Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs

[1]  G. Karakaya,et al.  Synthesis and Molecular Modeling of Some Novel Hydroxypyrone Derivatives as Antidermatophytic Agents , 2022, Journal of Heterocyclic Chemistry.

[2]  L. Zhong,et al.  Small molecules in targeted cancer therapy: advances, challenges, and future perspectives , 2021, Signal Transduction and Targeted Therapy.

[3]  Cleison C. Lobato,et al.  Molecular modification approach on kojic acid derivatives as antioxidants related to ascorbic acid , 2020, Journal of Molecular Modeling.

[4]  H. Ansari,et al.  An investigation of the effects of environmental and ecologic factors on cutaneous leishmaniasis in the old world: a systematic review study , 2020, Reviews on environmental health.

[5]  S. Jokar,et al.  Comparison of Deferoxamine, Deferiprone and Deferasirox Iron-Chelating Agents in Reducing Serum Ferritin Levels in Patients with Thalassemia Major , 2020, Journal of Clinical Care and Skills.

[6]  J. Selvin,et al.  Revealing antibiotic resistance in therapeutic and dietary probiotic supplements. , 2020, Journal of global antimicrobial resistance.

[7]  E. Beghi The Epidemiology of Epilepsy , 2019, Neuroepidemiology.

[8]  L. Zuo,et al.  Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments , 2019, International journal of molecular sciences.

[9]  Wei Lu,et al.  Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations. , 2019, European journal of medicinal chemistry.

[10]  Miri Lee,et al.  Anti-inflammatory Effects of a P-coumaric Acid and Kojic Acid Derivative in LPS-stimulated RAW264.7 Macrophage Cells , 2019, Biotechnology and Bioprocess Engineering.

[11]  S. Saran,et al.  Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk , 2019, Molecular Biology Reports.

[12]  A. Daryani,et al.  In vitro and in vivo evaluation of kojic acid against Toxoplasma gondii in experimental models of acute toxoplasmosis. , 2019, Experimental parasitology.

[13]  M. Peana,et al.  A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays. , 2019, Journal of inorganic biochemistry.

[14]  M. Saeedi,et al.  Kojic acid applications in cosmetic and pharmaceutical preparations. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[15]  Qing-Xi Chen,et al.  Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents , 2019, Journal of enzyme inhibition and medicinal chemistry.

[16]  D. Jun,et al.  Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy , 2018, Journal of enzyme inhibition and medicinal chemistry.

[17]  Yu-gang Shi,et al.  Evaluation of antibacterial and anti-biofilm properties of kojic acid against five food-related bacteria and related subcellular mechanisms of bacterial inactivation , 2018, Food science and technology international = Ciencia y tecnologia de los alimentos internacional.

[18]  E. Giovannetti,et al.  Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance. , 2019, European journal of medicinal chemistry.

[19]  Jia-hui Yu,et al.  Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors. , 2018, European journal of medicinal chemistry.

[20]  L. Peixe,et al.  New fluorescent rosamine chelator showing promising antibacterial activity against Gram-positive bacteria. , 2018, Bioorganic chemistry.

[21]  W. Xia,et al.  One-step procedure for enhancing the antibacterial and antioxidant properties of a polysaccharide polymer: Kojic acid grafted onto chitosan. , 2018, International journal of biological macromolecules.

[22]  E. Telleria,et al.  Leishmania, microbiota and sand fly immunity , 2018, Parasitology.

[23]  Y. Taufiq-Yap,et al.  The crucial roles of inflammatory mediators in inflammation: A review , 2018, Veterinary world.

[24]  Wei-Min Chen,et al.  Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4H-pyran-4-one derivatives as antiglioma agents. , 2018, MedChemComm.

[25]  B. Farhood,et al.  Incidence and Mortality of Various Cancers in Iran and Compare to Other Countries: A Review Article , 2018, Iranian journal of public health.

[26]  A. Fassihi,et al.  Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands , 2018, Research in pharmaceutical sciences.

[27]  S. Emami,et al.  New indole-based chalconoids as tubulin-targeting antiproliferative agents. , 2017, Bioorganic chemistry.

