Immunological mechanisms and therapeutic targets of fatty liver diseases

[1]  Y. Rotman,et al.  Immunological mechanisms and therapeutic targets of fatty liver diseases , 2020, Cellular & Molecular Immunology.

[2]  D. Kleiner,et al.  Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis , 2020, Redox biology.

[3]  S. Hewitt,et al.  4-HNE Immunohistochemistry and Image Analysis for Detection of Lipid Peroxidation in Human Liver Samples Using Vitamin E Treatment in NAFLD as a Proof of Concept , 2020, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[4]  Y. Huang,et al.  Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: The role of oxidative stress. , 2020, Toxicology in vitro : an international journal published in association with BIBRA.

[5]  D. Kleiner,et al.  17‐Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury , 2020, Hepatology.

[6]  J. Trotter,et al.  Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis. , 2020, Gastroenterology.

[7]  M. Lamkanfi,et al.  Therapeutic modulation of inflammasome pathways , 2020, Immunological reviews.

[8]  Brian C. Davis,et al.  A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder , 2020, Hepatology.

[9]  H. Cao,et al.  Lipotoxic Hepatocyte‐Derived Exosomal MicroRNA 192‐5p Activates Macrophages Through Rictor/Akt/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease , 2020 .

[10]  B. Barton,et al.  Design and rationale of a multicenter defeat alcoholic steatohepatitis trial: (DASH) randomized clinical trial to treat alcohol-associated hepatitis. , 2020, Contemporary clinical trials.

[11]  C. Gandhi,et al.  Yes‐Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis , 2020, Hepatology.

[12]  D. Fouts,et al.  Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans , 2020, Gut microbes.

[13]  D. Pellicci,et al.  Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge , 2020, Nature Reviews Immunology.

[14]  R. Kaufman,et al.  IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. , 2020, Gastroenterology.

[15]  B. Gao,et al.  Interleukin-22 acts as a mitochondrial protector , 2020, Theranostics.

[16]  Richard D. Smith,et al.  Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice , 2020, Journal of Molecular Medicine.

[17]  A. Singal,et al.  Granulocyte colony-stimulating factor for alcoholic hepatitis: A systematic review and meta-analysis of randomised controlled trials , 2020, JHEP reports : innovation in hepatology.

[18]  Daniel M. Rotroff,et al.  Diagnostic and Prognostic Significance of Complement in Patients With Alcohol‐Associated Hepatitis , 2020, Hepatology.

[19]  Peixin Yang,et al.  Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1-p38MAPKα-dependent mechanisms. , 2020, JCI insight.

[20]  Ming-Lin Liu,et al.  Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance between cells/tissues , 2020, Theranostics.

[21]  M. Czaja,et al.  Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis. , 2020, Journal of hepatology.

[22]  G. Marcelin,et al.  Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis. , 2020, Immunity.

[23]  E. Yoshida,et al.  Granulocyte colony stimulating factor: A potential therapeutic rescue in severe alcoholic hepatitis and decompensated cirrhosis. , 2020, Annals of Hepatology.

[24]  J. Villadangos,et al.  MR1: a multi-faceted metabolite sensor for T cell activation. , 2020, Current opinion in immunology.

[25]  J. Bajaj,et al.  Microbiome: Emerging Concepts in Patients with Chronic Liver Disease. , 2020, Clinics in liver disease.

[26]  F. Ginhoux,et al.  Deciphering human macrophage development at single-cell resolution , 2020, Nature.

[27]  C. Datz,et al.  Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers , 2020, Hepatology.

[28]  C. McClain,et al.  Inhibition of Sphingosine‐1‐Phosphate‐Induced Th17 Cells Ameliorates Alcohol‐Associated Steatohepatitis in Mice , 2020, Hepatology.

[29]  P. An,et al.  Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis , 2020, Nature Communications.

[30]  P. Mathurin,et al.  Liver transplantation in patients with alcohol-related liver disease: current status and future directions. , 2020, The lancet. Gastroenterology & hepatology.

[31]  W. Jeong,et al.  Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease , 2020, Experimental & Molecular Medicine.

[32]  S. Bollipo,et al.  What's in a name? Renaming ‘NAFLD’ to ‘MAFLD’ , 2020, Liver international : official journal of the International Association for the Study of the Liver.

[33]  G. Gores,et al.  Lytic Cell Death in Metabolic Liver Disease. , 2020, Journal of hepatology.

[34]  S. Dasarathy,et al.  MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcoholic fatty liver disease. , 2020, Journal of hepatology.

[35]  I. Maričić,et al.  Differential activation of unconventional T cells, including iNKT cells, in alcohol-related liver disease. , 2020, Alcoholism, clinical and experimental research.

[36]  V. Wong,et al.  Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials. , 2020, Journal of hepatology.

[37]  Hongliang Li,et al.  Epidemiological Features of NAFLD From 1999 to 2018 in China , 2020, Hepatology.

[38]  R. Bataller,et al.  Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis , 2020, Hepatology.

[39]  O. Cummings,et al.  Vitamin E Improves Transplant‐Free Survival and Hepatic Decompensation Among Patients With Nonalcoholic Steatohepatitis and Advanced Fibrosis , 2020, Hepatology.

