Flow chemistry syntheses of natural products.
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[1] Steven V Ley,et al. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor. , 2010, Organic & biomolecular chemistry.
[2] Yuta Murai,et al. Highly (Z)-Selective Synthesis of β-Monosubstituted α,β-Unsaturated Cyanides Using the Peterson Reaction , 2004 .
[3] The changing face of organic synthesis , 2010 .
[4] L. Marion,et al. The structure of sedamine. , 1951, Canadian journal of chemistry.
[5] Steven V Ley,et al. Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent. , 2011, Organic & biomolecular chemistry.
[6] J. Yoshida,et al. Grignard Exchange Reaction Using a Microflow System: From Bench to Pilot Plant , 2005 .
[7] Steven V Ley,et al. A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles. , 2011, Organic & biomolecular chemistry.
[8] Hayato Yoshida,et al. Continuous-flow synthesis of vitamin D3. , 2010, Chemical communications.
[9] P. Scheuer,et al. Hennoxazoles, bioactive bisoxazoles from a marine sponge , 1991 .
[10] Steven V. Ley,et al. A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing† , 2011 .
[11] Jun-ichi Yoshida,et al. Green and sustainable chemical synthesis using flow microreactors. , 2011, ChemSusChem.
[12] N. Zhu,et al. Syntheses of dihydroartemisinic acid and dihydro-epi-deoxyarteannuin B incorporating a stable isotope label at the 15-position for studies into the biosynthesis of artemisinin , 2001 .
[13] Richard J Ingham,et al. Camera-enabled techniques for organic synthesis , 2013, Beilstein journal of organic chemistry.
[14] Markus Hager,et al. Application of metal-based reagents and catalysts in microstructured flow devices. , 2012, ChemSusChem.
[15] S. Ley,et al. A modular flow reactor for performing Curtius rearrangements as a continuous flow process. , 2008, Organic & biomolecular chemistry.
[16] Pedro Fernandes,et al. Microfluidic Devices: Useful Tools for Bioprocess Intensification , 2011, Molecules.
[17] Jeremy L. Steinbacher,et al. Greener approaches to organic synthesis using microreactor technology. , 2007, Chemical reviews.
[18] Peter Gilligan,et al. A bacterial cell to cell signal in the lungs of cystic fibrosis patients. , 2002, FEMS microbiology letters.
[19] J. F. Stevens,et al. Alkaloids of some Asian Sedum species , 1996 .
[20] Steven V Ley,et al. Continuous flow reaction monitoring using an on-line miniature mass spectrometer. , 2012, Rapid communications in mass spectrometry : RCM.
[21] D. Spring,et al. Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule , 2010, Journal of bacteriology.
[22] Geoffrey D. Brown,et al. The mechanism of the spontaneous autoxidation of dihydroartemisinic acid , 2002 .
[23] T. Bieringer,et al. Future Production Concepts in the Chemical Industry: Modular – Small‐Scale – Continuous , 2013 .
[24] Steven V. Ley,et al. Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas-liquid contact. , 2010, Organic letters.
[25] Steven V Ley,et al. The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow: using Teflon AF-2400 to effect gas/liquid contact. , 2012, ChemSusChem.
[26] Bernd Nidetzky,et al. Biotransformations in microstructured reactors: more than flowing with the stream? , 2011, Trends in biotechnology.
[27] David M J S Bowman,et al. Flammable biomes dominated by eucalypts originated at the Cretaceous-Palaeogene boundary. , 2011, Nature communications.
[28] Steven V. Ley,et al. Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents , 1999 .
[29] Claudio Battilocchio,et al. A prototype device for evaporation in batch and flow chemical processes , 2013 .
[30] Steven V Ley,et al. Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates. , 2009, Organic & biomolecular chemistry.
[31] S. Achanta,et al. The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques. , 2010, Chemistry.
[32] Steven V Ley,et al. A prototype continuous-flow liquid-liquid extraction system using open-source technology. , 2012, Organic & biomolecular chemistry.
[33] T. Yasumoto,et al. Isolation and structure of yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning , 1987 .
[34] S. Ley,et al. Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration. , 2011, Organic & biomolecular chemistry.
[35] R. Bouillon,et al. Structure-function relationships in the vitamin D endocrine system. , 1995, Endocrine reviews.
