Ischemic preconditioning exaggerates cardiac damage in PKC-δ null mice

Ischemic preconditioning confers cardiac protection during subsequent ischemia-reperfusion, in which protein kinase C (PKC) is believed to play an essential role, but controversial data exist conce...

[1]  Manjeet Singh,et al.  Protein kinase C activation and cardioprotective effect of preconditioning with oxidative stress in isolated rat heart , 2001, Molecular and Cellular Biochemistry.

[2]  R. Jennings,et al.  Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. , 1986, Circulation.

[3]  Miller Mj.  Preconditioning for cardioprotection against ischemia reperfusion injury: the roles of nitric oxide, reactive oxygen species, heat shock proteins, reactive hyperemia and antioxidants--a mini review. , 2001 .

[4]  YigangWang,et al.  Downregulation of Protein Kinase C Inhibits Activation of Mitochondrial KATP Channels by Diazoxide , 2001 .

[5]  Michael V. Cohen,et al.  Protein Kinase C- ξ is Responsible for the Protection of Preconditioning in Rabbit Cardiomyocytes , 1999 .

[6]  Qingbo Xu,et al.  Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[7]  D. Fell,et al.  Regulation of Glycolytic Flux in Ischemic Preconditioning , 2002, The Journal of Biological Chemistry.

[8]  T. Nishimura,et al.  Role of Intracellular Na+ Kinetics in Preconditioned Rat Heart , 2001, Circulation research.

[9]  D. K. Arrell,et al.  Proteomic Analysis of Pharmacologically Preconditioned Cardiomyocytes Reveals Novel Phosphorylation of Myosin Light Chain 1 , 2001, Circulation research.

[10]  M. Chiariello,et al.  Oxygen radicals can induce preconditioning in rabbit hearts. , 1997, Circulation research.

[11]  D. N. Perkins,et al.  Probability‐based protein identification by searching sequence databases using mass spectrometry data , 1999, Electrophoresis.

[12]  R. Kloner,et al.  Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2. , 2001, Circulation.

[13]  G. Dorn,et al.  Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation , 1999 .

[14]  B. O’Rourke.  Myocardial KATP Channels in Preconditioning , 2000 .

[15]  A. Lane,et al.  Combined use of 1H-NMR and GC-MS for metabolite monitoring and in vivo 1H-NMR assignments. , 1986, Biochimica et biophysica acta.

[16]  W. Pierce,et al.  Formation of protein kinase Cε-Lck signaling modules confers cardioprotection , 2002 .

[17]  K. Davies,et al.  The oxidative inactivation of mitochondrial electron transport chain components and ATPase. , 1990, The Journal of biological chemistry.

[18]  G. Dorn,et al.  Ischemic Protection and Myofibrillar Cardiomyopathy: Dose-Dependent Effects of In Vivo &dgr;PKC Inhibition , 2002, Circulation research.

[19]  WeinaChen,et al.  A Redox-Based Mechanism for Cardioprotection Induced by Ischemic Preconditioning in Perfused Rat Heart , 1995 .

[20]  Yigang Wang,et al.  Essential activation of PKC-δ in opioid-initiated cardioprotection , 2001 .

[21]  W. Pierce,et al.  Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection. , 2002, The Journal of clinical investigation.

[22]  Hans Ulrich Bergmeyer,et al.  Methods of Enzymatic Analysis , 2019 .

[23]  W. Kübler,et al.  Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia. , 1999, Circulation research.

[24]  A. Shevchenko,et al.  Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. , 1996, Analytical chemistry.

[25]  R. Kloner,et al.  Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. , 2001, Circulation.

[26]  Qingbo Xu,et al.  Loss of PKC-δ alters cardiac metabolism , 2004 .

[27]  J. Mair,et al.  Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1. , 2001, Cardiovascular research.

[28]  K. Davies,et al.  Selective degradation of oxidatively modified protein substrates by the proteasome. , 2003, Biochemical and biophysical research communications.

[29]  B. Dietl,et al.  Bovine kidney pyruvate dehydrogenase complex. Isolation of the component enzymes after limited proteolysis with papain. , 1980, European journal of biochemistry.

[30]  S. Seino,et al.  Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice , 2002 .

[31]  R. Bolli,et al.  Demonstration of an early and a late phase of ischemic preconditioning in mice. , 1998, The American journal of physiology.

[32]  Qingbo Xu,et al.  Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways* , 1999, The Journal of Biological Chemistry.

[33]  A. Kowaltowski,et al.  Ischemic preconditioning inhibits mitochondrial respiration, increases H2O2 release, and enhances K+ transport. , 2003, American journal of physiology. Heart and circulatory physiology.

[34]  Qingbo Xu,et al.  Acute hypertension induces heat-shock protein 70 gene expression in rat aorta. , 1995, Circulation.

[35]  P. Ferdinandy,et al.  B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening. , 2003, American journal of physiology. Heart and circulatory physiology.

[36]  G. Kresze,et al.  Bovine kidney pyruvate dehydrogenase complex. Limited proteolysis and molecular structure of the lipoate acetyltransferase component. , 2005, European journal of biochemistry.

[37]  Qingbo Xu,et al.  Exacerbated vein graft arteriosclerosis in protein kinase Cδ–null mice , 2001 .

[38]  M. Ashraf,et al.  Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes. , 1996, Circulation.

[39]  G. Dorn,et al.  Additive Protection of the Ischemic Heart Ex Vivo by Combined Treatment With &dgr;-Protein Kinase C Inhibitor and &egr;-Protein Kinase C Activator , 2003 .

[40]  Andrew D. Miller,et al.  The Expression of Constitutively Active Isotypes of Protein Kinase C to Investigate Preconditioning* , 1998, The Journal of Biological Chemistry.

[41]  J. Powell,et al.  Identification and mapping of human saphenous vein medial smooth muscle proteins by two‐dimensional polyacrylamide gel electrophoresis , 2001, Proteomics.

[42]  Qingbo Xu,et al.  Mouse model of venous bypass graft arteriosclerosis. , 1998, The American journal of pathology.

[43]  Yigang Wang,et al.  PKC-δ inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats , 2002, Basic Research in Cardiology.

[44]  D. L. Miller,et al.  Ischemic preconditioning limits infarct size following regional ischemia-reperfusion in in situ mouse hearts. , 1999, Cardiovascular research.

[45]  A. Dana,et al.  The Preconditioning Phenomenon A Tool for the Scientist or a Clinical Reality ? , 2000 .

[46]  M. Mayr,et al.  Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. , 2001, The Journal of clinical investigation.

[47]  G. Dorn,et al.  Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[48]  R. Kloner,et al.  Differences in reperfusion length following 30 minutes of ischemia in the rabbit influence infarct size, as measured by triphenyltetrazolium chloride staining. , 1997, Journal of molecular and cellular cardiology.

[49]  G. Brooks,et al.  Role of protein kinase C in ischemic preconditioning: player or spectator? , 1996, Circulation research.

[50]  W. Chen,et al.  Ischemic Preconditioning Activates Phosphatidylinositol-3-Kinase Upstream of Protein Kinase C , 2000, Circulation research.

[51]  L. Szweda,et al.  Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. , 1998, Biochemistry.

[52]  M. Ashraf,et al.  Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium. , 1999, Circulation research.

[53]  R. Bolli.  The Late Phase of Preconditioning , 2000, Circulation research.

[54]  T. Vanden Hoek,et al.  Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes* , 1998, The Journal of Biological Chemistry.

[55]  J. Downey,et al.  Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes. , 1999, Journal of molecular and cellular cardiology.