[40]  Aaron W. Miller,et al.  Dietary Synbiotic Supplementation Protects Barrier Integrity of Hepatocytes and Liver Sinusoidal Endothelium in a Mouse Model of Chronic-Binge Ethanol Exposure , 2020, Nutrients.

[41]  P. Kubes,et al.  DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. , 2020, Annual review of pathology.

[42]  A. Mócsai,et al.  Neutrophils as emerging therapeutic targets , 2020, Nature Reviews Drug Discovery.

[43]  Masakazu Hori,et al.  Spatially explicit modeling of metapopulation dynamics of broadcast spawners and stabilizing/destabilizing effects of heterogeneity of quality across local habitats. , 2020, Journal of theoretical biology.

[44]  H. Malhi,et al.  Pathogenesis of Nonalcoholic Steatohepatitis: An Overview , 2020, Hepatology communications.

[45]  R. Bataller,et al.  IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis. , 2020, Journal of hepatology.

[46]  Zhou Zhou,et al.  Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis. , 2020, The American journal of pathology.

[47]  Y. Koyama,et al.  IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. , 2019, Journal of hepatology.

[48]  U. Smith,et al.  The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and NAFLD/NASH , 2019, Diabetes.

[49]  J. Chan,et al.  A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis. , 2019, Journal of hepatology.

[50]  R. Bataller,et al.  Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting , 2019, Gut.

[51]  V. Wong,et al.  Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design. , 2019, Contemporary clinical trials.

[52]  J. Chan,et al.  Randomized Placebo-Controlled Trial of Emricasan in Non-alcoholic Steatohepatitis (NASH) Cirrhosis with Severe Portal Hypertension. , 2019, Journal of hepatology.

[53]  Je-Hyun Yoon,et al.  Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury , 2019, Hepatology.

[54]  J. Sung,et al.  Roseburia Spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. , 2019, Cell host & microbe.

[55]  J. Dufour,et al.  Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial. , 2019, Lancet.

[56]  Samar H. Ibrahim,et al.  Integrin β1-enriched Extracellular Vesicles Mediate Monocyte Adhesion and Promote Liver Inflammation in Murine NASH. , 2019, Journal of hepatology.

[57]  M. Rescigno,et al.  Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development , 2019, Journal of hepatology.

[58]  Douglas A. Simonetto,et al.  An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated Hepatitis , 2019, Hepatology.

[59]  Lei Zhao,et al.  Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p. , 2019, Experimental cell research.

[60]  Zhou Zhou,et al.  Interleukin‐22 Ameliorates Neutrophil‐Driven Nonalcoholic Steatohepatitis Through Multiple Targets , 2019, Hepatology.

[61]  D. Brenner,et al.  The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. , 2019, Cell metabolism.

[62]  K. Cusi,et al.  TEMPORARY REMOVAL: Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study. , 2019, Journal of hepatology.

[63]  H. Malhi.  Emerging Role of Extracellular Vesicles in Liver Diseases. , 2019, American journal of physiology. Gastrointestinal and liver physiology.

[64]  B. Neuschwander‐Tetri,et al.  Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial , 2019, The Lancet.

[65]  S. Zang,et al.  Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism. , 2019, Biochemical and biophysical research communications.

[66]  R. Bataller,et al.  Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease , 2019, Nature.

[67]  H. Wang,et al.  HDAC6 Suppresses Let‐7i‐5p to Elicit TSP1/CD47‐Mediated Anti‐Tumorigenesis and Phagocytosis of Hepatocellular Carcinoma , 2019, Hepatology.

[68]  R. Gerstein,et al.  Alcohol-induced adipose tissue macrophage phenotype switching is independent of myeloid toll-like receptor 4 expression. , 2019, American journal of physiology. Cell physiology.

[69]  Hongliang Li,et al.  Unexpected Rapid Increase in the Burden of NAFLD in China From 2008 to 2018: A Systematic Review and Meta‐Analysis , 2019, Hepatology.

[70]  R. Zhou,et al.  DAMP-sensing receptors in sterile inflammation and inflammatory diseases , 2019, Nature Reviews Immunology.

[71]  J. Venter,et al.  Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. , 2019, Cell metabolism.

[72]  Jiandie D. Lin,et al.  Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. , 2019, Molecular cell.

[73]  M. McMullen,et al.  Specifically-sized hyaluronan (35 kDa) prevents ethanol-induced disruption of epithelial tight junctions through a Layilin-dependent mechanism in Caco-2 cells. , 2019, Alcoholism, clinical and experimental research.

[74]  P. Nilsson,et al.  The Role of Complement in Liver Injury, Regeneration, and Transplantation , 2019, Hepatology.

[75]  C. Weston,et al.  Obesity in acute alcoholic hepatitis increases morbidity and mortality , 2019, EBioMedicine.

[76]  J. Wan,et al.  n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review , 2019, Critical reviews in food science and nutrition.

[77]  S. Cook,et al.  Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis. , 2019, Gastroenterology.

