Quantification of vocal tract configuration of older children with Down syndrome: a pilot study.

OBJECTIVE To quantify the vocal tract (VT) lumen of older children with Down syndrome using acoustic reflection (AR) technology. DESIGN Comparative study. SETTING Vocal tract lab with sound-proof booth. PARTICIPANTS Ten children (4 males and 6 females), aged 9-17 years old diagnosed with Down syndrome. Ten typically developing children (4 males and 6 females) matched for age, gender, and race. INTERVENTION Each participant's vocal tract measurements were obtained by using an Eccovision Acoustic Pharyngometer. MAIN OUTCOME MEASURES Six vocal tract dimensional parameters (oral length, oral volume, pharyngeal length, pharyngeal volume, total vocal tract length, and total vocal tract volume) from children with Down syndrome and the typically developing children were measured and compared. RESULTS Children with Down syndrome exhibited small oral cavities when compared to control group (F(1,18)=6.55, p=0.02). They also demonstrated a smaller vocal tract volumes (F(1,18)=2.58, p=0.13), although the results were not statistically significant at the 0.05 level. Pharyngeal length, pharyngeal volume, and vocal tract length were not significantly different between the two groups. CONCLUSION Children with Down syndrome had smaller oral cavities, and smaller vocal tract volumes. No significant differences were found for pharyngeal length, pharyngeal volume, and vocal tract length between these two groups.

[1]  J. M. Fouke,et al.  Reproducibility of measurements of upper airway area by acoustic reflection. , 1989, Journal of applied physiology.

[2]  W. Fitch Vocal tract length and formant frequency dispersion correlate with body size in rhesus macaques. , 1997, The Journal of the Acoustical Society of America.

[3]  N. Roizen,et al.  Down's syndrome , 2003, The Lancet.

[4]  A L Pentz,et al.  Formant amplitude of children with Down syndrome. , 1987, American journal of mental deficiency.

[5]  J. Fredberg,et al.  Pulmonary airway area by the two-microphone acoustic reflection method. , 1994, Journal of applied physiology.

[6]  T. Iacono,et al.  Effect of tongue reduction on articulation in children with Down syndrome. , 1987, American journal of mental deficiency.

[7]  J. Best,et al.  Acoustic reflectometry for airway measurements in man: implementation and validation , 1993, Physiological measurement.

[8]  J. Fredberg,et al.  Airway area by acoustic reflections measured at the mouth. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[9]  Robin S. Chapman,et al.  Language development in children and adolescents with Down syndrome , 1997 .

[10]  N. Zamel,et al.  Pharyngeal cross-sectional area in normal men and women. , 1986, Journal of applied physiology.

[11]  L. Kumin Intelligibility of Speech in Children with down Syndrome in Natural Settings: Parents' Perspective , 1994, Perceptual and motor skills.

[12]  M. Wexler,et al.  [Facial plastic surgery in Down's syndrome]. , 1984, Harefuah.

[13]  L. Farkas,et al.  Surface Anatomy of the Face in Down's Syndrome: Linear and Angular Measurements in the Craniofacial Regions , 2001, The Journal of craniofacial surgery.

[14]  I. Munro,et al.  Changes in Aesthetic Appearance and Intelligibility of Speech After Partial Glossectomy in Patients with Down Syndrome , 1988, Plastic and reconstructive surgery.

[15]  G. Laws,et al.  Contributions of phonological memory, language comprehension and hearing to the expressive language of adolescents and young adults with Down syndrome. , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[16]  Arthur S Slutsky,et al.  Airway area by acoustic response measurements and computerized tomography. , 1987, The American review of respiratory disease.

[17]  S. Xue,et al.  Volumetric measurements of vocal tracts for male speakers from different races , 2006, Clinical linguistics & phonetics.

[18]  J. Sideris,et al.  A comparison of oral structure and oral-motor function in young males with fragile X syndrome and Down syndrome. , 2006, Journal of speech, language, and hearing research : JSLHR.

[19]  F. H. Kemp,et al.  Tongue size in Down's syndrome. , 2008, Journal of mental deficiency research.

[20]  G. Lemperle,et al.  Facial plastic surgery in children with Down's syndrome. , 1980, Plastic and reconstructive surgery.

