p-Adic Structure of the Genetic Code

The genetic code is connection between 64 codons, which are building blocks of the genes, and 20 amino acids, which are building blocks of the proteins. In addition to coding amino acids, a few codons code stop signal, which is at the end of genes, i.e. it terminates process of protein synthesis. This article is a review of simple modelling of the genetic code and related subjects by concept of p-adic distance. It also contains some new results. In particular, the article presents appropriate structure of the codon space, degeneration and possible evolution of the genetic code. p-Adic modelling of the genetic code is viewed as the first step in further application of p-adic tools in the information sector of life science.

[1]  S. Osawa,et al.  Recent evidence for evolution of the genetic code , 1992, Microbiological reviews.

[2]  P. Freund,et al.  p-adic numbers in physics , 1993 .

[3]  M. Forger,et al.  Lie superalgebras and the multiplet structure of the genetic code. I. Codon representations , 2000 .

[4]  Branko Dragovich,et al.  p-Adic Modelling of the Genome and the Genetic Code , 2007, Comput. J..

[5]  Grace Jordison Molecular Biology of the Gene , 1965, The Yale Journal of Biology and Medicine.

[6]  Iu B Rumer [Systematization of codons in the genetic code]. , 1968, Doklady Akademii nauk SSSR.

[7]  Jayanth R Banavar,et al.  Physics of proteins. , 2007, Annual review of biophysics and biomolecular structure.

[8]  Fernando Q. Gouvêa,et al.  P-Adic Numbers: An Introduction , 1993 .

[9]  Brian Hayes,et al.  THE INVENTION OF THE GENETIC CODE , 1998 .

[10]  G. Toulouse,et al.  Ultrametricity for physicists , 1986 .

[11]  S. V. Kozyrev,et al.  Genetic code on the diadic plane , 2007, q-bio/0701007.

[12]  V. I. Shcherbak,et al.  Arithmetic inside the universal genetic code. , 2003, Bio Systems.

[13]  S. V. Kozyrev,et al.  On p-adic mathematical physics , 2006, 0904.4205.

[14]  T. Négadi The genetic code multiplet structure, in one number , 2007, 0707.2011.

[15]  J. Wong A co-evolution theory of the genetic code. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Branko Dragovich,et al.  p-Adic Degeneracy of the Genetic Code , 2007, ArXiv.

[17]  F. H. C. CRICK,et al.  Origin of the Genetic Code , 1967, Nature.

[18]  M. Rakocevic,et al.  A harmonic structure of the genetic code. , 2004, Journal of theoretical biology.

[19]  Branko Dragovich,et al.  Genetic Code and Number Theory , 2009, 0911.4014.

[20]  L. Frappat,et al.  Crystalizing the Genetic Code , 2000, Journal of biological physics.

[21]  Laura F. Landweber,et al.  Rewiring the keyboard: evolvability of the genetic code , 2001, Nature Reviews Genetics.

[22]  Branko Dragovich,et al.  p-Adic and Adelic Quantum Mechanics , 2003, hep-th/0312046.

[23]  R. Swanson A unifying concept for the amino acid code. , 1984, Bulletin of mathematical biology.

[24]  Hornos Algebraic model for the evolution of the genetic code. , 1993, Physical review letters.

[25]  Rumer IuB Systematization of codons in the genetic code , 1969 .

[26]  V A Avetisov,et al.  p-adic models of ultrametric diffusion constrained by hierarchical energy landscapes , 2002 .

[27]  Branko Dragovich,et al.  A p-adic model of DNA sequence and genetic code , 2006, ArXiv.

[28]  A. Khrennikov Information Dynamics in Cognitive, Psychological, Social, and Anomalous Phenomena , 2004 .

[29]  Peter D. Jarvis,et al.  Codon and nucleotide assignments in a supersymmetric model of the genetic code , 1997 .

[30]  Edward N. Trifonov,et al.  The Triplet Code From First Principles , 2004, Journal of biomolecular structure & dynamics.

[31]  B. Dragovich p‐Adic and Adelic Cosmology: p‐Adic Origin of Dark Energy and Dark Matter , 2006, hep-th/0602044.