Oxysterols and mesenchymal stem cell biology.

[1]  S. Bydlowski,et al.  Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death , 2017, The Journal of Steroid Biochemistry and Molecular Biology.

[2]  Maurizio Memo,et al.  Clinical potentials of human pluripotent stem cells , 2017, Cell Biology and Toxicology.

[3]  S. Glynn,et al.  Mesenchymal stem cells: key players in cancer progression , 2017, Molecular Cancer.

[4]  M. K. Hadden,et al.  A molecular dynamics approach to identify an oxysterol-based hedgehog pathway inhibitor. , 2017, Biochimica et biophysica acta. General subjects.

[5]  V. Lefebvre,et al.  Transcriptional control of chondrocyte specification and differentiation. , 2017, Seminars in cell & developmental biology.

[6]  C. Logie,et al.  Cellular reprogramming for clinical cartilage repair , 2017, Cell Biology and Toxicology.

[7]  J. McLachlan,et al.  The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review , 2017, Front. Endocrinol..

[8]  Kevin E. Riley,et al.  Ligands of Therapeutic Utility for the Liver X Receptors , 2017, Molecules.

[9]  M. Valenti,et al.  Osteogenic Differentiation in Healthy and Pathological Conditions , 2016, International journal of molecular sciences.

[10]  S. Dong,et al.  The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation , 2016, Stem cells international.

[11]  NarcisiRoberto,et al.  Differential Effects of Small Molecule WNT Agonists on the Multilineage Differentiation Capacity of Human Mesenchymal Stem Cells. , 2016 .

[12]  L. Iuliano,et al.  Free Radical-derived Oxysterols: Novel Adipokines Modulating Adipogenic Differentiation of Adipose Precursor Cells. , 2016, The Journal of clinical endocrinology and metabolism.

[13]  G. Muccioli,et al.  Oxysterols: From cholesterol metabolites to key mediators. , 2016, Progress in lipid research.

[14]  L. Fuentes-Mera,et al.  Mesenchymal Stem Cells Subpopulations: Application for Orthopedic Regenerative Medicine , 2016, Stem cells international.

[15]  I. Vattulainen,et al.  Cholesterol oxidation products and their biological importance. , 2016, Chemistry and physics of lipids.

[16]  G. Duda,et al.  Treatment with recombinant human bone morphogenetic protein 7 leads to a transient induction of neutralizing autoantibodies in a subset of patients , 2016, BBA clinical.

[17]  S. Midha,et al.  Osteogenic signaling on silk-based matrices. , 2016, Biomaterials.

[18]  D. Agrawal,et al.  Key transcription factors in the differentiation of mesenchymal stem cells. , 2016, Differentiation; research in biological diversity.

[19]  C. Shuai,et al.  MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review) , 2016, Molecular medicine reports.

[20]  T. Einhorn,et al.  Bone healing in 2016. , 2016, Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases.

[21]  M. K. Hadden,et al.  Synthesis and Evaluation of Osteogenic Oxysterols as Hedgehog Pathway Activators , 2016, ChemMedChem.

[22]  T. Gorojankina Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction , 2016, Cellular and Molecular Life Sciences.

[23]  I. Gelissen,et al.  Oxysterols: Old Tale, New Twists. , 2016, Annual review of pharmacology and toxicology.

[24]  A. Regassa,et al.  Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules , 2016, International journal of molecular sciences.

[25]  Z. Ge,et al.  Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives. , 2015, European cells & materials.

[26]  M. Heiland,et al.  Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro. , 2015, In vivo.

[27]  I. Kwon,et al.  Mitochondrial function contributes to oxysterol-induced osteogenic differentiation in mouse embryonic stem cells. , 2015, Biochimica et biophysica acta.

[28]  A. Lassar,et al.  A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation , 2015, Development.

[29]  S. Bydlowski,et al.  ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line. , 2015, Biochemical and biophysical research communications.

[30]  A. Regassa,et al.  Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol , 2015, BMC Genomics.

[31]  P. Zuk,et al.  In Vitro Osteoinductive Effects of Hydroxycholesterol on Human Adipose-Derived Stem Cells Are Mediated through the Hedgehog Signaling Pathway , 2014, Plastic and reconstructive surgery.

[32]  Sigrid Nachtergaele,et al.  A Novel Osteogenic Oxysterol Compound for Therapeutic Development to Promote Bone Growth: Activation of Hedgehog Signaling and Osteogenesis Through Smoothened Binding , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[33]  S. Sozzani,et al.  LXR‐dependent and ‐independent effects of oxysterols on immunity and tumor growth , 2014, European journal of immunology.

