Myocardial Protection Using Del Nido Cardioplegia Solution in Adult Reoperative Aortic Valve Surgery

The immediate postischemic period is marked by elevated intracellular calcium levels, which can lead to irreversible myocyte injury. Del Nido cardioplegia was developed for use in the pediatric population to address the inability of immature myocardium to tolerate high levels of intracellular calcium following cardiac surgery. Our aim in this study is to determine if this solution can be used safely and effectively in an adult, reoperative population.

[1]  R. Rose,et al.  Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts. , 2013, The Journal of thoracic and cardiovascular surgery.

[2]  P. D. del Nido,et al.  History and use of del Nido cardioplegia solution at Boston Children's Hospital. , 2012, The journal of extra-corporeal technology.

[3]  E. Bacha,et al.  Single dose myocardial protection technique utilizing del Nido cardioplegia solution during congenital heart surgery procedures , 2012, Perfusion.

[4]  S. Howlett,et al.  Protecting the aged heart during cardiac surgery: the potential benefits of del Nido cardioplegia. , 2011, The Journal of thoracic and cardiovascular surgery.

[5]  P. D. del Nido,et al.  Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery. , 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[6]  S. Howlett,et al.  Pediatric cardioplegia strategy results in enhanced calcium metabolism and lower serum troponin T. , 2009, The Annals of thoracic surgery.

[7]  J. Headrick,et al.  Age-related changes in ischemic tolerance in male and female mouse hearts. , 2005, Journal of molecular and cellular cardiology.

[8]  R. E. Clark,et al.  Cellular Protection during Myocardial Ischemia The Development and Characterization of a Procedure for the Induction of Reversible Ischemic Arrest , 2005 .

[9]  D. Hearse.  Myocardial protection during ischemia and reperfusion , 1998, Molecular and Cellular Biochemistry.

[10]  O. Cohen,et al.  Continuous retrograde cardioplegia simplifies aortic valve replacement in the presence of a patent internal mammary artery. , 2003, The Annals of thoracic surgery.

[11]  S. Agrawal,et al.  A simple technique for aortic valve replacement in patients with a patent left internal mammary artery bypass graft. , 2002, The Annals of thoracic surgery.

[12]  T. Mihaljevic,et al.  Aortic valve surgery after previous coronary artery bypass grafting with functioning internal mammary artery grafts. , 2002, The Annals of thoracic surgery.

[13]  D. Garcia-Dorado,et al.  Prime causes of rapid cardiomyocyte death during reperfusion. , 1999, The Annals of thoracic surgery.

[14]  T. Ruigrok,et al.  The role of the Na+ channel in the accumulation of intracellular Na+ during myocardial ischemia: consequences for post-ischemic recovery. , 1997, Journal of molecular and cellular cardiology.