Prosthetic valve endocarditis by Trichosporon mucoides

Abstract Nationale: Trichosporon species are widely distributed in nature and are emerging opportunistic human pathogens. Trichosporon infections are associated with superficial cutaneous involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. Until now, there is no report in infective endocarditis by Trichosporon mucoides confirmed by molecular diagnostics Patient concerns: A 66-year-old man presented with a fever that had occurred for a period of 6 months. He had undergone aortic valve replacement 10 years prior. Transthoracic echocardiography showed vegetations on the prosthetic aortic valve and native mitral valve. T mucoides was detected in the cultures of blood and vegetations. Diagnosis: DNA sequencing using D/D2 region of rRNA and internal transcribed spacer were performed. Interventions: Infections were successfully controlled with valve replacement and voriconazole plus liposomal amphotericin B therapy. Outcomes: There has been no sign of recurrence for 18-months after treatment completion. Lessons: This is the first reported case of infective endocarditis due to T mucoides. Clinicians should consider Trichosporon species as causative agents of endocarditis in patients who have undergone cardiac surgery.