[78]  Wei Li,et al.  Wolfberry-Derived Zeaxanthin Dipalmitate Attenuates Ethanol-Induced Hepatic Damage. , 2019, Molecular nutrition & food research.

[79]  Bin Gao,et al.  Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol‐Inducible Cytochrome P450‐2E1–Mediated Oxidative and Nitrative Stress , 2019, Hepatology.

[80]  Megan M. Sheehan,et al.  Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice. , 2019, Alcoholism, clinical and experimental research.

[81]  T. Luedde,et al.  Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis , 2019, Gut.

[82]  M. Jaeger,et al.  Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes , 2019, Molecular Medicine.

[83]  I. Maričić,et al.  Intestinal iNKT cells migrate to liver and contribute to hepatocyte apoptosis during alcoholic liver disease. , 2019, American journal of physiology. Gastrointestinal and liver physiology.

[84]  Jiandie D. Lin,et al.  Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice. , 2019, The Journal of clinical investigation.

[85]  J. Ting,et al.  The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.

[86]  C. Hedrick,et al.  Nonclassical Monocytes in Health and Disease. , 2019, Annual review of immunology.

[87]  M. Ziol,et al.  A 17‐Beta‐Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver Disease , 2019, Hepatology.

[88]  Xinyan Zhao,et al.  The immunoregulatory effects of CD8 T‐cell–derived perforin on diet‐induced nonalcoholic steatohepatitis , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[89]  W. Jeong,et al.  Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis , 2019, Hepatology.

[90]  Zhou Zhou,et al.  Adipose‐Specific Lipin‐1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice , 2019, Hepatology communications.

[91]  E. Speliotes,et al.  17‐Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease , 2019, Hepatology.

[92]  A. Mari,et al.  Neutrophil-to-lymphocyte ratio is independently associated with inflammatory activity and fibrosis grade in nonalcoholic fatty liver disease. , 2019, European journal of gastroenterology & hepatology.

[93]  C. Mantzoros,et al.  Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics. , 2019, Metabolism: clinical and experimental.

[94]  D. Orlicky,et al.  Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages , 2019, Hepatology.

[95]  Yeonhee Cho,et al.  Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol‐Induced Liver Damage, Steatosis, and Inflammation in Mice , 2019, Hepatology.

[96]  E. Dirinck,et al.  The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity , 2019, Front. Immunol..

[97]  Richard G. Lee,et al.  Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice , 2019, Molecular metabolism.

[98]  S. Sarin,et al.  Microbiome as a therapeutic target in alcohol-related liver disease. , 2019, Journal of hepatology.

[99]  V. Shah,et al.  Current trials and novel therapeutic targets for alcoholic hepatitis. , 2019, Journal of hepatology.

[100]  H. Tsukamoto,et al.  Inflammatory pathways in alcoholic steatohepatitis. , 2019, Journal of hepatology.

[101]  P. Kamath,et al.  Alcohol‐Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study , 2019, Hepatology.

[102]  R. Schwabe,et al.  NLR Family Pyrin Domain‐Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice , 2019, Hepatology.

[103]  G. Cresci,et al.  A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice , 2019, Nutrients.

[104]  M. Honda,et al.  Characteristics of Immune Response to Tumor‐Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma , 2018, Hepatology.

[105]  Yongsheng Yu,et al.  STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis , 2018, The Journal of clinical investigation.

[106]  B. Neuschwander‐Tetri,et al.  Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial , 2018, The Lancet.

[107]  Qifu Li,et al.  Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. , 2018, Gastroenterology.

[108]  C. Sirlin,et al.  Acetyl‐CoA Carboxylase Inhibitor GS‐0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis , 2018, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[109]  R. Yang,et al.  DAMPs and sterile inflammation in drug hepatotoxicity , 2018, Hepatology International.

[110]  J. Kwon,et al.  Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice. , 2018, The American journal of pathology.

[111]  R. Loomba,et al.  GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease. , 2018, Gastroenterology.

[112]  K. Kodys,et al.  Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use. , 2018, Journal of hepatology.

[113]  G. Szabo,et al.  Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression , 2018, Journal of Neuroinflammation.

[114]  T. Weir,et al.  The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD , 2018, Nature Communications.

[115]  J. Vince,et al.  Pyroptosis versus necroptosis: similarities, differences, and crosstalk , 2018, Cell Death & Differentiation.

[116]  Austin D. Swafford,et al.  Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis , 2018, The Journal of Immunology.

[117]  X. Ruan,et al.  Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release. , 2018, Cellular immunology.

[118]  J. Niu,et al.  Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids , 2018, Gut.

[119]  A. Tsung,et al.  Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis , 2018, Hepatology.

[120]  Megan M. Sheehan,et al.  Complement Factor D protects mice from ethanol-induced inflammation and liver injury. , 2018, American journal of physiology. Gastrointestinal and liver physiology.

[121]  B. Gao,et al.  Interleukin-22 from bench to bedside: a promising drug for epithelial repair , 2018, Cellular & Molecular Immunology.

[122]  Justine W. Debelius,et al.  The gut–liver axis and the intersection with the microbiome , 2018, Nature Reviews Gastroenterology & Hepatology.

