Immunoglobulin class and pattern of nuclear fluorescence in systemic lupus erythematosus.

THE presence of antibodies that react with nuclei in the serums of patients with systemic lupus erythematosus is well established. Human antibodies have been found to belong to 1 of 3 classes of immunoglobulins that can be distinguished from each other by antigenic differences in the heavy polypeptide chains. These are the IgG, the IgA and the IgM globulins. The immunoglobulin class to which the antinuclear factor belongs has previously been investigated in small numbers of patients. Goodman and Fahey1 first demonstrated the presence of both IgG and IgM antinuclear factors, and recent work by Barnett and his co-workers2 and . . .

[1]  J. Uhr,et al.  THE HETEROGENEITY OF THE IMMUNE RESPONSE. , 1964, Science.

[2]  J. Leddy,et al.  GAMMA-2, GAMMA-1A AND GAMMA-1M ANTINUCLEAR FACTORS IN HUMAN SERA. , 1964, The Journal of clinical investigation.

[3]  G. Friou,et al.  SIGNIFICANCE OF ANTIBODY TO DNA IN SYSTEMIC LUPUS ERYTHEMATOSUS. , 1964, Arthritis and rheumatism.

[4]  G. Friou,et al.  SPECIFIC NUCLEAR REACTION PATTERN OF ANTIBODY TO DNA IN LUPUS ERYTHEMATOSUS SERA. , 1963, The Journal of laboratory and clinical medicine.

[5]  C. Fink,et al.  The formation of macroglobulin antibodies. I. Studies on adult humans. , 1962, The Journal of clinical investigation.

[6]  N. Rothfield,et al.  Relation of positive L.E.-cell preparations to activity of lupus erythematosus and corticosteroid therapy. , 1962, The New England journal of medicine.

[7]  E. Franklin,et al.  Studies of mercaptoethanol-dissociated normal human 19 S gamma-globulin and pathologic macroglobulins from patients with macroglobulinemia. , 1961, Journal of immunology.

[8]  Beck Js.  Variations in the morphological patterns of "autoimmune" nuclear fluorescence. , 1961 .

[9]  J. Fahey,et al.  Serum factors in lupus erythematosus and other diseases reacting with cell nuclei and nucleoprotein extracts: electrophoretic. ultracentrifugal and chromatographic studies. , 1960, The Journal of clinical investigation.

[10]  C. Plotz,et al.  The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. , 1956, The American journal of medicine.

[11]  B. Frangione,et al.  SLOWLY SEDIMENTING MERCAPTOETHANOL-RESISTANT ANTINUCLEAR FACTORS RELATED ANTIGENICALLY TO M IMMUNOGLOBULINS (GAMMA-1M-GLOBULIN) IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. , 1965, The Journal of clinical investigation.

[12]  S. Svehag,et al.  THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION. , 1964 .