XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers.

X-ray repair cross-complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base excision repair (BER) and single-strand break repair (SSBR) pathway. Single nucleotide polymorphisms (SNPs) in XRCC1 may alter protein function and repair capacity, thus lead to genetic instability and carcinogenesis. To establish our understanding of possible relationships between XRCC1 polymorphisms (5'UTR -77T>C, Arg194Trp, Arg280His and Arg399Gln) and the susceptibility to lung cancer among women nonsmokers, we performed a hospital-based case-control study of 350 patients with newly diagnosed lung cancer and 350 cancer-free controls, frequency matched by age. Our results showed that exposure to cooking oil fume was associated with increased risk of lung cancer in Chinese women nonsmokers [odds ratio (OR)=2.51, 95% confidence interval (CI) [1.80-3.51], P<0.001]. Individuals with homozygous XRCC1 399Gln/Gln genotype (OR=1.75, 95% CI [1.02-3.01]) and XRCC1 -77 combined TC and CC genotype (OR=1.66, 95% CI [1.13-2.42]) showed a slightly higher risk for lung cancer overall. In the subgroup of adenocarcinoma cases, adjusted ORs were increased for individuals with homozygous XRCC1 399Gln/Gln genotype (OR=2.62, 95% CI [1.44-4.79]) and XRCC1 -77 combined TC and CC genotype (OR=1.85, 95% CI [1.19-2.86]). Haplotype analysis showed that T-Trp-Arg-Gln haplotypes were associated with an increased risk of lung cancer among women nonsmokers (OR=2.26, 95% CI [1.38-3.68]), however, we did not observe a statistically significant joint effect of cooking oil fume and 399Gln or -77C variant allele on lung cancer among women nonsmokers. In conclusion, XRCC1 Arg399Gln and T-77C polymorphisms may alter the risk of lung cancer in women nonsmokers in China.

[1]  D. Tang,et al.  DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. , 2002, Carcinogenesis.

[2]  D. Bell,et al.  Advances in Brief XRCC 1 Polymorphisms : Effects on Aflatoxin B 1-DNA Adducts and Glycophorin A Variant Frequency , 2000 .

[3]  E. Petermann,et al.  Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER. , 2006, DNA repair.

[4]  P Vineis,et al.  XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. , 2001, Carcinogenesis.

[5]  Jolanta Lissowska,et al.  Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study. , 2005, Journal of the National Cancer Institute.

[6]  T. Chiang,et al.  Identification of carcinogens in cooking oil fumes. , 1999, Environmental research.

[7]  M. Tockman,et al.  Polymorphisms of the DNA Repair Gene XRCC 1 and Lung Cancer Risk , 2001 .

[8]  M. Spitz,et al.  From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. , 2003, DNA repair.

[9]  D. Kang,et al.  Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk. , 2004, Carcinogenesis.

[10]  I. Hickson,et al.  XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions , 2001, The EMBO journal.

[11]  Jinshui Fan,et al.  XRCC1 co-localizes and physically interacts with PCNA. , 2004, Nucleic acids research.

[12]  I. M. Jones,et al.  Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. , 1998, Cancer research.

[13]  Yong-yong Shi,et al.  SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci , 2023, Cell Research.

[14]  M. Tockman,et al.  Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[15]  D. Campa,et al.  Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. , 2006, Carcinogenesis.

[16]  M. Masson,et al.  XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage , 1998, Molecular and Cellular Biology.

[17]  D. Barnes,et al.  Reconstitution of DNA base excision‐repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. , 1996, The EMBO journal.

[18]  Y. Nakanishi,et al.  Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis. , 2006, Lung cancer.

[19]  Jun Nakamura,et al.  The Arg280His polymorphism in X-ray repair cross-complementing gene 1 impairs DNA repair ability. , 2005, Mutation research.

[20]  M. Weinfeld,et al.  XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair , 2001, Cell.

[21]  N. Rothman,et al.  Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. , 2005, Anticancer research.

[22]  L. Thompson,et al.  An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III , 1994, Molecular and cellular biology.

[23]  G. de Murcia,et al.  Role of XRCC1 in the Coordination and Stimulation of Oxidative DNA Damage Repair Initiated by the DNA Glycosylase hOGG1* , 2003, Journal of Biological Chemistry.

[24]  Christopher I Amos,et al.  Genetic susceptibility to lung cancer: the role of DNA damage and repair. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[25]  S. Z. Abdel‐Rahman,et al.  The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK. , 2000, Cancer letters.

[26]  G. Dianov,et al.  XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. , 2004, Nucleic acids research.

[27]  Xingzhou He,et al.  Smoking and other risk factors for lung cancer in Xuanwei, China. , 1991, International journal of epidemiology.

[28]  J. Fraumeni,et al.  Lung cancer among Chinese women , 1987, International journal of cancer.

[29]  H. Koong,et al.  Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[30]  Hongbing Shen,et al.  A promoter polymorphism (−77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking , 2005, Pharmacogenetics and genomics.

[31]  Zou Xiao-nong,et al.  Epidemiology of lung cancer in China , 2007 .

[32]  C. H. Kim,et al.  Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[33]  D. Christiani,et al.  Polymorphisms in the DNA Repair Genes XRCC 1 and ERCC 2 , Smoking , and Lung Cancer Risk 1 , 2003 .

[34]  D. Cox,et al.  The XRCC 1 77 T ! C variant : haplotypes , breast cancer risk , response to radiotherapy and the cellular response to DNA damage , 2006 .

[35]  H. Thierens,et al.  Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. , 2007, Mutation research.

[36]  Q. Wei,et al.  Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. , 2005, Cancer research.

[37]  H. Dienemann,et al.  Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. , 2004, Carcinogenesis.

[38]  K. Caldecott,et al.  XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. , 1996, Nucleic acids research.

[39]  Q. Wei,et al.  A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer , 2006, Oncogene.

[40]  D. Cox,et al.  The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage. , 2006, Carcinogenesis.

[41]  S. Mayne,et al.  Previous lung disease and risk of lung cancer among men and women nonsmokers. , 1999, American journal of epidemiology.

[42]  S. London,et al.  Genetic polymorphism of XRCC1 and lung cancer risk among African-Americans and Caucasians. , 2001, Lung cancer.

[43]  D. Christiani,et al.  Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[44]  J. Schneider,et al.  XRCC1 polymorphism and lung cancer risk in relation to tobacco smoking. , 2005, International journal of molecular medicine.

[45]  Baosen Zhou,et al.  [Association of genetic polymorphism in the DNA repair gene XRCC1 with susceptibility to lung cancer in non-smoking women]. , 2005, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[46]  Y. Ko,et al.  Chinese food cooking and lung cancer in women nonsmokers. , 2000, American journal of epidemiology.

[47]  Wen Tan,et al.  Identification of Genetic Variants in Base Excision Repair Pathway and Their Associations with Risk of Esophageal Squamous Cell Carcinoma , 2004, Cancer Research.

[48]  F. Clavel-Chapelon,et al.  DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. , 2006, Carcinogenesis.