[36] M. Köck,et al. Siphonazole, an unusual metabolite from Herpetosiphon sp. , 2006, Angewandte Chemie.
[37] Robert Ashe,et al. Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor , 2011 .
[38] Tetsuro Ito,et al. Three new resveratrol oligomers from the stem bark of Vatica pauciflora. , 2004, Journal of natural products.
[39] John Tsanaktsidis,et al. Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids , 2010 .
[40] R. Sarpong,et al. Concise synthesis of pauciflorol F using a Larock annulation. , 2009, Organic letters.
[41] Steven V. Ley,et al. Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor , 2010 .
[42] Steven V Ley,et al. KMnO(4)-Mediated oxidation as a continuous flow process. , 2010, Organic letters.
[43] Koichi Fukase,et al. Renaissance of Traditional Organic Reactions under Microfluidic Conditions: A New Paradigm for Natural Products Synthesis , 2009 .
[44] Steven V Ley,et al. A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures. , 2011, Organic letters.
[45] Jun-ichi Yoshida,et al. Flash chemistry: fast chemical synthesis by using microreactors. , 2008, Chemistry.
[46] K. Jensen,et al. Multistep continuous-flow microchemical synthesis involving multiple reactions and separations. , 2007, Angewandte Chemie.
[47] Steven V. Ley,et al. ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing , 2010 .
[48] S. Ley,et al. Polymer supported perruthenate (PSP): a new oxidant for clean organic synthesis , 1997 .
[49] M.H.J.M. de Croon,et al. Novel process windows – Concept, proposition and evaluation methodology, and intensified superheated processing , 2011 .
[50] C. Oliver Kappe,et al. Continuous-flow syntheses of heterocycles , 2011 .
[51] Ryan L. Hartman,et al. Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis. , 2011, Angewandte Chemie.
[52] M. Iwu,et al. Convulsant alkaloids from Dioscorea dumetorum , 1985 .
[53] Steven V. Ley,et al. Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation , 2000 .
[54] T. Yoshihara,et al. A new lignan amide, grossamide, from bell pepper (Capsicum annuum var. grossum) , 1981 .
[55] Andreas Kirschning,et al. Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts. , 2006, Chemistry.
[56] Steven V. Ley,et al. Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas-liquid contact at elevated pressure†‡ , 2011 .
[57] Shū Kobayashi,et al. Asymmetric carbon-carbon bond formation under continuous-flow conditions with chiral heterogeneous catalysts. , 2013, Angewandte Chemie.
[58] Daiki Sakai,et al. Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly. , 2011, Chemistry.
[59] S. Ley,et al. Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low-Temperature Flow Processes , 2013 .
[60] Ian R. Baxendale,et al. The integration of flow reactors into synthetic organic chemistry , 2013 .
[61] Steven V Ley,et al. Microwave reactions under continuous flow conditions. , 2007, Combinatorial chemistry & high throughput screening.
[62] N. White,et al. Qinghaosu (Artemisinin): The Price of Success , 2008, Science.
[63] Timothy F. Jamison,et al. Continuous flow multi-step organic synthesis , 2010 .
[64] Steven V Ley,et al. Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration. , 2012, Organic & biomolecular chemistry.
[65] Yunqing Lin,et al. Total synthesis of diverse carbogenic complexity within the resveratrol class from a common building block. , 2009, Journal of the American Chemical Society.
[66] Steven V Ley,et al. Continuous multiple liquid-liquid separation: diazotization of amino acids in flow. , 2012, Organic letters.
[67] Simon Saubern,et al. A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin. , 2010, Chemistry.
[68] Peter H Seeberger,et al. Continuous-flow synthesis of the anti-malaria drug artemisinin. , 2012, Angewandte Chemie.
[69] Steven V. Ley,et al. Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes , 2013 .
[70] Katsunori Tanaka,et al. Synthesis of a sialic acid containing complex-type N-glycan on a solid support. , 2009, Chemistry, an Asian journal.
[71] T. Wirth,et al. Flow chemistry: enabling technology in drug discovery and process research. , 2012, ChemSusChem.
[72] Shin-ichi Tanaka,et al. Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step. , 2007, Organic letters.
