Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

In this study, Pengelly et al. investigated the physiological role of Histone H2A monoubiquitylation (H2Aub), a key effector in transcriptional repression by PRC1. They generated Drosophila strains that lack H2Aub and found that repression of all canonical PRC1 target genes is maintained in the absence of H2Aub and that the mutant animals do not exhibit the phenotypes that are characteristic for mutants lacking Polycomb function. The findings suggest that the mechanism by which PRC1 represses gene transcription is independent of H2Aub.

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