A study of the specific IgM antibody response in Mycoplasma pneumoniae infection in man

SUMMARY Sera from 96 patients with Mycoplasma pneumoniae infection were examined for specific IgM antibody. The complement fixation test was used to measure the IgM after separation by ultracentrifugation through sucrose density gradients. Of patients under the age of 20 years 78 % displayed positive specific IgM titres. In older patients only 34% were IgM positive. The specific IgM remained detectable, but at decreasing levels, during the follow-up period of 5 months. This diagnostic technique appears to be of value in children and young adults experiencing primary infection with M. pneumoniae.

[1]  J. Eng,et al.  The diagnostic value of determination of IgM antibodies against Mycoplasma pneumoniae by the indirect immunofluorescent antibody test. , 2009, Acta pathologica et microbiologica Scandinavica. Section B, Microbiology.

[2]  G. Biberfeld.  ANTIBODY RESPONSES IN MYCOPLASMA PNEUMONIAE INFECTION IN RELATION TO SERUM IMMUNOGLOBULINS, ESPECIALLY IgM , 2009 .

[3]  J. Suni,et al.  Serological diagnosis of Mycoplasma pneumoniae infection by enzyme immunoassay. , 1980, Journal of clinical pathology.

[4]  G. Watson.  The Treatment of Mycoplasma Pneumoniae Infections , 1977, Scottish medical journal.

[5]  E. Toma,et al.  Passive hemagglutination and complement fixation reactions in the early diagnosis of Mycoplasma pneumoniae infections. , 1976, Virologie.

[6]  T. Sato,et al.  Persistence of serum antibody following Mycoplasma pneumoniae infection. , 1970, The American review of respiratory disease.

[7]  N. Stallman,et al.  A SURVEY OF ANTIBODIES TO MYCOPLASMA PNEUMONIAE IN QUEENSLAND , 1970, The Medical journal of Australia.

[8]  J. Best,et al.  Serum IgM and IgG responses in postnatally acquired rubella. , 1969, Lancet.

[9]  L. Cordero,et al.  An aid to the rapid diagnosis of Mycoplasma pneumoniae infections. , 1969, The Journal of infectious diseases.

[10]  E. H. Lennette,et al.  On the nature of complement-fixing antibodies to Mycoplasma pneumoniae. , 1966, Journal of immunology.

[11]  Bradstreet Cm,et al.  Technique of complementfixation test applicable to the diagnosis of virus diseases. , 1962 .