Fabrication of novel core–shell PLGA and alginate fiber for dual‐drug delivery system

Biodegradable fibers for the controlled delivery of anti-inflammatory agent dexamethasone were developed and studied. Mono and core–shell structure fiber are prepared by wet-spinning solutions of hydrophobic poly (lactide-co-glycolide) and hydrophilic alginic acid shell. The two model drugs, dexamethasone and dexamethasone-21-phosphate, were entrapped in core and shell, respectively. These fibers were characterized in terms of morphology, diameters, mechanical properties, in vitro degradation, and drug release. The optical microscopy and scanning electron microscopy photos revealed directly that fibers possessed core–shell structure. The release of dexamethasone and dexamethasone-21-phosphate was investigated, and the results showed that alginate shell retarded dexamethasone release significantly in both early and late stages. The core–shell structure fiber release shows a two stage release of dexamethasone and dexamethasone-21-phosphate with distinctly different release rates, and minimal initial burst release is observed. The results indicated that the prepared fibers are efficient carrier for both types of dexamethasone. Copyright © 2016 John Wiley & Sons, Ltd.

[1]  Yueqing Gu,et al.  The implantable 5-fluorouracil-loaded poly(l-lactic acid) fibers prepared by wet-spinning from suspension. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[2]  J. M. Mazzara,et al.  Healing kinetics of microneedle-formed pores in PLGA films. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[3]  Yimin Qin,et al.  Alginate fibres: an overview of the production processes and applications in wound management , 2008 .

[4]  Y. Tabata,et al.  Biodegradable scleral plugs for vitreoretinal drug delivery. , 2001, Advanced drug delivery reviews.

[5]  E. Morris,et al.  Biological interactions between polysaccharides and divalent cations: The egg‐box model , 1973 .

[6]  Meital Zilberman,et al.  Mechanical properties and in vitro degradation of bioresorbable fibers and expandable fiber-based stents. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[7]  G. Smith,et al.  Evaluation of in vitro drug release, pH change, and molecular weight degradation of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) fibers. , 2005, Tissue engineering.

[8]  M. Yoshida,et al.  In vitro release and characterization of chitosan films as dexamethasone carrier. , 2009, International journal of pharmaceutics.

[9]  Rohit Srivastava,et al.  Stable encapsulation of active enzyme by application of multilayer nanofilm coatings to alginate microspheres. , 2005, Macromolecular bioscience.

[10]  Y. Ogura,et al.  Biodegradable Polymers for Ocular Drug Delivery , 2001, Ophthalmologica.

[11]  David C. Martin,et al.  Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. , 2006, Biomaterials.

[12]  V. Labhasetwar,et al.  Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles. , 2004, Molecular pharmaceutics.

[13]  R. A. Jain,et al.  The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. , 2000, Biomaterials.

[14]  J. Gong,et al.  Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[15]  Shaobing Zhou,et al.  Controlled delivery of paracetamol and protein at different stages from core–shell biodegradable microspheres , 2010 .

[16]  David C. Martin,et al.  Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices. , 2004, Journal of biomedical materials research. Part A.

[17]  Yimin Qin.  The gel swelling properties of alginate fibers and their applications in wound management , 2008 .

[18]  Mansoor Amiji,et al.  Enzyme immobilization in novel alginate-chitosan core-shell microcapsules. , 2004, Biomaterials.

[19]  H. Klok,et al.  Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. , 2001, Advanced drug delivery reviews.

[20]  L. Sagis,et al.  Preparation methods of alginate nanoparticles. , 2014, Advances in colloid and interface science.

[21]  K. Nelson,et al.  Technique paper for wet-spinning poly(L-lactic acid) and poly(DL-lactide-co-glycolide) monofilament fibers. , 2003, Tissue engineering.

[22]  J. Hilborn,et al.  Constructs of electrospun PLGA, compressed collagen and minced urothelium for minimally manipulated autologous bladder tissue expansion. , 2014, Biomaterials.

[23]  Chi‐Hwa Wang,et al.  PEG modulated release of etanidazole from implantable PLGA/PDLA discs. , 2002, Biomaterials.

[24]  R. Gurny,et al.  Intraocular implants for extended drug delivery: therapeutic applications. , 2006, Advanced drug delivery reviews.

[25]  F. Quignard,et al.  Influence of both cation and alginate nature on the rheological behavior of transition metal alginate gels. , 2014, Carbohydrate polymers.

[26]  K. Nelson,et al.  Release of bovine serum albumin from a hydrogel‐cored biodegradable polymer fiber , 2006, Biopolymers.

[27]  Mark E. Davis,et al.  A biodegradable filament for controlled drug delivery. , 2009, Journal of controlled release : official journal of the Controlled Release Society.