Further observations on the effects of abruptly increased osmotic pressure of plasma on cerebrosinal-fluid pressure in man.

I N A previous publication, 7 it was assumed tha t hypertonic solutions introduced into the venous system produced cerebral decompression by the creation of an osmotic increment in the blood to the brain. The preliminary data seemed to indicate a direct relationship between the degree of fall in cerebrospinal-fluid pressure and the magnitude of this increment. The present investigation was under taken to substantiate this hypothesis and to explore further the effects of such "osmotic agents."