 2008, PLoS neglected tropical diseases.

[31]  Eric A Ottesen,et al.  Lymphatic filariasis: Treatment, control and elimination. , 2006, Advances in parasitology.

[32]  J. Utzinger,et al.  A single FLOTAC is more sensitive than triplicate Kato-Katz for the diagnosis of low-intensity soil-transmitted helminth infections. , 2009, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[33]  P Vounatsou,et al.  The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire , 2003, Parasitology.

[34]  A. Dalsgaard,et al.  Fishborne Zoonotic Intestinal Trematodes, Vietnam , 2007, Emerging infectious diseases.

[35]  A. Thomas,et al.  A novel and sensitive method to monitor helminth infections by faecal sampling. , 2002, Acta tropica.

[36]  Robin B Gasser,et al.  Clonorchiasis: a key foodborne zoonosis in China. , 2005, The Lancet. Infectious diseases.

[37]  J. Utzinger,et al.  Emerging Foodborne Trematodiasis , 2005, Emerging infectious diseases.

[38]  Jürg Utzinger,et al.  Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis , 2008, Current opinion in infectious diseases.

[39]  P. Jordan,et al.  From katayama to the Dakhla Oasis: the beginning of epidemiology and control of bilharzia. , 2000, Acta tropica.

[40]  Rosanna W Peeling,et al.  A guide for diagnostic evaluations , 2006, Nature Reviews Microbiology.

[41]  J. Utzinger,et al.  Occurrence of Strongyloides stercoralis in Yunnan Province, China, and Comparison of Diagnostic Methods , 2007, PLoS neglected tropical diseases.

[42]  N. Kabatereine,et al.  Assessment of Schistosoma mansoni induced intestinal inflammation by means of eosinophil cationic protein, eosinophil protein X and myeloperoxidase before and after treatment with praziquantel. , 2008, Acta tropica.

[43]  Jürg Utzinger,et al.  Integrated disease mapping in a polyparasitic world. , 2007, Geospatial health.

[44]  N Katz,et al.  A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. , 1972, Revista do Instituto de Medicina Tropical de Sao Paulo.

[45]  H Guyatt,et al.  Different approaches to modelling the cost-effectiveness of schistosomiasis control. , 1998, Memorias do Instituto Oswaldo Cruz.

[46]  P. Chiodini,et al.  Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies? , 2004, Trends in parasitology.

[47]  S. D. de Vlas,et al.  Underestimation of Schistosoma mansoni prevalences. , 1992, Parasitology today.

[48]  V. Nguyen,et al.  Prevalence, intensity and risk factors for clonorchiasis and possible use of questionnaires to detect individuals at risk in northern Vietnam. , 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[49]  R. Piarroux,et al.  Current trends in tissue-affecting helminths. , 2008, Parasite.

[50]  J. Aagaard-Hansen,et al.  Local perceptions and practices in regard to opisthorchiasis in two villages in Lao PDR. , 2008, The Southeast Asian journal of tropical medicine and public health.

[51]  E. Sadun.  Studies on Opisthorchis viverrini in Thailand. , 1955, American journal of hygiene.