The value of EEG‐fMRI and EEG source analysis in the presurgical setup of children with refractory focal epilepsy

Purpose:  In the presurgical evaluation of children and juvenile patients with refractory focal epilepsy, the main challenge is to localize the point of seizure onset as precisely as possible. We compared results of the conventional electroencephalography–functional magnetic resonance imaging (EEG‐fMRI) analysis with those obtained with a newly developed method using voltage maps of average interictal epileptiform discharges (IEDs) recorded during clinical long‐term monitoring and with the results of the electric source imaging (ESI).

[1]  U. Stephani,et al.  Improving sensitivity of EEG–fMRI studies in epilepsy: The role of sleep-specific activity , 2011, Neuroscience Letters.

[2]  Christoph M. Michel,et al.  Localization of cortico-peripheral coherence with electroencephalography , 2011, NeuroImage.

[3]  L. Lemieux,et al.  With or without spikes: localization of focal epileptic activity by simultaneous electroencephalography and functional magnetic resonance imaging. , 2011, Brain : a journal of neurology.

[4]  Christoph M. Michel,et al.  Spatiotemporal Analysis of Multichannel EEG: CARTOOL , 2011, Comput. Intell. Neurosci..

[5]  D. Ville,et al.  BOLD correlates of EEG topography reveal rapid resting-state network dynamics , 2010, NeuroImage.

[6]  M. Walker,et al.  EEG correlated functional MRI and postoperative outcome in focal epilepsy , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[7]  Claudio Pollo,et al.  Electrical source imaging for presurgical focus localization in epilepsy patients with normal MRI , 2010, Epilepsia.

[8]  J. Daunizeau,et al.  The combination of EEG Source Imaging and EEG‐correlated functional MRI to map epileptic networks , 2010, Epilepsia.

[9]  Christoph M. Michel,et al.  Continuous EEG source imaging enhances analysis of EEG-fMRI in focal epilepsy , 2010, NeuroImage.

[10]  F. Dubeau,et al.  Understanding the epileptogenicity of lesions: A correlation between intracranial EEG and EEG/fMRI , 2010, Epilepsia.

[11]  Christoph M. Michel,et al.  Combination of EEG–fMRI and EEG source analysis improves interpretation of spike-associated activation networks in paediatric pharmacoresistant focal epilepsies , 2009, NeuroImage.

[12]  Christoph M. Michel,et al.  The spatio-temporal mapping of epileptic networks: Combination of EEG–fMRI and EEG source imaging , 2009, NeuroImage.

[13]  C. Michel,et al.  Accuracy of EEG source imaging of epileptic spikes in patients with large brain lesions , 2009, Clinical Neurophysiology.

[14]  Stephan Wolff,et al.  Non-REM sleep influences results of fMRI studies in epilepsy , 2008, Neuroscience Letters.

[15]  J. Gotman,et al.  Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG‐fMRI , 2008, Epilepsia.

[16]  Jean Gotman,et al.  Variability of the hemodynamic response as a function of age and frequency of epileptic discharge in children with epilepsy , 2008, NeuroImage.

[17]  Denis Brunet,et al.  Topographic ERP Analyses: A Step-by-Step Tutorial Review , 2008, Brain Topography.

[18]  Jean Gotman,et al.  Concordance between distributed EEG source localization and simultaneous EEG-fMRI studies of epileptic spikes , 2008, NeuroImage.

[19]  Jean Gotman,et al.  Hemodynamic Responses to Interictal Epileptiform Discharges in Children with Symptomatic Epilepsy , 2007, Epilepsia.

[20]  Stephan Wolff,et al.  Spatial filters and automated spike detection based on brain topographies improve sensitivity of EEG–fMRI studies in focal epilepsy , 2007, NeuroImage.

[21]  F. Leijten,et al.  EEG-fMRI in the preoperative work-up for epilepsy surgery. , 2007, Brain : a journal of neurology.

[22]  A. Leal,et al.  Brain Mapping of Epileptic Activity in a Case of Idiopathic Occipital Lobe Epilepsy (Panayiotopoulos Syndrome) , 2007, Epilepsia.

[23]  K. Krakow,et al.  FMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood: A simultaneous EEG-functional MRI study , 2007, Clinical Neurophysiology.

[24]  M. Scherg,et al.  Combined spike-related functional MRI and multiple source analysis in the non-invasive spike localization of benign rolandic epilepsy , 2007, Clinical Neurophysiology.

[25]  Alan Connelly,et al.  EEG‐fMRI in Children with Pharmacoresistant Focal Epilepsy , 2007, Epilepsia.

[26]  A. Kleinschmidt,et al.  Temporal lobe interictal epileptic discharges affect cerebral activity in “default mode” brain regions , 2006, Human brain mapping.

[27]  Jean Gotman,et al.  EEG‐fMRI using z‐shimming in patients with temporal lobe epilepsy , 2006, Journal of magnetic resonance imaging : JMRI.

[28]  Alberto Leal,et al.  The BOLD Effect of Interictal Spike Activity in Childhood Occipital Lobe Epilepsy , 2006, Epilepsia.

