论文信息 - MICROFLUIDIC DRIFTING: THREE DIMENSIONAL HYDRODYNAMIC FOCUSING OF MICROPARTICLES

MICROFLUIDIC DRIFTING: THREE DIMENSIONAL HYDRODYNAMIC FOCUSING OF MICROPARTICLES

In this work we present numerical simulation and experimental validation of a three-dimensional (3D) hydrodynamic microparticle focusing method based on “microfluidic drifting” technique recently developed in our group. Microfluidic drifting utilizes Dean vortical flow induced in a microfluidic curve to realize 3D hydrodynamic focusing in a single-layer planar microfluidic device. Here we show this principle can be effectively adapted to focus microparticles with size and density close to those of lymphocytes.

Xiaole Mao | Tony Jun Huang

[1] Tony Jun Huang,et al. "Microfluidic drifting"--implementing three-dimensional hydrodynamic focusing with a single-layer planar microfluidic device. , 2007, Lab on a chip.

[2] R. Tompkins,et al. Continuous inertial focusing, ordering, and separation of particles in microchannels , 2007, Proceedings of the National Academy of Sciences.