AIDing antibody diversity by error-prone mismatch repair.

[1]  W. Edelmann,et al.  The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination , 2012, The Journal of experimental medicine.

[2]  A. Fischer,et al.  Human MSH6 Deficiency Is Associated with Impaired Antibody Maturation , 2012, The Journal of Immunology.

[3]  G. Almouzni,et al.  Interplay between mismatch repair and chromatin assembly , 2012, Proceedings of the National Academy of Sciences.

[4]  W. Edelmann,et al.  Mismatch-mediated error prone repair at the immunoglobulin genes. , 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[5]  A. Desai,et al.  Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates , 2011, Cell.

[6]  Zhongliang Ju,et al.  Interaction between the immunoglobulin heavy chain 3' regulatory region and the IgH transcription unit during B cell differentiation. , 2011, Molecular immunology.

[7]  Alberto Martin,et al.  The mismatch repair pathway functions normally at a non-AID target in germinal center B cells. , 2011, Blood.

[8]  C. E. Schrader,et al.  AID Binds Cooperatively with UNG and Msh2-Msh6 to Ig Switch Regions Dependent upon the AID C Terminus , 2011, The Journal of Immunology.

[9]  A. Durandy,et al.  Insights into the B cell specific process of immunoglobulin class switch recombination. , 2011, Immunology letters.

[10]  F. Alt,et al.  Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination , 2011, The Journal of experimental medicine.

[11]  A. Klein-Szanto,et al.  Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair , 2011, Cell.

[12]  J. Stavnezer Complex regulation and function of activation-induced cytidine deaminase. , 2011, Trends in immunology.

[13]  G. Ming,et al.  Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain , 2011, Cell.

[14]  J. Hoeijmakers,et al.  HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase. , 2011, DNA repair.

[15]  F. Alt,et al.  The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates , 2011, Cell.

[16]  Jayanta Chaudhuri,et al.  CtIP promotes microhomology-mediated alternative end-joining during class switch recombination , 2010, Nature Structural &Molecular Biology.

[17]  H. You,et al.  Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair , 2010, Nucleic acids research.

[18]  M. Nussenzweig,et al.  Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes , 2011, Nature Immunology.

[19]  H. Marusawa,et al.  Role of activation-induced cytidine deaminase in inflammation-associated cancer development. , 2011, Advances in immunology.

[20]  Hiromasa Inoue,et al.  The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in TH2 cells , 2011, Nature Immunology.

[21]  R. Chahwan,et al.  Crosstalk between genetic and epigenetic information through cytosine deamination. , 2010, Trends in genetics : TIG.

[22]  Vasco M. Barreto,et al.  Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5 , 2010, Cell.

[23]  J. Yates,et al.  14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination , 2010, Nature Structural &Molecular Biology.

[24]  K. Zhao,et al.  PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination , 2010, Science.

[25]  W. Edelmann,et al.  PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance , 2010, Proceedings of the National Academy of Sciences.

[26]  W. Edelmann,et al.  MSH2/MSH6 Complex Promotes Error-Free Repair of AID-Induced dU:G Mispairs as well as Error-Prone Hypermutation of A:T Sites , 2010, PloS one.

[27]  M. Lieber,et al.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. , 2010, Annual review of biochemistry.

[28]  M. Nussenzweig,et al.  Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 , 2010, The Journal of experimental medicine.

[29]  M. Pellegrini,et al.  Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency , 2010, Nature.

[30]  Helen M. Blau,et al.  Reprogramming towards pluripotency requires AID-dependent DNA demethylation , 2010, Nature.

[31]  Prashant Kodgire,et al.  Attracting AID to targets of somatic hypermutation , 2010, The Journal of experimental medicine.

[32]  Likun Du,et al.  Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching. , 2010, Advances in immunology.

[33]  A. Durandy,et al.  Inherited defects of immunoglobulin class switch recombination. , 2010, Advances in experimental medicine and biology.

[34]  R. Maul,et al.  AID and somatic hypermutation. , 2010, Advances in immunology.

[35]  Sarah Javaid,et al.  Nucleosome remodeling by hMSH2-hMSH6. , 2009, Molecular cell.

[36]  D. Durocher,et al.  The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination , 2009, Proceedings of the National Academy of Sciences.

[37]  P. V. D. van den Berk,et al.  Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation , 2009, The Journal of experimental medicine.

[38]  J. Bartek,et al.  The DNA-damage response in human biology and disease , 2009, Nature.

[39]  M. Wagner,et al.  DNA mismatch repair (MMR)‐dependent 5‐fluorouracil cytotoxicity and the potential for new therapeutic targets , 2009, British journal of pharmacology.

