Novel mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes for peptide and protein delivery

Objectives The purpose of this study was the preparation and characterisation of mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes prepared at various pHs and at different molar ratios.

[1]  L. Illum.  Nasal drug delivery--possibilities, problems and solutions. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[2]  V. Dodane,et al.  Effect of chitosan on epithelial permeability and structure. , 1999, International journal of pharmaceutics.

[3]  Schipper,et al.  Nasal mucociliary clearance as a factor in nasal drug delivery. , 1998, Advanced drug delivery reviews.

[4]  Nikolaos A. Peppas,et al.  Pharmaceutical and Medical Aspects of Bioadhesive Systems for Drug Administration , 1988 .

[5]  N. Peppas,et al.  Bioadhesive intraoral release systems: design, testing and analysis. , 1984, Biomaterials.

[6]  Kozo Takayama,et al.  Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[7]  S. Vasilyeva,et al.  Characteristics of Interactions in the Pectin–Chitosan System , 2004 .

[8]  Lisbeth Illum,et al.  Chitosan as a Novel Nasal Delivery System for Peptide Drugs , 1994, Pharmaceutical Research.

[9]  Alain Domard,et al.  Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes. Physico-chemical aspects , 1996 .

[10]  S. S. Davis,et al.  Nasal Absorption of Desmopressin in Rats and Sheep. Effect of a Bioadhesive Microsphere Delivery System , 1994, The Journal of pharmacy and pharmacology.

[11]  Nikolaos A. Peppas,et al.  Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues , 1985 .

[12]  A. Domard,et al.  Interactions between chitosan and glycosaminoglycans (chondroitin sulfate and hyaluronic acid): physicochemical and biological studies. , 2000, Annales pharmaceutiques francaises.

[13]  A. Domard,et al.  Polyelectrolyte Complexes. Interaction of Poly(L-lysine)-Poly(L-glutamic acid) in Dilute Aqueous Solution , 1980 .

[14]  Lisbeth Illum,et al.  Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) , 1994, Pharmaceutical Research.

[15]  Lichen Yin,et al.  Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles. , 2008, International journal of pharmaceutics.

[16]  B. Luppi,et al.  Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[17]  Robert Gurny,et al.  Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[18]  R. Bodmeier,et al.  In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[19]  N. Peppas,et al.  Hydrogels as mucoadhesive and bioadhesive materials: a review. , 1996, Biomaterials.

[20]  B. Luppi,et al.  New environmental sensitive system for colon-specific delivery of peptidic drugs. , 2008, International journal of pharmaceutics.

[21]  N. Larionova,et al.  Fabrication and Characterization of Polyelectrolyte Microparticles with Protein , 2004, Biochemistry (Moscow).

[22]  Clive G. Wilson,et al.  Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scintigraphy. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[23]  P. Welling,et al.  In vivo evaluation of nicotine lyophilised nasal insert in sheep. , 2005, International journal of pharmaceutics.