[123]  A. Feldstein,et al.  Triggering and resolution of inflammation in NASH , 2018, Nature Reviews Gastroenterology & Hepatology.

[124]  R. Harris,et al.  Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference , 2018, Alcoholism, clinical and experimental research.

[125]  Richard D. Smith,et al.  Pyroptosis by caspase11/4‐gasdermin‐D pathway in alcoholic hepatitis in mice and patients , 2018, Hepatology.

[126]  K. Kodys,et al.  Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90 , 2018, Hepatology.

[127]  T. Luedde,et al.  Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis , 2018, Hepatology.

[128]  Alexander E. Lopez,et al.  A Protein‐Truncating HSD17B13 Variant and Protection from Chronic Liver Disease , 2018, The New England journal of medicine.

[129]  A. Feldstein,et al.  Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases. , 2018, Liver research.

[130]  F. Tacke.  Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis , 2018, Expert opinion on investigational drugs.

[131]  L. Dara,et al.  The Receptor Interacting Protein Kinases in the Liver , 2018, Seminars in Liver Disease.

[132]  G. Svegliati-Baroni,et al.  Lipotoxicity and the gut-liver axis in NASH pathogenesis. , 2018, Journal of hepatology.

[133]  D. Schuppan,et al.  Determinants of fibrosis progression and regression in NASH. , 2018, Journal of hepatology.

[134]  G. Gores,et al.  Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation , 2018, Gut.

[135]  Natalie J Torok,et al.  Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis , 2018, Cellular and molecular gastroenterology and hepatology.

[136]  Zhanxiang Zhou,et al.  Targeting the gut barrier for the treatment of alcoholic liver disease. , 2017, Liver research.

[137]  R. Bataller,et al.  Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long‐term survival , 2017, Hepatology.

[138]  B. Gao,et al.  MAIT cells: a novel therapeutic target for alcoholic liver disease? , 2017, Gut.

[139]  S. Menini,et al.  Deficiency of the Purinergic Receptor 2X7 Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome , 2017, Oxidative medicine and cellular longevity.

[140]  P. Klenerman,et al.  Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease , 2017, Gut.

[141]  R. Bataller,et al.  Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients. , 2017, Journal of hepatology.

[142]  M. Picard,et al.  Evidence Suggesting Absence of Mitochondrial DNA Methylation , 2017, Front. Genet..

[143]  C. Stehouwer,et al.  Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice , 2017, Gut.

[144]  B. Stockwell,et al.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.

[145]  S. Whittemore,et al.  Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation , 2017, Neuropharmacology.

[146]  R. Flisiak,et al.  Serum Concentrations of Th17-Associated Interleukins and Autoimmune Phenomena are Associated with the Degree of Liver Damage in Alcoholic Liver Disease. , 2017, Journal of gastrointestinal and liver diseases : JGLD.

[147]  G. Cresci,et al.  Prophylactic tributyrin treatment mitigates chronic‐binge ethanol‐induced intestinal barrier and liver injury , 2017, Journal of gastroenterology and hepatology.

[148]  J. Hamdorf,et al.  TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival. , 2017, Clinical science.

[149]  J. Byun,et al.  Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease , 2017, BioMed research international.

[150]  Ruixin Zhu,et al.  Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD , 2017, Gut.

[151]  C. A. de la Motte,et al.  MicroRNA 181b‐3p and its target importin α5 regulate toll‐like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol , 2017, Hepatology.

[152]  H. Tilg,et al.  Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions , 2017, International journal of molecular sciences.

[153]  R. Star,et al.  Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity. , 2017, JCI insight.

[154]  S. Liangpunsakul,et al.  Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance. , 2017, Gene expression.

[155]  S. Koo,et al.  RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis. , 2017, Cell reports.

[156]  Jun Li,et al.  Hepatic mitochondrial DNA/Toll‐like receptor 9/MicroRNA‐223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice , 2017, Hepatology.

[157]  Y. Koyama,et al.  Intestinal fungi contribute to development of alcoholic liver disease , 2017, The Journal of clinical investigation.

[158]  G. Szabo,et al.  Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets , 2017, Nature Reviews Gastroenterology &Hepatology.

[159]  K. S. Kim,et al.  Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice. , 2017, Gastroenterology.

[160]  F. Tacke.  Targeting hepatic macrophages to treat liver diseases. , 2017, Journal of hepatology.

[161]  P. Boor,et al.  Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. , 2017, Journal of hepatology.

[162]  L. Miles,et al.  Hepatic natural killer T‐cell and CD8+ T‐cell signatures in mice with nonalcoholic steatohepatitis , 2017, Hepatology communications.

[163]  Yi-horng Lee,et al.  The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. , 2017, Molecular aspects of medicine.

[164]  Shibu Yooseph,et al.  Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. , 2017, Cell metabolism.

[165]  A. Feldstein,et al.  Inflammasomes in Liver Fibrosis , 2017, Seminars in Liver Disease.

[166]  J. Schaffer,et al.  Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis , 2017, Hepatology.

