A state-of-the-art review comprising 40 chapters in seven sections, the book opens with a foreword by Dr. Joshua Lederberg. The body of the text features descriptions of the major mechanisms and the epidemiology of resistance and explores the current policy and education efforts toward maintaining drug efficacy. Special emphasis is placed on those areas where Dr. Levy stimulated scientific advancement through his own research and that of his students, research fellows, and colleagues. The chapters are unified in theme; however, each stands alone in conveying the author's individual perspectives regarding the issue of antimicrobial resistance.