Evidence for a noradrenergic innervation to α1A‐adrenoceptors in rat kidney

1 Experiments were undertaken to characterize the α1‐adrenoceptor subtype mediating vasoconstrictor responses to periarterial noradrenergic nerve stimulation (PNS) in the isolated perfused kidney of the rat. 2 Vasoconstrictor responses to nerve stimulation were inhibited by prazosin (10 nm), 5‐methyl‐urapidil (30 nm), and nitrendipine (1 μm) but were resistant to inhibition by chloroethylclonidine (100 μm). 3 5‐Methyl‐urapidil (30 nm), chloroethylclonidine (100 μm) and nitrendipine (1 μm) did not inhibit the neuronal release of tritium from nerves loaded with [3H]‐noradrenaline. 4 The results suggest that renovascular α1A‐adrenoceptors receive a noradrenergic innervation and that the innervated receptors are coupled to dihydropyridine‐sensitive calcium channels.

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