Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis

Dear Editor Japanese opticospinal multiple sclerosis (OSMS) has significant differences to MS in Caucasians.1,2 Lesions are confined to the optic nerve and spinal cord with minor brainstem lesions, no clinical evidence of cerebellar or cerebral involvement, and at least one relapse. Recent studies have shown antibodies targeting myelin oligodendrocyte glycoprotein (MOG) in patients with simultaneous bilateral and recurrent optic neuritis (ON).3,4 We hypothesized that some patients with OSMS may be positive for MOG antibodies.