The sex-specific associations of the aromatase gene with Alzheimer’s disease and its interaction with IL10 in the Epistasis Project

[1]  C. Pike,et al.  Gender, sex steroid hormones, and Alzheimer's disease , 2013, Hormones and Behavior.

[2]  M. Velders,et al.  Selective estrogen receptor‐β activation stimulates skeletal muscle growth and regeneration , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  P. Deloukas,et al.  Interaction of insulin and PPAR-α genes in Alzheimer’s disease: the Epistasis Project , 2012, Journal of Neural Transmission.

[4]  K. Jin,et al.  Estrogen, neuroprotection and neurogenesis after ischemic stroke. , 2012, Current drug targets.

[5]  E. Mufson,et al.  Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice , 2012, Neurobiology of Disease.

[6]  P. Ascenzi,et al.  Neuroprotective Effects of 17β-Estradiol Rely on Estrogen Receptor Membrane Initiated Signals , 2012, Front. Physio..

[7]  J. Lewis,et al.  A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture , 2011, BMC Medical Genetics.

[8]  L. Garcia-Segura,et al.  Neuroprotective actions of estradiol revisited , 2011, Trends in Endocrinology & Metabolism.

[9]  S. D. de Medeiros,et al.  Cellular and humoral immune responses after short-term oral hormone therapy in postmenopausal women , 2011, Climacteric : the journal of the International Menopause Society.

[10]  Manolis Kellis,et al.  HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants , 2011, Nucleic Acids Res..

[11]  D. Swaab,et al.  Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease , 2011, Neurobiology of Aging.

[12]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease , 2011, Neurology.

[13]  S. Yamawaki,et al.  Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration , 2011, Journal of toxicology.

[14]  J Zhang,et al.  The −1082G/A polymorphism in IL-10 gene is associated with risk of Alzheimer's disease: A meta-analysis , 2011, Journal of the Neurological Sciences.

[15]  C. Pike,et al.  Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease , 2011, Neurobiology of Aging.

[16]  D. Altshuler,et al.  A map of human genome variation from population-scale sequencing , 2010, Nature.

[17]  P. Wise,et al.  Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta. , 2010, Endocrinology.

[18]  Hideo Mukai,et al.  Modulation of synaptic plasticity by brain estrogen in the hippocampus. , 2010, Biochimica et biophysica acta.

[19]  F. Sohrabji,et al.  Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats , 2010, Neurobiology of Aging.

[20]  G. Gillies,et al.  Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines , 2010, Pharmacological Reviews.

[21]  F. Sohrabji,et al.  The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1 , 2010, The Journal of Neuroscience.

[22]  P. Guyre,et al.  Estradiol Suppresses NF-κB Activation through Coordinated Regulation of let-7a and miR-125b in Primary Human Macrophages , 2010, The Journal of Immunology.

[23]  H. Offner,et al.  GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol , 2010, BMC Immunology.

[24]  J. Ragoussis,et al.  Association of the aromatase gene with Alzheimer's disease in women , 2010, Neuroscience Letters.

[25]  Mario Cortina-Borja,et al.  Open Access Journal of Neuroinflammation Replication by the Epistasis Project of the Interaction between the Genes for Il-6 and Il-10 in the Risk of Alzheimer's Disease , 2022 .

[26]  G. Moretto,et al.  Genetic Variation of CYP19 (Aromatase) Gene Influences Age at Onset of Alzheimer’s Disease in Women , 2009, Dementia and Geriatric Cognitive Disorders.

[27]  Andrew D. Johnson,et al.  SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap , 2008, Bioinform..

[28]  Roberta Diaz Brinton,et al.  Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. , 2008, Advanced drug delivery reviews.

[29]  R. Brinton,et al.  The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications , 2008, Trends in Neurosciences.

[30]  H. A. Harris,et al.  Selective estrogen receptor-β agonists repress transcription of proinflammatory genes , 2008, The Journal of Immunology.

[31]  J. Simpkins,et al.  Mitochondrial mechanisms of estrogen neuroprotection , 2008, Brain Research Reviews.

[32]  O. Combarros,et al.  Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer’s disease risk , 2008, Journal of Neural Transmission.

[33]  D. Tatomer,et al.  Selective Estrogen Receptor-β Agonists Repress Transcription of Proinflammatory Genes1 , 2008, The Journal of Immunology.

[34]  F. Morón,et al.  Sex and Body Mass Index Specific Regulation of Blood Pressure by CYP19A1 Gene Variants , 2007, Hypertension.

[35]  I. Loy-English,et al.  Gender differences in dementia risk factors. , 2007, Gender medicine.

[36]  S. Sorbi,et al.  Association of IL10 promoter polymorphism in Italian Alzheimer's disease , 2007, Neuroscience Letters.

[37]  D. Brann,et al.  Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications , 2007, Steroids.

[38]  D. Altshuler,et al.  Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. , 2007, Cancer research.