[21]  R S Chapman,et al.  Behavioral phenotype of individuals with Down syndrome. , 2000, Mental retardation and developmental disabilities research reviews.

[22]  S. Reilly,et al.  AN EXPLORATION OF FEEDING DIFFICULTIES IN CHILDREN WITH DOWN SYNDROME , 1996, Developmental medicine and child neurology.

[23]  A C Bryan,et al.  Upper airway morphology in patients with idiopathic obstructive sleep apnea. , 2015, The American review of respiratory disease.

[24]  C. Stoel-Gammon Down syndrome. Effects on language development. , 1990, ASHA.

[25]  D. Bless,et al.  Communication Profiles of Adolescents With Down Syndrome , 1988 .

[26]  B. Shapiro Amplified developmental instability in Down's syndrome , 1975, Annals of human genetics.

[27]  G. Annéren,et al.  Epidemiology of birthweight , 2002, Archives of disease in childhood.

[28]  S. Morris,et al.  Pre-feeding skills , 2000 .

[29]  C. McGrother,et al.  Recent trends in incidence, morbidity and survival in Down's syndrome. , 2008, Journal of mental deficiency research.

[30]  L. Farkas,et al.  Age-Related Changes in Anthropometric Measurements in the Craniofacial Regions and in Height in Down's Syndrome , 2002, The Journal of craniofacial surgery.

[31]  K. Mizuno,et al.  Development of sucking behavior in infants with Down's syndrome , 2001, Acta paediatrica.

[32]  Steve An Xue,et al.  Changes in the human vocal tract due to aging and the acoustic correlates of speech production: a pilot study. , 2003, Journal of speech, language, and hearing research : JSLHR.

[33]  D. Bishop,et al.  Language development in exceptional circumstances , 1988 .

[34]  I. Munro,et al.  Speech intelligibility after partial glossectomy in children with Down's syndrome. , 1987, Plastic and reconstructive surgery.

[35]  Jack J. Jiang,et al.  Age-related changes in human vocal tract configurations and the effects on speakers' vowel formant frequencies: A pilot study , 1999 .

[36]  Robert H. Nelson,et al.  A Comparison of the Nasal Cross-Sectional Areas and Volumes Obtained with Acoustic Rhinometry and Magnetic Resonance Imaging , 1997, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[37]  N. Zamel,et al.  Pharyngeal size in snorers, nonsnorers, and patients with obstructive sleep apnea. , 1986, The New England journal of medicine.

[38]  N. Gavriely,et al.  Acoustic Reflectometry and Endotracheal Intubation , 1996, Anesthesia and analgesia.

[39]  K. Williams,et al.  Correlates of specific childhood feeding problems , 2003, Journal of paediatrics and child health.

[40]  S. Buckley Improving the expressive language skills of teenagers with Down syndrome , 1995 .

[41]  J. Dang,et al.  Morphological and acoustical analysis of the nasal and the paranasal cavities. , 1994, The Journal of the Acoustical Society of America.

[42]  I. Kamal,et al.  Normal standard curve for acoustic pharyngometry. , 2001, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[43]  A. Pack,et al.  Magnetic resonance imaging of the upper airway in children with Down syndrome. , 2001, American journal of respiratory and critical care medicine.

[44]  A. Panchón-Ruíz,et al.  Palate vault morphology in Down syndrome. , 2000, Journal of craniofacial genetics and developmental biology.

[45]  L. Wolf,et al.  Feeding and Swallowing Disorders in Infancy: Assessment and Management , 1991 .

[46]  M. Cohen,et al.  Variations of Palatal Dimensions in Patients with Down's Syndrome , 1975, Journal of dental research.

[47]  Libby Kumin,et al.  Speech and language skills in children with Down syndrome , 1996 .

[48]  D. Glavina,et al.  Palatal and dental arch morphology in Down syndrome. , 2004, Collegium antropologicum.

[49]  L. Farkas,et al.  Surface Anatomy of the Face in Down's Syndrome: Anthropometric Proportion Indices in the Craniofacial Regions , 2001, The Journal of craniofacial surgery.

[50]  W. Tecumseh,et al.  Vocal Tract Length Perception and the Evolution of Language , 1994 .