[167]  K. Schroder,et al.  NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. , 2017, Journal of hepatology.

[168]  W. Chapman,et al.  Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome , 2017, Science Immunology.

[169]  Wenqing Gao,et al.  Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. , 2017, Trends in biochemical sciences.

[170]  D. Ciocan,et al.  Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice. , 2017, Journal of hepatology.

[171]  F. Tacke,et al.  Liver macrophages in tissue homeostasis and disease , 2017, Nature Reviews Immunology.

[172]  F. Vocci,et al.  Avatar-assisted therapy: a proof-of-concept pilot study of a novel technology-based intervention to treat substance use disorders , 2017, The American journal of drug and alcohol abuse.

[173]  C. Lang,et al.  Alcohol, Adipose Tissue and Lipid Dysregulation , 2017, Biomolecules.

[174]  B. Staels,et al.  Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia and NAFLD. , 2017 .

[175]  B. A. de Boer,et al.  Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice. , 2016, Biochimica et biophysica acta.

[176]  F. Anania,et al.  Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol. , 2016, Gastroenterology.

[177]  F. Bäckhed,et al.  Signals from the gut microbiota to distant organs in physiology and disease , 2016, Nature Medicine.

[178]  Yueqiu Gao,et al.  MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47phox–oxidative stress pathway in neutrophils , 2016, Gut.

[179]  L. Gobejishvili,et al.  Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol‐induced steatosis , 2016, The Journal of pathology.

[180]  G. Addolorato,et al.  Treatment of alcohol use disorders in patients with alcoholic liver disease. , 2016, Journal of hepatology.

[181]  R. Serra,et al.  Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers. , 2016, International journal of surgery.

[182]  M. McMullen,et al.  Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice. , 2016, Gene expression.

[183]  H. Van Vlierberghe,et al.  Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice. , 2016, American journal of physiology. Gastrointestinal and liver physiology.

[184]  P. Dawson,et al.  Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives , 2016, Hepatology.

[185]  R. Reimer,et al.  Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation , 2016, PloS one.

[186]  A. Waisman,et al.  Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma. , 2016, Cancer cell.

[187]  Lee A. Vucovich,et al.  Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review. , 2016, Alcoholism, clinical and experimental research.

[188]  M. E. Medof,et al.  Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice. , 2016, Molecular immunology.

[189]  N. LeBrasseur,et al.  CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis , 2016, Scientific Reports.

[190]  J. Hardies,et al.  Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus , 2016, Annals of Internal Medicine.

[191]  Liying Li,et al.  Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury , 2016, Scientific Reports.

[192]  A. Diehl,et al.  Pathogenesis of Nonalcoholic Steatohepatitis. , 2016, Gastroenterology.

[193]  G. Cresci,et al.  Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes. , 2016, Gastroenterology.

[194]  K. Kodys,et al.  The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis. , 2016, Journal of hepatology.

[195]  Hongliang Li,et al.  Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis. , 2016, Journal of hepatology.

[196]  Philippe Lehert,et al.  Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. , 2016, Gastroenterology.

[197]  T. Karlsen,et al.  High‐throughput T‐cell receptor sequencing across chronic liver diseases reveals distinct disease‐associated repertoires , 2016, Hepatology.

[198]  G. Gores,et al.  Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. , 2016, Gastroenterology.

[199]  H. Tilg,et al.  Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease. , 2016, Journal of hepatology.

[200]  G. Gores,et al.  Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. , 2016, Journal of hepatology.

[201]  G. Gores,et al.  Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes , 2016, Hepatology.

[202]  R. Coffman,et al.  Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. , 2016, The Journal of clinical investigation.

[203]  Rachel M. Brown,et al.  Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study , 2016, The Lancet.

[204]  D. Brenner,et al.  Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. , 2016, Cell host & microbe.

[205]  Frank Tacke,et al.  Immunology in the liver — from homeostasis to disease , 2016, Nature Reviews Gastroenterology &Hepatology.

[206]  G. Musso,et al.  Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies , 2016, Nature Reviews Drug Discovery.

[207]  M. Komatsu,et al.  Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury , 2016, Oncotarget.

[208]  H. Hermanns,et al.  Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver , 2016, The Journal of Immunology.

[209]  D. Ciocan,et al.  Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease , 2015, Gut.

[210]  C. Sasakawa,et al.  Molecular mechanisms regulating NLRP3 inflammasome activation , 2015, Cellular and Molecular Immunology.

[211]  K. Kodys,et al.  Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. , 2015, Journal of hepatology.

[212]  H. Tilg,et al.  Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions , 2015, The Journal of Immunology.

[213]  M. Uribe,et al.  The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease , 2015, BioMed research international.

[214]  M. Rizzo,et al.  Nonalcoholic Fatty Liver Disease, Cardiovascular Risk, and Carotid Inflammation , 2015, Angiology.

[215]  K. Kodys,et al.  Metabolic danger signals, uric acid and ATP, mediate inflammatory cross‐talk between hepatocytes and immune cells in alcoholic liver disease , 2015, Journal of leukocyte biology.