[39]  J. DeFelipe,et al.  Aromatase expression in the human temporal cortex , 2006, Neuroscience.

[40]  Tony Wyss-Coray,et al.  Inflammation in Alzheimer disease: driving force, bystander or beneficial response? , 2006, Nature Medicine.

[41]  S. Poduslo,et al.  CYP19 haplotypes increase risk for Alzheimer’s disease , 2006, Journal of Medical Genetics.

[42]  L. K. Marriott,et al.  Multiple pathways transmit neuroprotective effects of gonadal steroids , 2006, Endocrine.

[43]  A. Członkowska,et al.  Gender differences in neurological disease , 2006, Endocrine.

[44]  Rena Li,et al.  Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[45]  O. Combarros,et al.  Interaction between CYP19 Aromatase and Butyrylcholinesterase Genes Increases Alzheimer’s Disease Risk , 2005, Dementia and Geriatric Cognitive Disorders.

[46]  C. Brayne,et al.  The Incidence of Dementia in England and Wales: Findings from the Five Identical Sites of the MRC CFA Study , 2005, PLoS medicine.

[47]  H. Chiu,et al.  The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease , 2005, Neurobiology of Aging.

[48]  A. Bruce-Keller,et al.  Estrogen and brain inflammation: Effects on microglial expression of MHC, costimulatory molecules and cytokines , 2005, Journal of Neuroimmunology.

[49]  D. Murphy,et al.  The Women's Health Initiative Memory Study: findings and implications for treatment , 2005, The Lancet Neurology.

[50]  E. Hol,et al.  Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer’s disease , 2005, Neurobiology of Aging.

[51]  B. Ponder,et al.  Polymorphisms associated with circulating sex hormone levels in postmenopausal women. , 2005, Journal of the National Cancer Institute.

[52]  C. Burge,et al.  Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.

[53]  D. Giordano,et al.  17-ß-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells Short title: The effect of 17-ß-estradiol on dendritic cells , 2004 .

[54]  Ivan Ovcharenko,et al.  ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes , 2004, Nucleic Acids Res..

[55]  Michael Frotscher,et al.  Hippocampal Synapses Depend on Hippocampal Estrogen Synthesis , 2004, The Journal of Neuroscience.

[56]  P. Kramer,et al.  17β‐estradiol regulates cytokine release through modulation of CD16 expression in monocytes and monocyte‐derived macrophages , 2004 .

[57]  E. Corder,et al.  Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease , 2004, Neurology.

[58]  E. Hogervorst,et al.  The Controversy Over Levels of Sex Steroids in Cases with Alzheimer's Disease , 2004, Journal of neuroendocrinology.

[59]  C. Ulrich,et al.  Association of CYP17, CYP19, CYP1B1, and COMT Polymorphisms with Serum and Urinary Sex Hormone Concentrations in Postmenopausal Women , 2004, Cancer Epidemiology Biomarkers & Prevention.

[60]  B. Stoffel‐Wagner Neurosteroid Biosynthesis in the Human Brain and Its Clinical Implications , 2003, Annals of the New York Academy of Sciences.

[61]  L. Garcia-Segura,et al.  Aromatase Expression by Reactive Astroglia Is Neuroprotective , 2003, Annals of the New York Academy of Sciences.

[62]  Arto Mannermaa,et al.  Apolipoprotein E 4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease , 2002, Annals of Internal Medicine.

[63]  Rena Li,et al.  Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients , 2002, Journal of neurochemistry.

[64]  F. Ross,et al.  Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. , 1999, The Journal of clinical investigation.

[65]  D Commenges,et al.  Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project , 1999, Journal of neurology, neurosurgery, and psychiatry.

[66]  A. Hofman,et al.  Incidence and risk of dementia. The Rotterdam Study. , 1998, American journal of epidemiology.

[67]  M. Lazarus,et al.  An investigation of polymorphism in the interleukin-10 gene promoter. , 1997, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

[68]  B. Winblad,et al.  Very Old Women at Highest Risk of Dementia and Alzheimer's Disease , 1997, Neurology.

[69]  R. D'Agostino,et al.  Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. , 1993, American journal of epidemiology.

[70]  S. M. Sumi,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) , 1991, Neurology.

[71]  C. Caruso,et al.  Association between interleukin-10 polymorphisms and Alzheimer's disease: a systematic review and meta-analysis. , 2012, Journal of Alzheimer's disease : JAD.

[72]  D. Selkoe Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[73]  Mario Cortina-Borja,et al.  The synergy factor: a statistic to measure interactions in complex diseases , 2009, BMC Research Notes.

[74]  R. Brinton,et al.  Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. , 2008, Endocrinology.

[75]  D. Swaab,et al.  Estrogen receptor alpha and its splice variants in the hippocampus in aging and Alzheimer's disease. , 2007, Neurobiology of aging.

[76]  P. Lønning,et al.  Genetic variants of CYP19 (aromatase) and breast cancer risk , 2000, Oncogene.