[29]  C. Michel,et al.  EEG Source Imaging in Pediatric Epilepsy Surgery: A New Perspective in Presurgical Workup , 2006, Epilepsia.

[30]  Jean Gotman,et al.  Negative BOLD responses to epileptic spikes , 2006, Human brain mapping.

[31]  J. Gotman,et al.  Combining EEG and fMRI: A multimodal tool for epilepsy research , 2006, Journal of magnetic resonance imaging : JMRI.

[32]  Karl J. Friston,et al.  Hemodynamic correlates of epileptiform discharges: An EEG-fMRI study of 63 patients with focal epilepsy , 2006, Brain Research.

[33]  Jean Gotman,et al.  EEG–fMRI of epileptic spikes: Concordance with EEG source localization and intracranial EEG , 2006, NeuroImage.

[34]  J. Gotman,et al.  Temporal and Extratemporal BOLD Responses to Temporal Lobe Interictal Spikes , 2006, Epilepsia.

[35]  J. Gotman,et al.  Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. , 2006, Brain : a journal of neurology.

[36]  J. Gotman,et al.  Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikes , 2006, Clinical Neurophysiology.

[37]  David F Abbott,et al.  Cortical/subcortical BOLD changes associated with epileptic discharges , 2005, Neurology.

[38]  M. Murray,et al.  EEG source imaging , 2004, Clinical Neurophysiology.

[39]  Jean Gotman,et al.  EEG‐fMRI of focal epileptic spikes: Analysis with multiple haemodynamic functions and comparison with gadolinium‐enhanced MR angiograms , 2004, Human brain mapping.

[40]  M. Scherg,et al.  EEG and MEG Source Analysis of Single and Averaged Interictal Spikes Reveals Intrinsic Epileptogenicity in Focal Cortical Dysplasia , 2004, Epilepsia.

[41]  J. Gotman,et al.  fMRI Activation in Continuous and Spike‐triggered EEG–fMRI Studies of Epileptic Spikes , 2003, Epilepsia.

[42]  Peter Stoeter,et al.  EEG‐related Functional MRI in Benign Childhood Epilepsy with Centrotemporal Spikes , 2003, Epilepsia.

[43]  Christoph M. Michel,et al.  Epileptic source localization with high density EEG: how many electrodes are needed? , 2003, Clinical Neurophysiology.

[44]  Patrick Berg,et al.  Advanced Tools for Digital EEG Review:: Virtual Source Montages, Whole-head Mapping, Correlation, and Phase Analysis , 2002, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[45]  H. Lüders,et al.  Presurgical evaluation of epilepsy. , 2001, Brain : a journal of neurology.

[46]  Jerome Engel,et al.  A Proposed Diagnostic Scheme for People with Epileptic Seizures and with Epilepsy: Report of the ILAE Task Force on Classification and Terminology , 2001, Epilepsia.

[47]  Robert Turner,et al.  A Method for Removing Imaging Artifact from Continuous EEG Recorded during Functional MRI , 2000, NeuroImage.

[48]  P Berg,et al.  Multiple source analysis of interictal spikes: goals, requirements, and clinical value. , 1999, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[49]  J. Haueisen,et al.  Influence of tissue resistivities on neuromagnetic fields and electric potentials studied with a finite element model of the head , 1997, IEEE Transactions on Biomedical Engineering.

[50]  O. Henriksen,et al.  Does a sedative dose of chloral hydrate modify the EEG of children with epilepsy? , 1997, Electroencephalography and clinical neurophysiology.

[51]  R. Mattson,et al.  Comparison of bitemporal and unitemporal epilepsy defined by depth electroencephalography , 1991, Annals of neurology.

[52]  F. Perrin,et al.  Spherical splines for scalp potential and current density mapping. , 1989, Electroencephalography and clinical neurophysiology.

[53]  J. Kröll-Seger Epilepsien im Kindes- und Jugendalter , 2011 .

[54]  L. Lemieux,et al.  Neuronal networks in children with continuous spikes and waves during slow sleep. , 2010, Brain : a journal of neurology.

[55]  P M Rossini,et al.  Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? , 2004, Brain : a journal of neurology.

[56]  C. Michel,et al.  Electromagnetic Inverse Solutions in Anatomically Constrained Spherical Head Models , 2004, Brain Topography.

[57]  Louis Lemieux,et al.  Role of functional magnetic resonance imaging in the evaluation of patients with malformations caused by cortical development. , 2002, Neurosurgery clinics of North America.

[58]  Paolo Inchingolo,et al.  Accuracy of EEG source reconstruction in the presence of brain lesions: modelling errors and surface electrodes' placement. , 2002, Biomedical sciences instrumentation.

[59]  J. Siegel,et al.  Chloral hydrate anesthesia: EEG power spectrum analysis and effects on VEPs in the rat. , 1989, Neurotoxicology and teratology.

[60]  F. Perrin,et al.  Mapping of scalp potentials by surface spline interpolation. , 1987, Electroencephalography and clinical neurophysiology.