[216]  E. Seki,et al.  TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration. , 2015, American journal of physiology. Gastrointestinal and liver physiology.

[217]  K. Kodys,et al.  Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS , 2015, Scientific Reports.

[218]  A. Burt,et al.  Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. , 2015, Journal of hepatology.

[219]  C. Trautwein,et al.  TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. , 2015, Journal of hepatology.

[220]  I. Maričić,et al.  Inhibition of type I natural killer T cells by retinoids or following sulfatide‐mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice , 2015, Hepatology.

[221]  B. Neuschwander‐Tetri,et al.  Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial , 2015, The Lancet.

[222]  G. Cresci,et al.  Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl₄-induced injury. , 2015, Molecular immunology.

[223]  A. Cassard-Doulcier,et al.  Alcohol withdrawal alleviates adipose tissue inflammation in patients with alcoholic liver disease , 2015, Liver international : official journal of the International Association for the Study of the Liver.

[224]  Jing Li,et al.  Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease , 2015, Scientific Reports.

[225]  G. Szabo,et al.  MicroRNAs in Alcoholic Liver Disease , 2015, Seminars in Liver Disease.

[226]  K. Machida,et al.  Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice , 2015, Hepatology.

[227]  Jun Yu,et al.  CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. , 2014, Journal of hepatology.

[228]  Sébastien Matamoros,et al.  Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity , 2014, Proceedings of the National Academy of Sciences.

[229]  Bin Gao,et al.  Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice , 2014, Journal of leukocyte biology.

[230]  A. Bhalla,et al.  Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study , 2014, The American Journal of Gastroenterology.

[231]  Xiuping Liu,et al.  Regulation of the Extrinsic Apoptotic Pathway by MicroRNA-21 in Alcoholic Liver Injury* , 2014, The Journal of Biological Chemistry.

[232]  A. Feldstein,et al.  Adipocyte Cell Death, Fatty Liver Disease and Associated Metabolic Disorders , 2014, Digestive Diseases.

[233]  Yan Wang,et al.  Toll‐like receptor‐4 signalling in the progression of non‐alcoholic fatty liver disease induced by high‐fat and high‐fructose diet in mice , 2014, Clinical and experimental pharmacology & physiology.

[234]  T. Luedde,et al.  A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis , 2014, EMBO molecular medicine.

[235]  A. Wree,et al.  NLRP3 inflammasome activation is required for fibrosis development in NAFLD , 2014, Journal of Molecular Medicine.

[236]  R. Harris,et al.  Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice , 2014, Front. Neurosci..

[237]  A. Tall,et al.  Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. , 2014, Cell metabolism.

[238]  Andmorgan R. Fisher,et al.  Altered profile of human gut microbiome is associated with cirrhosis and its complications. , 2014, Journal of hepatology.

[239]  P. Hylemon,et al.  Bile acids and the gut microbiome , 2014, Current opinion in gastroenterology.

[240]  R. Bataller,et al.  A histologic scoring system for prognosis of patients with alcoholic hepatitis. , 2014, Gastroenterology.

[241]  K. Irvine,et al.  The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease , 2014, Hepatology.

[242]  D. Crowe,et al.  Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice. , 2014, American journal of physiology. Gastrointestinal and liver physiology.

[243]  Ling-gang Wu,et al.  Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis , 2013, Nature Cell Biology.

[244]  T. Tang,et al.  Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death , 2013, PloS one.

[245]  R. Locksley,et al.  Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice , 2013, The Journal of Immunology.

[246]  B. Gao,et al.  Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E‐selectin , 2013, Hepatology.

[247]  R. Schwabe,et al.  Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice , 2013, Hepatology.

[248]  P. Kubes,et al.  Immune surveillance by the liver , 2013, Nature Immunology.

[249]  L. Galluzzi,et al.  Decoding cell death signals in liver inflammation. , 2013, Journal of hepatology.

[250]  F. Jornayvaz,et al.  Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance. , 2013, The Journal of endocrinology.

[251]  Vipin Kumar.  NKT-cell subsets: promoters and protectors in inflammatory liver disease. , 2013, Journal of hepatology.

[252]  A. Rehman,et al.  Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice , 2013, Hepatology.

[253]  M. Hussain,et al.  Alcohol dehydrogenase–specific T‐cell responses are associated with alcohol consumption in patients with alcohol‐related cirrhosis , 2013, Hepatology.

[254]  Gabriel Núñez,et al.  Control of pathogens and pathobionts by the gut microbiota , 2013, Nature Immunology.

[255]  Ajit S. Divakaruni,et al.  Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins , 2013, PloS one.

[256]  Xiuli Liu,et al.  Absence of receptor interacting protein kinase 3 prevents ethanol‐induced liver injury , 2013, Hepatology.

[257]  C. McClain,et al.  Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. , 2013, Alcohol.

[258]  M. Czaja,et al.  Aging promotes the development of diet‐induced murine steatohepatitis but not steatosis , 2013, Hepatology.

[259]  B. Gao,et al.  Mouse model of chronic and binge ethanol feeding (the NIAAA model) , 2013, Nature Protocols.

