Is 17α‐hydroxyprogesterone caproate contraindicated in twin gestations?

contraindicated in twin gestations? R Romero, A Conde-Agudelo Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA Correspondence: R Romero, Perinatology Research Branch, NICHD, NIH, DHHS, 3990 John R, Box 4, Detroit, MI 48201, USA. Email: romeror@mail.nih.gov

[1]  K. Nicolaides,et al.  Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta‐analysis , 2015, BJOG : an international journal of obstetrics and gynaecology.

[2]  B. Mol,et al.  Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial , 2013, The Lancet.

[3]  R. Romero,et al.  Progesterone is not the same as 17α-hydroxyprogesterone caproate: implications for obstetrical practice. , 2013, American journal of obstetrics and gynecology.

[4]  Roberto Romero Progesterone to prevent preterm birth in twin gestations: what is the next step forward? , 2013, BJOG: an International Journal of Obstetrics and Gynaecology.

[5]  K. Nicolaides,et al.  Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. , 2012, American journal of obstetrics and gynecology.

[6]  T. Garite,et al.  Failure of 17-hydroxyprogesterone to reduce neonatal morbidity or prolong triplet pregnancy: a double-blind, randomized clinical trial. , 2010, American journal of obstetrics and gynecology.

[7]  J. Thorp,et al.  Prevention of Preterm Birth in Triplets Using 17 Alpha-Hydroxyprogesterone Caproate: A Randomized Controlled Trial , 2009, Obstetrics and gynecology.

[8]  M. Klebanoff Subgroup analysis in obstetrics clinical trials. , 2007, American journal of obstetrics and gynecology.

[9]  K. Nicolaides,et al.  Maternal characteristics and cervical length in the prediction of spontaneous early preterm delivery in twins. , 2006, American journal of obstetrics and gynecology.

[10]  B. Mol,et al.  1: Pessaries in multiple pregnancy as a prevention of preterm birth (ProTWIN): a randomized controlled trial , 2012 .