Transcriptional Control of Hepatocanalicular Transporter Gene Expression
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[1] J. Boyer,et al. Molecular pathogenesis of cholestasis. , 2012, The New England journal of medicine.
[2] R. Stravitz,et al. Regulation of mdr2 p-glycoprotein expression by bile salts and cholesterol in rats and primary cultures of rat hepatocytes. , 2000 .
[3] D. Mangelsdorf,et al. Interleukin-1β Suppresses Retinoid Transactivation of Two Hepatic Transporter Genes Involved in Bile Formation* , 2000, The Journal of Biological Chemistry.
[4] J. Lehmann,et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. , 2000, Molecular cell.
[5] P. Meier,et al. Transport function and hepatocellular localization of mrp6 in rat liver. , 2000, Molecular pharmacology.
[6] S. Khorasanizadeh,et al. Structure of the RXR–RAR DNA‐binding complex on the retinoic acid response element DR1 , 2000, The EMBO journal.
[7] D. Keppler,et al. Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. , 2000, European journal of biochemistry.
[8] H. Takikawa,et al. ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)* , 2000, The Journal of Biological Chemistry.
[9] K. Scotto,et al. Transcriptional Activation of the MDR1 Gene by UV Irradiation , 2000, The Journal of Biological Chemistry.
[10] F. Thévenod,et al. Up-regulation of Multidrug Resistance P-glycoprotein via Nuclear Factor-κB Activation Protects Kidney Proximal Tubule Cells from Cadmium- and Reactive Oxygen Species-induced Apoptosis* , 2000, The Journal of Biological Chemistry.
[11] G. Schmitz,et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[12] R. Green,et al. Molecular cloning and characterization of the murine bile salt export pump. , 2000, Gene.
[13] M. Luciani,et al. The ABCA subclass of mammalian transporters. , 1999, Biochimica et biophysica acta.
[14] D. Keppler,et al. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. , 1999, Biochimica et biophysica acta.
[15] B. Sarkadi,et al. An inventory of the human ABC proteins. , 1999, Biochimica et biophysica acta.
[16] W. Wahli,et al. Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. , 1999, Current opinion in biotechnology.
[17] H. Takano,et al. The human multidrug resistance protein 2 gene: Functional characterization of the 5′‐flanking region and expression in hepatic cells , 1999, Hepatology.
[18] D. Mangelsdorf,et al. Nuclear receptor regulation of cholesterol and bile acid metabolism. , 1999, Current opinion in biotechnology.
[19] P. Meier,et al. Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver. , 1999, Gastroenterology.
[20] A. Wolffe,et al. Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription. , 1999, Journal of molecular endocrinology.
[21] M. Karin. How NF-κB is activated: the role of the IκB kinase (IKK) complex , 1999, Oncogene.
[22] H. Pahl. Activators and target genes of Rel/NF-κB transcription factors , 1999, Oncogene.
[23] W. Wahli,et al. Steroid and nuclear receptors Villefranche‐sur‐Mer, France, May 25–27, 1999 , 1999, The EMBO journal.
[24] K. Griffin,et al. Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors. , 1999, Molecular pharmacology.
[25] O. Fardel,et al. Up‐regulation of multidrug resistance‐associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone , 1999, FEBS letters.
[26] P. Farnham,et al. Context-dependent Transcriptional Regulation* , 1999, The Journal of Biological Chemistry.
[27] V. Giguère,et al. Orphan nuclear receptors: from gene to function. , 1999 .
[28] D. Meijer,et al. Induction of hepatic mdr2 expression by cholesterol synthesis inhibitors (statins) is mediated via SERBPs , 1999 .
[29] M. Manns,et al. TNF-alpha mediated up-regulation of the multidrug resistance gene mdr1b but not of mrp1 in rat hepatocytes is dependent on NF-kappa B activation , 1999 .
[30] W. Wahli,et al. Peroxisome proliferator-activated receptors: nuclear control of metabolism. , 1999, Endocrine reviews.
[31] M. Brown,et al. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[32] Hsiu-Hsiang Lee,et al. NF‐κB‐dependent Fas ligand expression , 1999 .
[33] D. Waxman,et al. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. , 1999, Archives of biochemistry and biophysics.
[34] T. Kawamoto,et al. Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene , 1999, Molecular and Cellular Biology.
[35] G. Hooiveld,et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats. , 1999, Gastroenterology.
[36] J. Vamecq,et al. Medical significance of peroxisome proliferator-activated receptors , 1999, The Lancet.
[37] J. Boyer,et al. Molecular regulation of hepatocellular transport systems in cholestasis. , 1999, Journal of hepatology.
[38] H. Pahl. Signal transduction from the endoplasmic reticulum to the cell nucleus. , 1999, Physiological reviews.
[39] E. Zandi,et al. Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex , 1999, Molecular and Cellular Biology.
