Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft

[1]  R. Guldberg,et al.  Oxidized alginate hydrogels for bone morphogenetic protein-2 delivery in long bone defects. , 2014, Acta biomaterialia.

[2]  Nicola Maffulli,et al.  Bone regenerative medicine: classic options, novel strategies, and future directions , 2014, Journal of Orthopaedic Surgery and Research.

[3]  Dong-Guk Shin,et al.  Computer-Automated Static, Dynamic and Cellular Bone Histomorphometry , 2012, Journal of tissue science & engineering.

[4]  D. Hutmacher,et al.  A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones , 2012, Science Translational Medicine.

[5]  R. Guldberg,et al.  Effects of in vivo mechanical loading on large bone defect regeneration , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  W. Virkus,et al.  Healing of rat femoral segmental defect with bone morphogenetic protein-2: a dose response study. , 2012, Journal of musculoskeletal & neuronal interactions.

[7]  D. Hutmacher,et al.  Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects. , 2011, Bone.

[8]  R. Guldberg,et al.  Mechanical regulation of vascular growth and tissue regeneration in vivo , 2011, Proceedings of the National Academy of Sciences.

[9]  Andrés J. García,et al.  Effects of protein dose and delivery system on BMP-mediated bone regeneration. , 2011, Biomaterials.

[10]  Benjamin M Wu,et al.  High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. , 2011, Tissue engineering. Part A.

[11]  F. Hefti,et al.  The outcome of pelvic reconstruction with non-vascularised fibular grafts after resection of bone tumours. , 2010, The Journal of bone and joint surgery. British volume.

[12]  Xi Jiang,et al.  Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage , 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[13]  Wouter J A Dhert,et al.  Use of fluorochrome labels in in vivo bone tissue engineering research. , 2010, Tissue engineering. Part B, Reviews.

[14]  J. M. Badura,et al.  Improved Healing Efficacy in Canine Ulnar Segmental Defects With Increasing Recombinant Human Bone Morphogenetic Protein-2/Allograft Ratios , 2008, Journal of orthopaedic trauma.

[15]  David J Mooney,et al.  Quantitative assessment of scaffold and growth factor‐mediated repair of critically sized bone defects , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  O. Cornu,et al.  Are bone autografts still necessary in 2006? A three-year retrospective study of bone grafting. , 2006, Acta orthopaedica Belgica.

[17]  W. R. Taylor,et al.  Impaired Angiogenesis, Early Callus Formation, and Late Stage Remodeling in Fracture Healing of Osteopontin‐Deficient Mice , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  S. Mirza,et al.  Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. , 2006, The Journal of bone and joint surgery. American volume.

[19]  S. Glassman,et al.  Adverse Effects Associated With High-Dose Recombinant Human Bone Morphogenetic Protein-2 Use in Anterior Cervical Spine Fusion , 2006, Spine.

[20]  Stefan Milz,et al.  Polychrome labeling of bone with seven different fluorochromes: enhancing fluorochrome discrimination by spectral image analysis. , 2005, Bone.

[21]  Alen Braut,et al.  Histological Analysis of GFP Expression in Murine Bone , 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[22]  Eben Alsberg,et al.  Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. , 2004, Bone.

[23]  D J Mooney,et al.  Regulating Bone Formation via Controlled Scaffold Degradation , 2003, Journal of dental research.

[24]  S. Santavirta,et al.  Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty Patients , 2002, The Journal of bone and joint surgery. American volume.

[25]  S. Govender,et al.  Staged reduction and stabilisation in chronic atlantoaxial rotatory fixation. , 2002, The Journal of bone and joint surgery. British volume.

[26]  C. Finkemeier,et al.  Bone-grafting and bone-graft substitutes. , 2002, The Journal of bone and joint surgery. American volume.

[27]  P. Simon,et al.  Perforations of Cortical Bone Allografts Improve Their Incorporation , 2002, Clinical orthopaedics and related research.

[28]  K W Anderson,et al.  Cell-interactive Alginate Hydrogels for Bone Tissue Engineering , 2001, Journal of dental research.

[29]  V. Frenkel,et al.  Visualizing normal and defective bone development in zebrafish embryos using the fluorescent chromophore calcein. , 2001, Developmental biology.

[30]  H. Seeherman,et al.  Histomorphometric description of allograft bone remodeling and union in a canine segmental femoral defect model: A comparison of rhBMP‐2, cancellous bone graft, and absorbable collagen sponge , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[31]  K. Johnson,et al.  Evaluation of recombinant human bone morphogenetic protein‐2 as a bone‐graft substitute in a canine segmental defect model , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[32]  T. Beck,et al.  A study of different calcification areas in newly formed bone 8 weeks after insertion of dental implants in rabbit tibias. , 1998, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[33]  Diane L. Sterehi,et al.  Modified Mallory Aniline Blue Stain for Bone, Cartilage, and Other Connective Tissues , 1998 .

[34]  E. Vuorio,et al.  Gene expression at graft-host interfaces of cortical bone allografts and autografts. , 1993, Clinical orthopaedics and related research.

[35]  R. Jinnah,et al.  The biology of bone grafting. , 1991, Orthopedics.

[36]  V. Goldberg,et al.  Natural history of autografts and allografts. , 1987, Clinical orthopaedics and related research.

[37]  R. Burwell The Function of Bone Marrow in the Incorporation of a Bone Graft , 1985, Clinical orthopaedics and related research.

[38]  Burwell Rg,et al.  The function of bone marrow in the incorporation of a bone graft. , 1985 .

[39]  W. Enneking,et al.  Autogenous cortical bone grafts in the reconstruction of segmental skeletal defects. , 1980, The Journal of bone and joint surgery. American volume.

[40]  K. J. Anderson The behavior of autogenous and homogenous bone transplants in the anterior chamber of the rat's eye. A histological study of the effect of the size of the implant. , 1961, The Journal of bone and joint surgery. American volume.

[41]  K. J. Anderson,et al.  The effect of particle size of the heterogenous-bone transplant on the host-tissue vascular penetration. , 1959, The Journal of bone and joint surgery. American volume.

[42]  R. Guldberg,et al.  Effect of cell origin and timing of delivery for stem cell-based bone tissue engineering using biologically functionalized hydrogels. , 2015, Tissue engineering. Part A.

[43]  David J Mooney,et al.  An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. , 2011, Biomaterials.

[44]  D. Rowe,et al.  Examination of Mineralized Nodule Formation in Living Osteoblastic Cultures Using Fluorescent Dyes , 2006, Biotechnology progress.

[45]  H. Selek,et al.  [Nonvascularized fibular grafts in the reconstruction of bone defects in orthopedic oncology]. , 2005, Acta orthopaedica et traumatologica turcica.

[46]  D J Mooney,et al.  Alginate hydrogels as synthetic extracellular matrix materials. , 1999, Biomaterials.

[47]  K. Johnson,et al.  Evaluation of ground cortical autograft as a bone graft material in a new canine bilateral segmental long bone defect model. , 1996, Journal of orthopaedic trauma.

[48]  J. Older Bone Implant Grafting , 1992, Springer London.

[49]  M. Chapman,et al.  Morbidity at bone graft donor sites. , 1989, Journal of orthopaedic trauma.

[50]  H. Burchardt Biology of Cortical Bone Graft Incorporation , 1989 .