Monocyte‐mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by β‐integrin

Red blood cell (RBC) transfusion is associated with organ failure. The mechanism remains unknown, but may include adherence of blood cells to the microvasculature. We hypothesized that RBC‐derived extracellular vesicles (EVs) interact with monocytes to activate endothelial cells.

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