[34]  A. Mikos,et al.  Enhancing chondrogenic phenotype for cartilage tissue engineering: monoculture and coculture of articular chondrocytes and mesenchymal stem cells. , 2014, Tissue engineering. Part B, Reviews.

[35]  A. Ferreira,et al.  Short-term effects of 7-ketocholesterol on human adipose tissue mesenchymal stem cells in vitro. , 2014, Biochemical and biophysical research communications.

[36]  S. Krauss,et al.  Metabolites in vertebrate Hedgehog signaling. , 2014, Biochemical and biophysical research communications.

[37]  A. James,et al.  Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation , 2013, Scientifica.

[38]  P. Ingham,et al.  Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling , 2013, eLife.

[39]  J. Handschel,et al.  Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro , 2013, Stem Cell Research & Therapy.

[40]  W. Kim,et al.  Effects of oleic acid and chicken serum on the expression of adipogenic transcription factors and adipogenic differentiation in hen preadipocytes , 2013, Cell biology international.

[41]  Benjamin R. Myers,et al.  Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. , 2013, Developmental cell.

[42]  C. Glass,et al.  Sterols and oxysterols in immune cell function , 2013, Nature Immunology.

[43]  P. Zuk,et al.  In Vitro Study of a Novel Oxysterol for Osteogenic Differentiation on Rabbit Bone Marrow Stromal Cells , 2013, Plastic and reconstructive surgery.

[44]  Yangqing Xu,et al.  Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling , 2013, Nature chemical biology.

[45]  Michael S. Pepper,et al.  Adipocyte and adipogenesis. , 2013, European journal of cell biology.

[46]  エクストレーム,カリン,et al.  Osteogenic differentiation of mesenchymal stem cells , 2013 .

[47]  S. Allahverdian,et al.  Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: Not all roads lead to Rome , 2013, Molecular and Cellular Endocrinology.

[48]  F. Mallein-Gerin,et al.  Increased Adipogenesis in Cultured Embryonic Chondrocytes and in Adult Bone Marrow of Dominant Negative Erg Transgenic Mice , 2012, PloS one.

[49]  S. Bydlowski,et al.  Protective effects of human amniotic fluid stem cells in a model of aorta allograft vasculopathy in rats. , 2012, Transplantation proceedings.

[50]  M. K. Hadden,et al.  Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. , 2012, ACS medicinal chemistry letters.

[51]  Tomas Jakobsson,et al.  Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. , 2012, Trends in pharmacological sciences.

[52]  A. Moron,et al.  Evaluation of Distinct Freezing Methods and Cryoprotectants for Human Amniotic Fluid Stem Cells Cryopreservation , 2012, Journal of biomedicine & biotechnology.

[53]  V. Olkkonen,et al.  Oxysterols and Their Cellular Effectors , 2012, Biomolecules.

[54]  P. Schlesinger,et al.  Oxysterols are allosteric activators of the oncoprotein Smoothened , 2011, Nature chemical biology.

[55]  S. Bydlowski,et al.  The potential use of stem cells derived from human amniotic fluid in renal diseases , 2011, Kidney international supplements.

[56]  F. Parhami,et al.  Novel oxysterols have pro‐osteogenic and anti‐adipogenic effects in vitro and induce spinal fusion in vivo , 2011, Journal of cellular biochemistry.

[57]  R. Sato Sterol metabolism and SREBP activation. , 2010, Archives of biochemistry and biophysics.

[58]  M. Cohen Jr.,et al.  Hedgehog signaling update. , 2010, American journal of medical genetics. Part A.

[59]  Andrew J. Brown,et al.  Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. , 2009, Molecular aspects of medicine.

[60]  S. Kato,et al.  Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies , 2009, Expert opinion on therapeutic targets.

[61]  M. Lazar,et al.  New developments in adipogenesis , 2009, Trends in Endocrinology & Metabolism.

[62]  M. Makishima,et al.  Suppression of beta-catenin signaling by liver X receptor ligands. , 2009, Biochemical pharmacology.

[63]  F. Parhami,et al.  Oxysterol‐induced osteogenic differentiation of marrow stromal cells is regulated by Dkk‐1 inhibitable and PI3‐kinase mediated signaling , 2008, Journal of cellular biochemistry.

