The Role of Oxidative Stress in Children with Acute and Chronic Immune Thrombocytopenic Purpura

Primary immune thrombocytopenia, previously referred to as idiopathic thrombocytopenic purpura (ITP) is an immune-mediated acquired disorder characterized by mucocutaneous bleeding and isolated thrombocytopenia below 100,000/uL in the absence of any specific cause of the thrombocytopenia [1]. It is further classified according to its duration since diagnosis as follows; newly diagnosed (<3 months), persistent (3-12 months) and chronic (>12 months) [2]. Platelets coated with antibodies are phagocytized by macrophages homing in the reticuloendothelial Abstract

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