[28]  M. Keighobadi,et al.  An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. , 2017, European journal of medicinal chemistry.

[29]  Shao-Cong Sun,et al.  NF-κB signaling in inflammation , 2017, Signal Transduction and Targeted Therapy.

[30]  Wenjing Chu,et al.  Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections. , 2017, Journal of medicinal chemistry.

[31]  R. Sheng,et al.  Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ1-42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease. , 2017, European journal of medicinal chemistry.

[32]  A. Majeed,et al.  Brain biometals and Alzheimer's disease – boon or bane? , 2017, The International journal of neuroscience.

[33]  Xiaole Kong,et al.  Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones - Attempted optimization of the orally active iron chelator, deferiprone. , 2016, European journal of medicinal chemistry.

[34]  J. Seo,et al.  Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent. , 2015, Bioorganic & medicinal chemistry letters.

[35]  M. Zirak,et al.  Kojic acid in organic synthesis , 2015 .

[36]  S. Ulusoy,et al.  Inhibition of Pseudomonas aeruginosa biofilm formation by 2,2’-bipyridyl, lipoic, kojic and picolinic acids , 2015, Iranian journal of basic medical sciences.

[37]  J. Nanubolu,et al.  One-pot catalyst free synthesis of novel kojic acid tagged 2-aryl/alkyl substituted-4H-chromenes and evaluation of their antimicrobial and anti-biofilm activities. , 2015, Bioorganic & medicinal chemistry letters.

[38]  S. Emami,et al.  Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity , 2015 .

[39]  O. Hansson,et al.  β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease , 2014, Neurotherapeutics.

[40]  Shaoshan Li,et al.  Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action. , 2014, International journal of oncology.

[41]  A. Tamrakar,et al.  Synthesis of heteroaryl/aryl kojic acid conjugates as stimulators of glucose uptake by GLUT4 translocation. , 2014, European journal of medicinal chemistry.

[42]  M. Faramarzi,et al.  Mannich Bases of 7‐Piperazinylquinolones and Kojic Acid Derivatives: Synthesis, in vitro Antibacterial Activity and in silico Study. , 2014 .

[43]  A. Santos,et al.  A Novel Function for Kojic Acid, a Secondary Metabolite from Aspergillus Fungi, as Antileishmanial Agent , 2014, PloS one.

[44]  Yanshun Xu,et al.  Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide. , 2014, Journal of agricultural and food chemistry.

[45]  M. Crespo-Alonso,et al.  Searching for new aluminium chelating agents: a family of hydroxypyrone ligands. , 2014, Journal of inorganic biochemistry.

[46]  M. Crespo-Alonso,et al.  A family of hydroxypyrone ligands designed and synthesized as iron chelators. , 2013, Journal of inorganic biochemistry.

[47]  M. Faramarzi,et al.  Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. , 2013, European journal of medicinal chemistry.

[48]  O. Firuzi,et al.  Cytotoxic activity assessment, QSAR and docking study of novel bis-carboxamide derivatives of 4-pyrones synthesized by Ugi four-component reaction. , 2013, European journal of medicinal chemistry.

[49]  M. Jakupec,et al.  Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate. , 2013, Chemistry.

[50]  Hai-bin Luo,et al.  Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. , 2013, Journal of medicinal chemistry.

[51]  V. Shanmugasundaram,et al.  Pyridone-conjugated monobactam antibiotics with gram-negative activity. , 2013, Journal of medicinal chemistry.

[52]  G. Karakaya,et al.  Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity. , 2013, Bioorganic & medicinal chemistry letters.

[53]  P. T. Perumal,et al.  Cu(OTf)2 catalyzed three component reaction: efficient synthesis of spiro[indoline-3,4'-pyrano[3,2-b]pyran derivatives and their anticancer potency towards A549 human lung cancer cell lines. , 2013, Bioorganic & medicinal chemistry letters.

[54]  G. Karakaya,et al.  Design, synthesis and in vivo/in vitro screening of novel chlorokojic acid derivatives , 2013, Journal of enzyme inhibition and medicinal chemistry.