[73] Andreas Seidel-Morgenstern,et al. Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography. , 2012, Angewandte Chemie.
[74] D. Passarella,et al. Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies. , 2011, Chemistry.
[75] Katsunori Tanaka,et al. Reinvestigation of the C5-acetamide sialic acid donor for α-selective sialylation: practical procedure under microfluidic conditions. , 2011, Organic & biomolecular chemistry.
[76] S. Diggle,et al. Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species. , 2008, Molecular bioSystems.
[77] Peter H Seeberger,et al. Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century? , 2006, Chemistry.
[78] Steven V Ley,et al. On being green: can flow chemistry help? , 2012, Chemical record.
[79] Christian H. Hornung,et al. A Microcapillary Flow Disc Reactor for Organic Synthesis , 2007 .
[80] Steven V. Ley,et al. The flow synthesis of heterocycles for natural product and medicinal chemistry applications , 2011, Molecular Diversity.
[81] J. Wegner,et al. Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis , 2012 .
[82] Neal G. Anderson,et al. Using Continuous Processes to Increase Production , 2012 .
[83] Steven V Ley,et al. The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor. , 2011, Angewandte Chemie.
[84] S. Ley,et al. A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. , 2006, Chemical communications.
[85] I. Karle,et al. Histrionicotoxins: roentgen-ray analysis of the novel allenic and acetylenie spiroalkaloids isolated from a Colombian frog, Dendrobates histrionicus. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[86] Steven V Ley,et al. Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions. , 2008, Organic & biomolecular chemistry.
[87] Andreas Kirschning,et al. Ten key issues in modern flow chemistry. , 2011, Chemical communications.
[88] H. Koeffler,et al. The role of the vitamin D endocrine system in health and disease. , 1989, The New England journal of medicine.
[89] T. Oishi. Convergent Method via α-Cyano Ethers: A Powerful Strategy for Synthesizing Ladder-Shaped Polyethers , 2012 .
[90] Steven V Ley,et al. A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist. , 2010, Chemistry.
[91] Steven V. Ley,et al. Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor , 2012 .
[92] A. Carroll,et al. Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp. , 2008, Journal of natural products.
[93] D. Spring,et al. Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues. , 2011, Organic & biomolecular chemistry.
[94] R. Haynes,et al. A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides , 1998 .
[95] Steven V. Ley,et al. New tools and concepts for modern organic synthesis , 2002, Nature Reviews Drug Discovery.
[96] Geoffrey D. Brown,et al. The role of the 12-carboxylic acid group in the spontaneous autoxidation of dihydroartemisinic acid , 2002 .
[97] Steven V Ley,et al. Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor. , 2011, Organic letters.
[98] Steven V Ley,et al. A flow-based synthesis of imatinib: the API of Gleevec. , 2010, Chemical communications.
[99] Paul Watts,et al. Recent advances in micro reaction technology. , 2011, Chemical communications.
[100] Steven V Ley,et al. An expeditious synthesis of imatinib and analogues utilising flow chemistry methods. , 2013, Organic & biomolecular chemistry.
[101] E. Greenberg,et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[102] Steven V Ley,et al. The application of flow microreactors to the preparation of a family of casein kinase I inhibitors. , 2010, Organic & biomolecular chemistry.
[103] C. Wiles,et al. Continuous flow reactors: a perspective , 2012 .
[104] Gary S. Calabrese,et al. From batch to continuous flow processing in chemicals manufacturing , 2011 .
[105] C. Codina,et al. Crinane and lycorane type alkaloids from Zephyranthes citrina. , 2001, Planta medica.
[106] S. Snyder,et al. Total synthesis of resveratrol-based natural products: a chemoselective solution. , 2007, Angewandte Chemie.
[107] Ryan L. Hartman. Managing Solids in Microreactors for the Upstream Continuous Processing of Fine Chemicals , 2012 .
[108] J. Yoshida. Flash chemistry using electrochemical method and microsystems. , 2005, Chemical communications.
[109] W. Okamura,et al. Synthesis of Vitamin D (Calciferol) , 1995 .
[110] Volker Hessel,et al. A View Through Novel Process Windows , 2013 .
[111] Jun-ichi Yoshida,et al. Flash chemistry: flow microreactor synthesis based on high-resolution reaction time control. , 2010, Chemical record.