[260]  Armando Carvalho,et al.  Lymphocyte subsets in alcoholic liver disease. , 2013, World journal of hepatology.

[261]  Peter Vandenabeele,et al.  Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. , 2013, Immunity.

[262]  H. Mao,et al.  Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease , 2013, The Journal of Immunology.

[263]  C. Flask,et al.  Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis , 2013, PloS one.

[264]  Lixin Zhu,et al.  Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH , 2013, Hepatology.

[265]  K. Kodys,et al.  Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug‐induced, and inflammatory liver diseases , 2012, Hepatology.

[266]  Virginia Nguyen,et al.  Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production* , 2012, The Journal of Biological Chemistry.

[267]  K. Kodys,et al.  IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. , 2012, The Journal of clinical investigation.

[268]  B. Neuschwander‐Tetri,et al.  Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: A pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow‐up study , 2012, Hepatology.

[269]  S. Balk,et al.  Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. , 2012, Immunity.

[270]  Defeng Wu,et al.  Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. , 2012, Free radical biology & medicine.

[271]  Barbara Gross,et al.  Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease , 2012, Journal of Lipid Research.

[272]  H. Kirikoshi,et al.  Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. , 2012, Cell metabolism.

[273]  C. McClain,et al.  Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[274]  E. Crouser,et al.  Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA , 2012, Journal of Immunology.

[275]  A. Feldstein,et al.  Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation. , 2012, Alcoholism, clinical and experimental research.

[276]  J. Olefsky,et al.  Neutrophils mediate insulin resistance in high fat diet fed mice via secreted elastase , 2012, Nature Medicine.

[277]  A. Sanyal,et al.  Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. , 2012, Cell metabolism.

[278]  Z. Halpern,et al.  Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. , 2012, Journal of hepatology.

[279]  Vrajesh V. Parekh,et al.  Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice , 2012, Proceedings of the National Academy of Sciences.

[280]  M. Nakamuta,et al.  Nutrition and Nonalcoholic Fatty Liver Disease: The Significance of Cholesterol , 2012, International journal of hepatology.

[281]  Hartmut Jaeschke,et al.  The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. , 2012, The Journal of clinical investigation.

[282]  S. Kersten,et al.  Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity* , 2012, The Journal of Biological Chemistry.

[283]  A. Feldstein,et al.  Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[284]  D. Jacobsen,et al.  Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. , 2012, Alcoholism, clinical and experimental research.

[285]  A. Feldstein,et al.  Caspase 1-mediated regulation of fibrogenesis in diet-induced steatohepatitis , 2011, Laboratory Investigation.

[286]  C. McClain,et al.  Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. , 2011, The American journal of pathology.

[287]  R. Bataller,et al.  Alcoholic liver disease: pathogenesis and new therapeutic targets. , 2011, Gastroenterology.

[288]  M. Gillum,et al.  Impact of CD1d Deficiency on Metabolism , 2011, PloS one.

[289]  Yan Zeng,et al.  Ethanol impairs differentiation of human adipocyte stromal cells in culture. , 2011, Alcoholism, clinical and experimental research.

[290]  A. Feldstein,et al.  Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice* , 2011, The Journal of Biological Chemistry.

[291]  T. Luedde,et al.  Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury , 2011, Gut.

[292]  M. Martínez-González,et al.  Type of alcoholic beverage and incidence of overweight/obesity in a Mediterranean cohort: the SUN project. , 2011, Nutrition.

[293]  X. Yang,et al.  Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity , 2011, PloS one.

[294]  F. Safavi,et al.  The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF , 2011, Nature Immunology.

[295]  C. Morita,et al.  Regulation and function of IL-17A- and IL-22-producing γδ T cells , 2011, Cellular and Molecular Life Sciences.

[296]  Manolito Torralba,et al.  Enteric dysbiosis associated with a mouse model of alcoholic liver disease , 2011, Hepatology.

[297]  K. Kodys,et al.  Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease* , 2010, The Journal of Biological Chemistry.

[298]  J. O'grady,et al.  Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data , 2010, Gut.

[299]  T. Liang,et al.  The association of genetic variability in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease , 2010, Hepatology.

[300]  A. Stavitsky,et al.  Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. , 2010, Gastroenterology.

[301]  D. Brenner,et al.  Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. , 2010, Gastroenterology.

[302]  I. Dagher,et al.  Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease. , 2010, Journal of hepatology.

[303]  R. Rippe,et al.  Kupffer cell and interleukin‐12–dependent loss of natural killer T cells in hepatosteatosis , 2010, Hepatology.

[304]  W. Junger,et al.  Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury , 2009, Nature.

[305]  J. Dubé,et al.  Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance , 2009, Diabetes.

[306]  D. Bar-Sagi,et al.  In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. , 2009, The Journal of clinical investigation.

[307]  L. J. Hardies,et al.  Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis , 2009, Hepatology.

[308]  T. Kadowaki,et al.  CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity , 2009, Nature Medicine.

[309]  P. Mandrekar,et al.  Signalling pathways in alcohol-induced liver inflammation. , 2009, Journal of hepatology.