[40]  Alberto Martin,et al.  The Concerted Action of Msh2 and UNG Stimulates Somatic Hypermutation at A · T Base Pairs , 2009, Molecular and Cellular Biology.

[41]  D. Ferguson,et al.  Multiple functions of MRN in end-joining pathways during isotype class switching , 2009, Nature Structural &Molecular Biology.

[42]  P. Modrich,et al.  Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair* , 2009, The Journal of Biological Chemistry.

[43]  F. Delbos,et al.  A Backup Role of DNA Polymerase κ in Ig Gene Hypermutation Only Takes Place in the Complete Absence of DNA Polymerase η1 , 2009, The Journal of Immunology.

[44]  P. Kastner,et al.  Ikaros controls isotype selection during immunoglobulin class switch recombination , 2009, The Journal of experimental medicine.

[45]  M. Scharff,et al.  H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination , 2009, Proceedings of the National Academy of Sciences.

[46]  B. Cairns,et al.  DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 , 2008, Cell.

[47]  R. Ouchida,et al.  Induction of A:T Mutations Is Dependent on Cellular Environment but Independent of Mutation Frequency and Target Gene Location , 2008, The Journal of Immunology.

[48]  Likun Du,et al.  Non-homologous end joining in class switch recombination: the beginning of the end , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[49]  Marietta Y. W. T. Lee,et al.  PCNA is ubiquitinated by RNF8 , 2008, Cell cycle.

[50]  A. Fischer,et al.  Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination , 2008, The Journal of experimental medicine.

[51]  A. Bergman,et al.  Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression , 2008, Proceedings of the National Academy of Sciences.

[52]  S. Markowitz,et al.  Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks , 2008, Proceedings of the National Academy of Sciences.

[53]  J. Vijg,et al.  Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations. , 2008, DNA repair.

[54]  J. Blow,et al.  PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. , 2008, DNA repair.

[55]  Sergio Roa,et al.  The biochemistry of somatic hypermutation. , 2008, Annual review of immunology.

[56]  C. E. Schrader,et al.  Mechanism and regulation of class switch recombination. , 2008, Annual review of immunology.

[57]  D. Schatz,et al.  Two levels of protection for the B cell genome during somatic hypermutation , 2008, Nature.

[58]  E. Selsing,et al.  Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. , 2008, The Journal of Immunology.

[59]  T. Kunkel,et al.  Saccharomyces cerevisiae MutLα Is a Mismatch Repair Endonuclease* , 2007, Journal of Biological Chemistry.

[60]  G. Teng,et al.  Immunoglobulin somatic hypermutation. , 2007, Annual review of genetics.

[61]  F. Alt,et al.  S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. , 2007, Immunity.

[62]  Alberto Martin,et al.  Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AID , 2007, Molecular and Cellular Biology.

[63]  P. V. D. van den Berk,et al.  A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification , 2007, The Journal of experimental medicine.

[64]  M. Lieber,et al.  Sequence Dependence of Chromosomal R-Loops at the Immunoglobulin Heavy-Chain Sμ Class Switch Region , 2007, Molecular and Cellular Biology.

[65]  Ralph Schlapbach,et al.  Characterization of the Interactome of the Human MutL Homologues MLH1, PMS1, and PMS2* , 2007, Journal of Biological Chemistry.

[66]  F. Delbos,et al.  DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse , 2007, The Journal of experimental medicine.

[67]  Alberto Martin,et al.  Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation , 2007, The Journal of experimental medicine.

[68]  Mike O'Donnell,et al.  Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. , 2007, The Journal of biological chemistry.

[69]  T. Honjo,et al.  Role of AID in tumorigenesis. , 2007, Advances in immunology.

[70]  S. Markowitz,et al.  Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination , 2006, The Journal of cell biology.

[71]  S. Jentsch,et al.  A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation , 2006, PLoS biology.

[72]  Alberto Martin,et al.  AID Associates with Single-Stranded DNA with High Affinity and a Long Complex Half-Life in a Sequence-Independent Manner , 2006, Molecular and Cellular Biology.

[73]  D. Nicolae,et al.  Somatic Hypermutation and Class Switch Recombination in Msh6−/−Ung−/− Double-Knockout Mice1 , 2006, The Journal of Immunology.

[74]  P. Modrich Mechanisms in Eukaryotic Mismatch Repair* , 2006, Journal of Biological Chemistry.

[75]  P. Modrich,et al.  Endonucleolytic Function of MutLα in Human Mismatch Repair , 2006, Cell.

[76]  W. Edelmann,et al.  Mismatch repair proteins as sensors of alkylation DNA damage. , 2006, Cancer cell.

