Integrative epigenetic analysis reveals AP-1 promotes activation of tumor-infiltrating regulatory T cells in HCC

[1]  E. Wherry,et al.  Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. , 2022, Immunity.

[2]  Jun‐liang Fu,et al.  Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B. , 2021, Journal of hepatology.

[3]  M. Mokry,et al.  Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation , 2021, Nature Communications.

[4]  G. Feng,et al.  Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies , 2020, Hepatology.

[5]  Haihe Ruan,et al.  Analysis of Local Chromatin States Reveals Gene Transcription Potential during Mouse Neural Progenitor Cell Differentiation. , 2020, Cell reports.

[6]  Y. Okada,et al.  Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases. , 2020, Immunity.

[7]  C. Peano,et al.  IRF4 instructs effector Treg differentiation and immune suppression in human cancer. , 2020, The Journal of clinical investigation.

[8]  M. Looso,et al.  Beyond accessibility: ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation , 2019, bioRxiv.

[9]  S. Ha,et al.  Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function , 2019, Journal of Immunotherapy for Cancer.

[10]  M. Weirauch,et al.  AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation , 2019, The Journal of experimental medicine.

[11]  Howard Y. Chang,et al.  Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion , 2019, Nature Biotechnology.

[12]  Hatice S. Kaya-Okur,et al.  CUT&Tag for efficient epigenomic profiling of small samples and single cells , 2019, Nature Communications.

[13]  S. Sakaguchi,et al.  Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer. , 2019, Immunity.

[14]  H. Nishikawa,et al.  Regulatory T cells in cancer immunosuppression — implications for anticancer therapy , 2019, Nature Reviews Clinical Oncology.

[15]  Sandy L. Klemm,et al.  Chromatin accessibility and the regulatory epigenome , 2019, Nature Reviews Genetics.

[16]  Sanja Stevanović,et al.  Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity , 2019, Science Immunology.

[17]  E. Newell,et al.  Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody , 2018, Proceedings of the National Academy of Sciences.

[18]  R. Weissleder,et al.  Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types , 2018, Proceedings of the National Academy of Sciences.

[19]  Yuri Pritykin,et al.  Epigenetic control of innate and adaptive immune memory , 2018, Nature Immunology.

[20]  Ambrose J. Carr,et al.  Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment , 2018, Cell.

[21]  T. Pugh,et al.  Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma , 2018, Clinical Cancer Research.

[22]  Boxi Kang,et al.  Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing , 2018, Nature Medicine.

[23]  Marcel H. Schulz,et al.  Identification of transcription factor binding sites using ATAC-seq , 2018, bioRxiv.

[24]  Angela E. Leek,et al.  Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies , 2018, Cancer cell.

[25]  S. Sakaguchi,et al.  Molecular control of regulatory T cell development and function. , 2017, Current opinion in immunology.

[26]  Xue-qing Xu,et al.  Quantitative analysis of chromatin accessibility in mouse embryonic fibroblasts. , 2017, Biochemical and biophysical research communications.

[27]  Boxi Kang,et al.  Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing , 2017, Cell.

[28]  S. Sakaguchi,et al.  Regulatory T cells in cancer immunotherapy , 2016, Cell Research.

[29]  G. Plitas,et al.  Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. , 2016, Immunity.

[30]  H. Stunnenberg,et al.  Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells , 2016, Immunity.

[31]  J. Kawai,et al.  The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. , 2014, Blood.

[32]  Howard Y. Chang,et al.  Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position , 2013, Nature Methods.

[33]  J. Wolchok,et al.  Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma , 2013, The Journal of experimental medicine.

[34]  S. Sakaguchi,et al.  Development and maintenance of regulatory T cells. , 2013, Immunity.

[35]  J. Dekker,et al.  The hierarchy of the 3D genome. , 2013, Molecular cell.

[36]  A. Rudensky,et al.  Control of inflammation by integration of environmental cues by regulatory T cells. , 2013, The Journal of clinical investigation.

[37]  Shane J. Neph,et al.  Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification , 2012, Cell.

[38]  A. Rudensky,et al.  Regulatory T cells: mechanisms of differentiation and function. , 2012, Annual review of immunology.

[39]  A. Liston,et al.  Regulatory T Cells , 2011, Methods in Molecular Biology.

[40]  R. Young,et al.  Histone H3K27ac separates active from poised enhancers and predicts developmental state , 2010, Proceedings of the National Academy of Sciences.

[41]  L. Olson,et al.  The Ets-1 transcription factor controls the development and function of natural regulatory T cells , 2010, The Journal of experimental medicine.

[42]  R. Baumgrass,et al.  Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells , 2010, Journal of Molecular Medicine.

[43]  W. Paul,et al.  Differentiation of effector CD4 T cell populations (*). , 2010, Annual review of immunology.

[44]  Nathaniel D. Heintzman,et al.  Histone modifications at human enhancers reflect global cell-type-specific gene expression , 2009, Nature.

[45]  Yuka Kanno,et al.  Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. , 2009, Immunity.

[46]  T. Nomura,et al.  CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.

[47]  S. Hirono,et al.  Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1 , 2008, Nature Biotechnology.

[48]  D. Vignali,et al.  How regulatory T cells work , 2008, Nature Reviews Immunology.

[49]  Yoshinobu Sato,et al.  Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. , 2006, Journal of hepatology.

[50]  M. Karin,et al.  AP-1 as a regulator of cell life and death , 2002, Nature Cell Biology.

[51]  A. Fisher,et al.  Chromatin structure and gene regulation in the immune system. , 2002, Annual review of immunology.

[52]  J. Shimizu,et al.  Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. , 1999, Journal of immunology.

[53]  T. Fujita,et al.  Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. , 1999, Cancer research.

[54]  D. Woodfield.  Hepatocellular carcinoma. , 1986, The New Zealand medical journal.

[55]  D. Galas,et al.  DNAse footprinting: a simple method for the detection of protein-DNA binding specificity. , 1978, Nucleic acids research.