[40] Michael Karin,et al. Is NF‐κB the sensor of oxidative stress? , 1999 .
[41] P. Jansen,et al. Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats , 2018 .
[42] S. Cogoi,et al. Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin‐treated rat , 1999, Hepatology.
[43] D. Russell,et al. Nuclear Orphan Receptors Control Cholesterol Catabolism , 1999, Cell.
[44] J A Gustafsson,et al. Seeking Ligands for Lonely Orphan Receptors , 1999, Science.
[45] M. Makishima,et al. Identification of a nuclear receptor for bile acids. , 1999, Science.
[46] J. Lehmann,et al. Bile acids: natural ligands for an orphan nuclear receptor. , 1999, Science.
[47] D. Keppler,et al. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. , 1999, Molecular pharmacology.
[48] Jasmine Chen,et al. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. , 1999, Molecular cell.
[49] G. Hooiveld,et al. Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein. , 1999, Journal of cell science.
[50] M. Kavallaris,et al. Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells , 1999, Oncogene.
[51] K. Umesono,et al. A Unified Nomenclature System for the Nuclear Receptor Superfamily , 1999, Cell.
[52] D. Keppler,et al. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane , 1999, Hepatology.
[53] Paavo Honkakoski,et al. The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene* , 1999, The Journal of Biological Chemistry.
[54] L. Owen-Schaub,et al. Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment , 1999, Molecular and Cellular Biology.
[55] V. Sukhatme,et al. Sp1 and Egr-1 Have Opposing Effects on the Regulation of the RatPgp2/mdr1b Gene* , 1999, The Journal of Biological Chemistry.
[56] D. Roden,et al. Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants. , 1999, Biochimica et biophysica acta.
[57] S. Kliewer,et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[58] Q. Wang,et al. Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53. , 1998, Cancer research.
[59] G. Hooiveld,et al. Up‐regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down‐regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver , 1998, Hepatology.
[60] R. Tukey,et al. Physiological and pathophysiological regulation of cytochrome P450. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[61] T. Ishikawa,et al. Expression of Multidrug Resistance Protein/GS-X Pump and γ-Glutamylcysteine Synthetase Genes Is Regulated by Oxidative Stress* , 1998, The Journal of Biological Chemistry.
[62] S. Cole,et al. Multidrug resistance mediated by the ATP‐binding cassette transporter protein MRP , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.
[63] J. Chiang,et al. Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors. , 1998, Journal of lipid research.
[64] Richard J. Thompson,et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis , 1998, Nature Genetics.
[65] R. Evans,et al. Orphan nuclear receptors--new ligands and new possibilities. , 1998, Genes & development.
[66] W. Sabbagh,et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. , 1998, Genes & development.
[67] David D. Moore,et al. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β , 1998, Nature.
[68] T. Osborne,et al. Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein* , 1998, The Journal of Biological Chemistry.
[69] T. Sueyoshi,et al. The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene , 1998, Molecular and Cellular Biology.
[70] D. Peet,et al. The LXRs: a new class of oxysterol receptors. , 1998, Current opinion in genetics & development.
[71] J. Lehmann,et al. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. , 1998, The Journal of clinical investigation.
[72] M. Manns,et al. I. TNF-induced liver injury. , 1998, American journal of physiology. Gastrointestinal and liver physiology.
[73] Y. Sugiyama,et al. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) 1 , 1998 .
[74] Ge Zhou,et al. Wild-type p53-mediated Induction of Rat mdr1bExpression by the Anticancer Drug Daunorubicin* , 1998, The Journal of Biological Chemistry.
[75] Y. Sugiyama,et al. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. , 1998, Molecular pharmacology.
[76] R. Hammer,et al. Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.
[77] J. Boyer,et al. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. , 1998, The Journal of clinical investigation.
[78] P. Meier,et al. The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver* , 1998, The Journal of Biological Chemistry.
[79] D. Schrenk,et al. Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. , 1998, Biochemical and biophysical research communications.
[80] K. Kohno,et al. Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene* , 1998, The Journal of Biological Chemistry.
[81] T. Ishikawa,et al. Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues. , 1998, Biochemical pharmacology.
[82] J. Cidlowski,et al. Cell cycle regulation and apoptosis. , 1998, Annual review of physiology.
[83] J. Lehmann,et al. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.
[84] M L Agarwal,et al. The p53 Network* , 1998, The Journal of Biological Chemistry.
[85] D. Keppler,et al. Induction of cMrp/cMoat gene expression by cisplatin, 2‐ acetylaminofluorene, or cycloheximide in rat hepatocytes , 1997, Hepatology.
[86] E. Schuetz,et al. p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[87] D. Moore,et al. Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR* , 1997, The Journal of Biological Chemistry.
[88] D. Keppler,et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. , 1997, Gastroenterology.
[89] V. Vollrath,et al. Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver. , 1997, Journal of hepatology.