[77]  J. Jiricny The multifaceted mismatch-repair system , 2006, Nature Reviews Molecular Cell Biology.

[78]  W. Edelmann,et al.  The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. , 2006, Immunity.

[79]  P. Modrich,et al.  DNA mismatch repair: functions and mechanisms. , 2006, Chemical reviews.

[80]  A. Kenter,et al.  AID-dependent histone acetylation is detected in immunoglobulin S regions , 2006, The Journal of experimental medicine.

[81]  P. Modrich,et al.  Endonucleolytic function of MutLalpha in human mismatch repair. , 2006, Cell.

[82]  C. E. Schrader,et al.  Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination. , 2006, Trends in genetics : TIG.

[83]  U. Storb,et al.  Targeting of the Activation-Induced Cytosine Deaminase Is Strongly Influenced by the Sequence and Structure of the Targeted DNA , 2005, Molecular and Cellular Biology.

[84]  A. Tomkinson,et al.  Reconstitution of 5′-Directed Human Mismatch Repair in a Purified System , 2005, Cell.

[85]  E. Marcon,et al.  The evolution of meiosis: Recruitment and modification of somatic DNA‐repair proteins , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[86]  D. Schatz,et al.  Histone modifications associated with somatic hypermutation. , 2005, Immunity.

[87]  F. Hanaoka,et al.  Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[88]  M. Lieber,et al.  Fine-Structure Analysis of Activation-Induced Deaminase Accessibility to Class Switch Region R-Loops , 2005, Molecular and Cellular Biology.

[89]  F. Alt,et al.  An evolutionarily conserved target motif for immunoglobulin class-switch recombination , 2004, Nature Immunology.

[90]  M. Neuberger,et al.  Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. , 2004, Molecular cell.

[91]  U. Storb,et al.  Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[92]  A. Lehmann,et al.  Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. , 2004, Molecular cell.

[93]  P. Gearhart,et al.  Absence of DNA Polymerase η Reveals Targeting of C Mutations on the Nontranscribed Strand in Immunoglobulin Switch Regions , 2004, The Journal of experimental medicine.

[94]  D. Schatz,et al.  Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination. , 2004, International immunology.

[95]  Alberto Martin,et al.  Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice , 2004, Nature Immunology.

[96]  C. E. Schrader,et al.  Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination , 2003, The EMBO journal.

[97]  M. Veigl,et al.  A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage , 2003, Oncogene.

[98]  Alberto Martin,et al.  Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination , 2003, The Journal of experimental medicine.

[99]  Alberto Martin,et al.  Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. , 2003, Immunity.

[100]  U. Storb,et al.  The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. , 2003, Immunity.

[101]  F. Alt,et al.  Chromatin dynamics and locus accessibility in the immune system , 2003, Nature Immunology.

[102]  A. Bhagwat,et al.  Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. , 2003, Nucleic acids research.

[103]  P. Casali,et al.  AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation. , 2003, Immunity.

[104]  C. E. Schrader,et al.  Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2 , 2003, The Journal of experimental medicine.

[105]  M. Goodman,et al.  Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[106]  C. E. Schrader,et al.  Mlh 1 Can Function in Antibody Class Switch Recombination Independently of Msh 2 , 2003 .

[107]  D. Barnes,et al.  Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice , 2002, Current Biology.

[108]  Boris Pfander,et al.  RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO , 2002, Nature.

[109]  M. Neuberger,et al.  Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase , 2002, Nature.

[110]  B. Bertocci,et al.  AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line , 2002, Nature Immunology.

[111]  C. E. Schrader,et al.  Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions , 2002, The Journal of experimental medicine.

[112]  D. Nicolae,et al.  Effects of sequence and structure on the hypermutability of immunoglobulin genes. , 2002, Immunity.

[113]  K Bebenek,et al.  Error rate and specificity of human and murine DNA polymerase eta. , 2001, Journal of molecular biology.

[114]  A. Khamlichi,et al.  Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination. , 2001, Immunity.

[115]  P. Gearhart,et al.  DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes , 2001, Nature Immunology.

[116]  W. Edelmann,et al.  Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern , 2000, The Journal of experimental medicine.

[117]  R. Kucherlapati,et al.  Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes , 1999, The Journal of experimental medicine.

[118]  M. Neuberger,et al.  TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. , 1998, Immunity.

[119]  F. Alt,et al.  Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers , 1998, The Journal of experimental medicine.

[120]  C. Milstein,et al.  Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. , 1998, Immunity.

[121]  G. Kelsoe,et al.  Distinctive characteristics of germinal center B cells. , 1997, Seminars in immunology.