Protein phosphorylation in signaling--50 years and counting.

[1]  Charles Kung,et al.  Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Xiang-Jiao Yang,et al.  Multisite protein modification and intramolecular signaling , 2005, Oncogene.

[3]  C. Sawyers,et al.  Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Robert T Sauer,et al.  Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[5]  John D. Scott,et al.  AKAP signalling complexes: focal points in space and time , 2004, Nature Reviews Molecular Cell Biology.

[6]  R. Lefkowitz.  Historical review: a brief history and personal retrospective of seven-transmembrane receptors. , 2004, Trends in pharmacological sciences.

[7]  Tony Pawson,et al.  Specificity in Signal Transduction From Phosphotyrosine-SH2 Domain Interactions to Complex Cellular Systems , 2004, Cell.

[8]  C. Pickart.  Back to the Future with Ubiquitin , 2004, Cell.

[9]  Pier Paolo Di Fiore,et al.  Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation , 2003, Nature Cell Biology.

[10]  G. Superti-Furga,et al.  Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase , 2003, Cell.

[11]  P. Cohen,et al.  A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. , 2001, Molecular Cell.

[12]  C. Sawyers,et al.  Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. , 2001, The New England journal of medicine.

[13]  M. Yaffe,et al.  PhosphoSerine/threonine binding domains: you can't pSERious? , 2001, Structure.

[14]  Alexander Varshavsky,et al.  The ubiquitin system. , 1998, Annual review of biochemistry.

[15]  Wolfgang Baumeister,et al.  The Proteasome: Paradigm of a Self-Compartmentalizing Protease , 1998, Cell.

[16]  S. Hubbard.  Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog , 1997, The EMBO journal.

[17]  C. Moorehead.  All rights reserved , 1997 .

[18]  K. Shokat,et al.  Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[19]  P. Allen,et al.  Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine , 1996, Cell.

[20]  A. Gilman.  Nobel Lecture. G proteins and regulation of adenylyl cyclase. , 1995, Bioscience reports.

[21]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[22]  E. Krebs.  Protein phosphorylation and cellular regulation I , 1993 .

[23]  E. Krebs.  Nobel Lecture. Protein phosphorylation and cellular regulation I. , 1993, Bioscience reports.

[24]  A. Levitzki,et al.  Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins. , 1992, The Journal of biological chemistry.

[25]  J. Tobias,et al.  The N-end rule in bacteria. , 1991, Science.

[26]  A. Varshavsky,et al.  The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A. Murray,et al.  Cyclin is degraded by the ubiquitin pathway , 1991, Nature.

[28]  A. Varshavsky,et al.  The recognition component of the N‐end rule pathway. , 1990, The EMBO journal.

[29]  Alexander Varshavsky,et al.  In vivo degradation of a transcriptional regulator: The yeast α2 repressor , 1990, Cell.

[30]  Susan S. Taylor,et al.  cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. , 1990, Annual review of biochemistry.

[31]  A. Gilman.  G proteins and regulation of adenylyl cyclase , 1989 .

[32]  L. Johnson,et al.  The allosteric transition of glycogen phosphorylase , 1989, Nature.

[33]  Alexander Varshavsky,et al.  The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis , 1989, Nature.

[34]  D. Ecker,et al.  A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. , 1989, Science.

[35]  A. Varshavsky,et al.  The degradation signal in a short-lived protein , 1989, Cell.

[36]  M. Goebl,et al.  The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. , 1988, Science.

[37]  Alexander Varshavsky,et al.  The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme , 1987, Nature.

[38]  A. Varshavsky,et al.  The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses , 1987, Cell.

[39]  T Pawson,et al.  A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps , 1986, Molecular and cellular biology.

[40]  Susan M. Watanabe,et al.  An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity , 1984, Cell.

[41]  A. Ciechanover,et al.  Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85 , 1984, Cell.

[42]  A. Ciechanover,et al.  Components of Ubiquitin-Protein Ligase System , 1983 .

[43]  A Ciechanover,et al.  Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[44]  T. Hunter,et al.  An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates , 1979, Cell.

[45]  A. Hershko,et al.  A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. , 1978, Biochemical and biophysical research communications.

[46]  E. Krebs,et al.  An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle. , 1968, The Journal of biological chemistry.

[47]  E. Sutherland,et al.  Formation of a cyclic adenine ribonucleotide by tissue particles. , 1958, The Journal of biological chemistry.

[48]  E. Krebs,et al.  Conversion of phosphorylase b to phosphorylase a in muscle extracts. , 1955, The Journal of biological chemistry.

[49]  E. P. Kennedy,et al.  The enzymatic phosphorylation of proteins. , 1954, The Journal of biological chemistry.

[50]  P. Levene,et al.  SERINEPHOSPHORIC ACID OBTAINED ON HYDROLYSIS OF VITELLINIC ACID , 1932 .

[51]  P. Levene,et al.  THE CLEAVAGE PRODUCTS OF VITELLIN , 1906 .