[55]  B. Campbell,et al.  Enhancement of Commercial Antifungal Agents by Kojic Acid , 2012, International journal of molecular sciences.

[56]  C. Hulme,et al.  Synthesis of kojic acid-derived copper-chelating apoptosis inducing agents , 2012, Medicinal Chemistry Research.

[57]  S. Shin,et al.  Studies on Tyrosinase Inhibitory and Antioxidant Activities of Benzoic Acid Derivatives Containing Kojic Acid Moiety , 2011 .

[58]  Xiaole Kong,et al.  Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents. , 2011, Bioorganic & medicinal chemistry letters.

[59]  J. Cho,et al.  Ester Derivatives of Kojic Acid and Polyphenols Containing Adamantane Moiety with Tyrosinase Inhibitory and Anti-inflammatory Properties , 2011 .

[60]  T. Gootz,et al.  Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols. , 2011, ACS medicinal chemistry letters.

[61]  B. Özçelik,et al.  Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives , 2011, Medicinal Chemistry Research.

[62]  B. Reddy,et al.  Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. , 2010, Bioorganic & medicinal chemistry letters.

[63]  M. Aytemir,et al.  A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities. , 2010, European journal of medicinal chemistry.

[64]  J. Cho,et al.  A modulatory effect of novel kojic acid derivatives on cancer cell proliferation and macrophage activation. , 2010, Die Pharmazie.

[65]  M. Aytemir,et al.  Anticonvulsant and Neurotoxicity Evaluation of Some Novel Kojic Acids and Allomaltol Derivatives , 2010, Archiv der Pharmazie.

[66]  I. Kurnaz,et al.  4H-Pyran-4-one derivatives:; leading molecule for preparation of compounds with antimycobacterial potential , 2009 .

[67]  C. Glabe,et al.  Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction , 2009, Neurobiology of Disease.

[68]  S. Hosseinimehr,et al.  Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice. , 2009, Saudi medical journal.

[69]  H. Waldmann,et al.  Gamma-pyrone natural products--a privileged compound class provided by nature. , 2009, Bioorganic & medicinal chemistry.

[70]  R. Hider,et al.  Iron chelation as a potential therapy for neurodegenerative disease. , 2008, Biochemical Society transactions.

[71]  J. Brtko,et al.  In vitro antiproliferative and cytotoxic activities of novel kojic acid derivatives: 5‐benzyloxy‐2‐selenocyanatomethyl‐ and 5‐methoxy‐2‐selenocyanatomethyl‐4‐pyranone , 2008, Journal of applied toxicology : JAT.

[72]  S. M. Taghdisi,et al.  Kojic acid and its manganese and zinc complexes as potential radioprotective agents. , 2007, Bioorganic & medicinal chemistry letters.

[73]  M. Camplo,et al.  Novel iron-specific fluorescent probes. , 2005, Bioorganic & medicinal chemistry letters.

[74]  M. Özalp,et al.  Synthesis and Evaluation of Anticonvulsant and Antimicrobial Activities of 3‐Hydroxy‐6‐methyl‐2‐substituted 4H‐Pyran‐4‐one Derivatives , 2004, Archiv der Pharmazie.

[75]  E. Giacobini Cholinesterases: New Roles in Brain Function and in Alzheimer's Disease , 2003, Neurochemical Research.

[76]  R. Hider,et al.  Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H -pyran-2- carboxamide Derivatives , 2003 .

[77]  R. Hider,et al.  Synthesis of New Antimicrobial Agents; Amide Derivatives of Pyranones and Pyridinones , 2003 .

[78]  L. Novotný,et al.  Antileukemic activity of 4-pyranone derivatives. , 1995, The international journal of biochemistry & cell biology.

[79]  P. Watkins,et al.  Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. , 1994, JAMA.

[80]  J. L. Vaught,et al.  An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA). , 1987, Neuropharmacology.

[81]  J. Rokach,et al.  Kojic amine--a novel gamma-aminobutyric acid analogue. , 1979, Journal of medicinal chemistry.

[82]  T. Fujita,et al.  Structure-activity Study of Bacteriostatic Kojic Acid Analogs , 1975 .