[310]  D. A. Gomes,et al.  Inflammasome-mediated regulation of hepatic stellate cells. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[311]  D. Andersen,et al.  Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides. , 2009, The Journal of clinical endocrinology and metabolism.

[312]  F. Sutterwala,et al.  Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. , 2009, The Journal of clinical investigation.

[313]  A. Dolganiuc,et al.  The critical role of toll‐like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88 , 2008, Hepatology.

[314]  Alexander Pertsemlidis,et al.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease , 2008, Nature Genetics.

[315]  D. A. Gomes,et al.  Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll‐like receptor 9 , 2007, Hepatology.

[316]  R. Ravi,et al.  A high‐fat diet and regulatory T cells influence susceptibility to endotoxin‐induced liver injury , 2007, Hepatology.

[317]  S. Previs,et al.  Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. , 2007, Alcoholism, clinical and experimental research.

[318]  Shelly C. Lu,et al.  Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. , 2007, The American journal of clinical nutrition.

[319]  J. Reubi,et al.  GLP-1 Receptor Expression in Human Tumors and Human Normal Tissues: Potential for In Vivo Targeting , 2007, Journal of Nuclear Medicine.

[320]  J. Bernhagen,et al.  MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment , 2007, Nature Medicine.

[321]  L. Audoly,et al.  Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE , 2007, Nature Immunology.

[322]  A. Stavitsky,et al.  Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. , 2007, Gastroenterology.

[323]  S. Meri,et al.  Complement C3 contributes to ethanol‐induced liver steatosis in mice , 2006, Annals of medicine.

[324]  N. Chen,et al.  First-in-class pan caspase inhibitor developed for the treatment of liver disease. , 2005, Journal of medicinal chemistry.

[325]  T. Hibi,et al.  Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice , 2005, Gut.

[326]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[327]  J. Lemasters.  Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. , 2005, Rejuvenation research.

[328]  E. Holme,et al.  Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses , 2004, Journal of leukocyte biology.

[329]  Sander M Houten,et al.  Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. , 2004, The Journal of clinical investigation.

[330]  G. Gores,et al.  Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression , 2003, Hepatology.

[331]  Yu Wang,et al.  The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. , 2003, The Journal of clinical investigation.

[332]  C. McClain,et al.  Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice , 2003, Journal of Pharmacology and Experimental Therapeutics.

[333]  G. Gores,et al.  Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic , 2003, Laboratory Investigation.

[334]  Xiaoyan Zhu,et al.  Chronic ethanol consumption by mice results in activated splenic T cells , 2002, Journal of leukocyte biology.

[335]  G. Arteel,et al.  Role of Lipopolysaccharide-Binding Protein in Early Alcohol-Induced Liver Injury in Mice1 , 2002, The Journal of Immunology.

[336]  C. Day,et al.  Alcoholic liver disease: new insights into mechanisms and preventative strategies. , 2001, Trends in molecular medicine.

[337]  B. Cookson,et al.  Pro-inflammatory programmed cell death. , 2001, Trends in microbiology.

[338]  Thomas E. Moritz,et al.  Cell-mediated hepatic injury in alcoholic liver disease. Veterans Affairs Cooperative Study Group 275. , 1993, Gastroenterology.

[339]  M. M. Nass.  Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation. , 1973, Journal of molecular biology.

[340]  D. Pellicci,et al.  Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge , 2020 .

[341]  K. Kodys,et al.  MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. , 2018, Gastroenterology.

[342]  B. Gao,et al.  Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations , 2018, Nature Reviews Gastroenterology & Hepatology.

[343]  Liangguo Xu,et al.  IL-1 receptor like 1 protects against alcoholic liver injury by limiting NF-κB activation in hepatic macrophages. , 2017, Journal of hepatology.

[344]  A. Feldstein,et al.  In fl ammasomes in Liver Fibrosis , 2017 .

[345]  P. Shukla,et al.  Glutamine supplementation attenuates ethanol-induced disruption of apical junctional complexes in colonic epithelium and ameliorates gut barrier dysfunction and fatty liver in mice. , 2016, The Journal of nutritional biochemistry.

[346]  G. Szabo.  Gut-liver axis in alcoholic liver disease. , 2015, Gastroenterology.

[347]  Jamey D. Young,et al.  Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. , 2013, Progress in lipid research.

[348]  N. Lanthier,et al.  Kupffer cell activation is a causal factor for hepatic insulin resistance. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[349]  F. Violi,et al.  Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. , 2010, The New England journal of medicine.

[350]  T. Karlsen.  Genetic variation in PNPLA 3 confers susceptibility to nonalcoholic fatty liver disease , 2009 .

[351]  George Davey Smith,et al.  Supplementary Table S1 , 2008 .

[352]  L. Audoly,et al.  Toll-like receptor 9 – dependent activation by DNA-containing immune complexes is mediated by HMGB 1 and RAGE , 2007 .

[353]  P. Matzinger.  Tolerance, danger, and the extended family. , 1994, Annual review of immunology.

[354]  P. Bedossa,et al.  Ela fi branor , an Agonist of the Peroxisome Proliferator L Activated Receptor L a and L d , Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening , 2022 .