Hypoxia Inducible Factors (HIF1α and HIF3α) are differentially methylated in preeclampsia placentae and are associated with birth outcomes

[1]  Biwei He,et al.  Autophagy Activation by Hypoxia Regulates Angiogenesis and Apoptosis in Oxidized Low-Density Lipoprotein-Induced Preeclampsia , 2021, Frontiers in Molecular Biosciences.

[2]  V. Phupong,et al.  Serum hypoxia-inducible factor-1α and uterine artery Doppler ultrasound during the first trimester for prediction of preeclampsia , 2021, Scientific Reports.

[3]  G. Chandak,et al.  Placental growth factor and Fms related tyrosine kinase-1 are hypomethylated in preeclampsia placentae. , 2021, Epigenomics.

[4]  Y. Wang,et al.  MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway. , 2021, Physiological research.

[5]  Hongmei Qu,et al.  HIF-3α affects preeclampsia development by regulating EVT growth via activation of the Flt-1/JAK/STAT signaling pathway in hypoxia , 2020, Molecular medicine reports.

[6]  A. Pezic,et al.  HIF3A cord blood methylation and systolic blood pressure at 4 years – a population-based cohort study , 2020, Epigenetics.

[7]  Yingying Li,et al.  HIF-1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions , 2020, Molecular medicine reports.

[8]  Y. Hu,et al.  The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism , 2020, Frontiers in Endocrinology.

[9]  M. Handel,et al.  Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard , 2020, Science Advances.

[10]  T. Naicker,et al.  Oligodendrocytes Death Induced Sensorimotor and Cognitive Deficit in N-nitro-l-arginine methyl Rat Model of Pre-eclampsia , 2020, Neurochemical Research.

[11]  A. Veiga-Lopez,et al.  Gestational exposure to bisphenol A and bisphenol S leads to fetal skeletal muscle hypertrophy independent of sex. , 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[12]  I. Adam,et al.  Placental growth factor, vascular endothelial growth factor, and hypoxia-inducible factor-1α in the placentas of women with pre-eclampsia , 2019, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[13]  J. Mose,et al.  The Difference in Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Preeclampsia , 2019, Open access Macedonian journal of medical sciences.

[14]  A. Ponsonby,et al.  Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study , 2019, Clinical Epigenetics.

[15]  D. Natale,et al.  Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction , 2019, Scientific Reports.

[16]  M. Lan,et al.  Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance , 2018, Journal of Translational Medicine.

[17]  F. Fahlbusch,et al.  Expression and Regulation of Retinoic Acid Receptor Responders in the Human Placenta , 2018, Reproductive Sciences.

[18]  S. Salimi,et al.  The association of the placental Hypoxia-inducible factor1-α polymorphisms and HIF1-α mRNA expression with preeclampsia. , 2018, Placenta.

[19]  S. Salahuddin,et al.  Relationship between hypoxia and downstream pathogenic pathways in preeclampsia , 2017, Hypertension in pregnancy.

[20]  B. Mol,et al.  Preeclampsia; short and long-term consequences for mother and neonate. , 2016, Early human development.

[21]  M. Fasshauer,et al.  Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction , 2016, Scientific Reports.

[22]  Nigel P. Dyer,et al.  Loss of Endometrial Plasticity in Recurrent Pregnancy Loss , 2016, Stem cells.

[23]  Jun Ma,et al.  HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT , 2015, PloS one.

[24]  M. Ferrari,et al.  HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia: a longitudinal prospective study in high risk population , 2015, Clinical chemistry and laboratory medicine.

[25]  Alexander M. Morin,et al.  HIF3A association with adiposity: the story begins before birth , 2015, Epigenomics.

[26]  S. Joshi,et al.  A longitudinal study of circulating angiogenic and antiangiogenic factors and AT1-AA levels in preeclampsia , 2014, Hypertension Research.

[27]  Y. Zhong,et al.  Maternal obesity is associated with a lipotoxic placental environment. , 2014, Placenta.

[28]  E. Clementi,et al.  Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia. , 2014, American journal of physiology. Endocrinology and metabolism.

[29]  M. Asaka,et al.  Hypoxia-Inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors , 2013, PloS one.

[30]  A. Hardikar,et al.  Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia , 2013, Clinical Epigenetics.

[31]  R. Tal.  The Role of Hypoxia and Hypoxia-Inducible Factor-1Alpha in Preeclampsia Pathogenesis , 2012, Biology of reproduction.

[32]  M. Siatecka,et al.  The multifunctional role of EKLF/KLF1 during erythropoiesis. , 2011, Blood.

[33]  R. Mortimer,et al.  Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development. , 2010, Placenta.

[34]  M. Post,et al.  Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies , 2010, PloS one.

[35]  K. Kivirikko,et al.  Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2. , 2010, The international journal of biochemistry & cell biology.

[36]  S. Joshi,et al.  Circulating angiogenic factors and their association with birth outcomes in preeclampsia , 2010, Hypertension Research.

[37]  W. Aird,et al.  Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. , 2010, Blood.

[38]  G. Rice,et al.  Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia. , 2010, Placenta.

[39]  Chia-Ming Chang,et al.  MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells , 2010, Journal of cellular and molecular medicine.

[40]  J. Corbeil,et al.  The transcription factor Egr1 regulates the HIF‐1α gene during hypoxia , 2009, Molecular carcinogenesis.

[41]  A. Jeyabalan,et al.  Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. , 2008, Placenta.

[42]  A. Luca,et al.  Distribution of Notch protein members in normal and preeclampsia-complicated placentas , 2007, Cell and Tissue Research.

[43]  L. Poellinger,et al.  Hypoxia Inducible Factor-2α in Cancer , 2007, Cell cycle.

[44]  M. Jewett,et al.  Human HIF‐3α4 is a dominant‐negative regulator of HIF‐1 and is down‐regulated in renal cell carcinoma , 2005 .

[45]  Yasufumi Sato,et al.  Metallothionein 1 is a downstream target of vascular endothelial zinc finger 1 (VEZF1) in endothelial cells and participates in the regulation of angiogenesis. , 2005, Endothelium : journal of endothelial cell research.

[46]  E. Jauniaux,et al.  The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus--a review. , 2003, Placenta.

[47]  B. Westerman,et al.  The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion , 2002, Mechanisms of Development.

[48]  S. Artavanis-Tsakonas,et al.  Notch Signaling : Cell Fate Control and Signal Integration in Development , 1999 .

[49]  Li Zhang 张 莉,et al.  Expression of lung surfactant proteins SP-B and SP-C and their modulating factors in fetal lung of FGR rats , 2015, Journal of Huazhong University of Science and Technology [Medical Sciences].

[50]  J. Blangero,et al.  A transcriptional profile of the decidua in preeclampsia. , 2011, American journal of obstetrics and gynecology.

[51]  J. Dastych,et al.  DNA methylation-dependent suppression of HIF1A in an immature hematopoietic cell line HMC-1. , 2010, Biochemical and biophysical research communications.

[52]  J. McMillan,et al.  GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions. , 2004, Blood cells, molecules & diseases.