[64]  M. Kassem,et al.  Human mesenchymal stem cells: from basic biology to clinical applications , 2008, Gene Therapy.

[65]  F. Parhami,et al.  Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[66]  F. Parhami,et al.  20(S)‐Hydroxycholesterol Inhibits PPARγ Expression and Adipogenic Differentiation of Bone Marrow Stromal Cells Through a Hedgehog‐Dependent Mechanism , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[67]  F. Parhami,et al.  Oxysterol‐induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC‐ and PKA‐dependent pathway , 2007, Journal of cellular biochemistry.

[68]  S. Nelson,et al.  Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells* , 2007, Journal of Biological Chemistry.

[69]  T. Willson,et al.  Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. , 2007, Molecular cell.

[70]  C. Tabin,et al.  BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing , 2006, Nature Genetics.

[71]  L. Lin,et al.  Runx2 Overexpression Enhances Osteoblastic Differentiation and Mineralization in Adipose - Derived Stem Cells in vitro and in vivo , 2006, Calcified Tissue International.

[72]  Lindolfo da Silva Meirelles,et al.  Mesenchymal stem cells reside in virtually all post-natal organs and tissues , 2006, Journal of Cell Science.

[73]  M. Scott,et al.  Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[74]  H. Ryoo,et al.  Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. , 2006, Gene.

[75]  Xin Zhang,et al.  Laboratory Investigations Runx2 Overexpression Enhances Osteoblastic Differentiation and Mineralization in Adipose - Derived Stem Cells in vitro and in vivo , 2006 .

[76]  D. Prockop,et al.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. , 2006, Cytotherapy.

[77]  Y. Shih,et al.  Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. , 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[78]  M. Fishbein,et al.  Role for Sterol Regulatory Element-Binding Protein in Activation of Endothelial Cells by Phospholipid Oxidation Products , 2004, Circulation research.

[79]  J. Breslow,et al.  Intracellular Cholesterol Transport , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[80]  D. Shouhed,et al.  Oxysterols Regulate Differentiation of Mesenchymal Stem Cells: Pro‐Bone and Anti‐Fat , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[81]  Kozo Nakamura,et al.  PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. , 2004, The Journal of clinical investigation.

[82]  R. Morrison,et al.  Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. , 2003, The Biochemical journal.

[83]  W. Hozack,et al.  Transforming Growth Factor-β-mediated Chondrogenesis of Human Mesenchymal Progenitor Cells Involves N-cadherin and Mitogen-activated Protein Kinase and Wnt Signaling Cross-talk* , 2003, Journal of Biological Chemistry.

[84]  Marie-Christine Chaboissier,et al.  The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. , 2002, Genes & development.

[85]  D. Ramji,et al.  CCAAT/enhancer-binding proteins: structure, function and regulation. , 2002, The Biochemical journal.

[86]  Tomoki Aoyama,et al.  Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. , 2002, Biochemical and biophysical research communications.

[87]  Jay R Lieberman,et al.  The role of growth factors in the repair of bone. Biology and clinical applications. , 2002, The Journal of bone and joint surgery. American volume.

[88]  K. Seuwen,et al.  Stem cell characteristics of human trabecular bone-derived cells. , 2002, Bone.

[89]  B. Spiegelman,et al.  C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. , 2002, Genes & development.

[90]  D. Mangelsdorf,et al.  Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. , 2002, The Journal of investigative dermatology.

[91]  P. Reaven,et al.  Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. , 2002, Journal of lipid research.

[92]  A. Lopes,et al.  Differential effects of enzymatic treatments on the storage and secretion of von Willebrand factor by human endothelial cells. , 2001, Thrombosis research.

[93]  M. Jaye,et al.  PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. , 2000, Nature medicine.

[94]  D Tabor,et al.  Regulation of gene expression by SREBP and SCAP. , 2000, Biochimica et biophysica acta.

[95]  D. Russell,et al.  Oxysterol biosynthetic enzymes. , 2000, Biochimica et biophysica acta.

[96]  J. Gimble,et al.  Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? , 2000, Bone.

[97]  P. Robey Stem cells near the century mark. , 2000, The Journal of clinical investigation.

[98]  D. Mangelsdorf,et al.  Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. , 2000, Journal of Investigative Dermatology.

[99]  F. Gage,et al.  Mammalian neural stem cells. , 2000, Science.

[100]  N. Kulagina,et al.  Fibroblast precursors in normal and irradiated mouse hematopoietic organs. , 1976, Experimental hematology.