[90] Ge Zhou,et al. NF-κB-mediated Induction of mdr1b Expression by Insulin in Rat Hepatoma Cells* , 1997, The Journal of Biological Chemistry.
[91] C. White,et al. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C. , 1997, The Journal of biological chemistry.
[92] M. Müller,et al. Molecular aspects of hepatobiliary transport. , 1997, The American journal of physiology.
[93] L. O’Neill,et al. Daunorubicin Activates NFκB and Induces κB-dependent Gene Expression in HL-60 Promyelocytic and Jurkat T Lymphoma Cells* , 1997, The Journal of Biological Chemistry.
[94] J. Goldstein,et al. The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.
[95] P. Borst,et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[96] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.
[97] D. Mangelsdorf,et al. An oxysterol signalling pathway mediated by the nuclear receptor LXRα , 1996, Nature.
[98] David Baltimore,et al. NF-κB: Ten Years After , 1996, Cell.
[99] M. Tanimoto,et al. Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light. , 1996, Cancer research.
[100] J. Silverman,et al. Characterization of the rat mdr2 promoter and its regulation by the transcription factor Sp1. , 1996, Nucleic acids research.
[101] M. Müller,et al. Secretion of Organic Anions by Hepatocytes: Involvement of Homologues of the Multidrug Resistance Protein , 1996, Seminars in liver disease.
[102] M. Relling,et al. P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[103] J. Capone,et al. The Orphan Nuclear Hormone Receptor LXR Interacts with the Peroxisome Proliferator-activated Receptor and Inhibits Peroxisome Proliferator Signaling (*) , 1996, The Journal of Biological Chemistry.
[104] A. Rigotti,et al. Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse. , 1996, The Biochemical journal.
[105] Q. Zhu,et al. Evidence that SP1 modulates transcriptional activity of the multidrug resistance-associated protein gene. , 1996, DNA and cell biology.
[106] S. Cohn,et al. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. , 1996, The New England journal of medicine.
[107] P. Edwards,et al. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[108] R. Evans,et al. The RXR heterodimers and orphan receptors , 1995, Cell.
[109] A. Groen,et al. Regulation of mdr2 P-glycoprotein expression by bile salts. , 1995, The Biochemical journal.
[110] D. Meijer,et al. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. , 1995, Biochimica et biophysica acta.
[111] B. A. Hill,et al. Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter , 1995, Molecular carcinogenesis.
[112] P. Borst,et al. Characterization of the promoter region of the human MDR3 P-glycoprotein gene. , 1995, Biochimica et biophysica acta.
[113] Q. Zhu,et al. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin. , 1994, Cancer research.
[114] H. Wu,et al. NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. , 1994, The Journal of biological chemistry.
[115] J. Chiang,et al. Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter. , 1994, The Journal of biological chemistry.
[116] J. H. Beijnen,et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs , 1994, Cell.
[117] R. Costa,et al. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix , 1994, Molecular and cellular biology.
[118] D. Moore,et al. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements , 1994, Molecular and cellular biology.
[119] S. Thorgeirsson,et al. Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication , 1993, Hepatology.
[120] S. Thorgeirsson,et al. Cloning and regulation of the rat mdr2 gene. , 1993, Nucleic acids research.
[121] T. Ishikawa,et al. The ATP-dependent glutathione S-conjugate export pump. , 1992, Trends in biochemical sciences.
[122] L. Moore,et al. The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution , 2000 .
[123] J. Boyer,et al. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. , 2000, Gastroenterology.
[124] J. Chiang,et al. HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). , 2000, Journal of lipid research.
[125] G. Schroepfer,et al. Oxysterols: modulators of cholesterol metabolism and other processes. , 2000, Physiological reviews.
[126] B. O’Malley. Hormones and Signaling , 2000 .
[127] M. Relling,et al. Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. , 2000, Molecular pharmacology.
[128] R. Kim,et al. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. , 2000, Molecular pharmacology.
[129] M. Kool,et al. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. , 1999, Cancer research.
[130] M. Lutter,et al. Biochemical pathways of caspase activation during apoptosis. , 1999, Annual review of cell and developmental biology.
[131] Y. Goltsev,et al. Tumor necrosis factor receptor and Fas signaling mechanisms. , 1999, Annual review of immunology.
[132] P. Edwards,et al. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. , 1999, Annual review of biochemistry.
[133] M. Mowat,et al. p53 in tumor progression: life, death, and everything. , 1998, Advances in cancer research.
[134] D. Mangelsdorf,et al. Nuclear Orphan Receptors: The Search for Novel Ligands and Signaling Pathways , 1998 .
[135] Silverman Ja,et al. Regulation and function of the multidrug resistance genes in liver. , 1995 .
[136] I. Verma,et al. Rel/NF-kappa B/I kappa B story. , 1995, Advances in cancer research.