Kaempferol ameliorates pulmonary vascular remodeling in chronic hypoxia-induced pulmonary hypertension rats via regulating Akt-GSK3β-cyclin axis.
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D. Lu | Shanshan Su | Xingmei Nan | Zhanqiang Li | Zhanting Yang | Xiaonan Zhang | Xin Xie
[1] M. Humbert,et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. , 2022, European heart journal.
[2] J. Lorenzo,et al. Kaempferol: A flavonoid with wider biological activities and its applications , 2022, Critical reviews in food science and nutrition.
[3] B. Cockrill,et al. Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review. , 2022, JAMA.
[4] Yongzhen Lu,et al. A narrative review of research advances in hypoxic pulmonary hypertension , 2022, Annals of translational medicine.
[5] Hong Yu,et al. Integrated metabolomics and mechanism to reveal the protective effect of kaempferol on pulmonary arterial hypertension. , 2022, Journal of pharmaceutical and biomedical analysis.
[6] F. Léon-Velarde,et al. High-altitude erythrocytosis: mechanisms of adaptive and mal-adaptive responses. , 2022, Physiology.
[7] Xin Zhao,et al. Antioxidant and Inflammatory Effects of Nelumbo nucifera Gaertn. Leaves , 2021, Oxidative medicine and cellular longevity.
[8] H. Ditzel,et al. Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer , 2021, Nature Communications.
[9] P. Siques,et al. Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure , 2021, Frontiers in Physiology.
[10] Lianyu Chen,et al. Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling , 2021, BMC Cancer.
[11] Wenkai Yang,et al. Kaempferol Alleviates Oxidative Stress and Apoptosis Through Mitochondria-dependent Pathway During Lung Ischemia-Reperfusion Injury , 2021, Frontiers in Pharmacology.
[12] M. Rahmani,et al. Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives , 2021, Cancers.
[13] J. Zhai,et al. Kaempferol suppresses proliferation and induces apoptosis and DNA damage in human gallbladder cancer cells through the CDK4/CDK6/cyclin D1 pathway. , 2021, European Review for Medical and Pharmacological Sciences.
[14] H. Ghofrani,et al. Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders , 2021, International journal of environmental research and public health.
[15] Y. Qi,et al. Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[16] Rakesh Kundu,et al. Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells. , 2020, Archives of biochemistry and biophysics.
[17] G. Dianov,et al. A unified model for the G1/S cell cycle transition , 2020, Nucleic acids research.
[18] Wei Gao,et al. Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway. , 2020, Biochemical and biophysical research communications.
[19] Yan Jiang,et al. Sodium Tanshinone II Sulfonate A Ameliorates Hypoxia-Induced Pulmonary Hypertension , 2020, Frontiers in Pharmacology.
[20] Z. Bai,et al. High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. , 2020, Life sciences.
[21] J. Y. Lee,et al. Biventricular diastolic dysfunction, thrombocytopenia, and red blood cell macrocytosis in experimental pulmonary arterial hypertension , 2020, Pulmonary circulation.
[22] W. El-Deiry,et al. Targeting apoptosis in cancer therapy , 2020, Nature Reviews Clinical Oncology.
[23] R. Rafikov,et al. Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension , 2020, Antioxidants.
[24] Jing Shi,et al. Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway. , 2020, Chemico-biological interactions.
[25] Wenkai Yang,et al. Kaempferol Improves Lung Ischemia-Reperfusion Injury via Antiinflammation and Antioxidative Stress Regulated by SIRT1/HMGB1/NF-κB Axis , 2020, Frontiers in Pharmacology.
[26] Rili Ge,et al. Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas axis in rat. , 2019, Journal of ethnopharmacology.
[27] L. Lv,et al. Omethoate induces pharyngeal cancer cell proliferation and G1/S cell cycle progression by activation of Akt/GSK-3β/cyclin D1 signaling pathway. , 2019, Toxicology.
[28] Gang Fang,et al. The mechanism of anticancer action and potential clinical use of kaempferol in the treatment of breast cancer. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[29] M. Kamal,et al. Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy. , 2019, Seminars in cancer biology.
[30] G. Ji,et al. Recent progress regarding kaempferol for the treatment of various diseases , 2019, Experimental and therapeutic medicine.
[31] Kok-Gan Chan,et al. Formononetin: A Review of Its Anticancer Potentials and Mechanisms , 2019, Front. Pharmacol..
[32] Lijun Xue,et al. Kaempferol Suppresses Proliferation and Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Breast Cancer Cells. , 2019, Oncology research.
[33] B. Salehi,et al. Kaempferol: A Key Emphasis to Its Anticancer Potential , 2019, Molecules.
[34] C. Ruppert,et al. Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension , 2019, Nature Communications.
[35] A. Rauf,et al. Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review , 2018, Phytotherapy research : PTR.
[36] R. Roskoski. Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs. , 2019, Pharmacological research.
[37] Rili Ge,et al. Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells , 2018, BioMed research international.
[38] Jiwang Chen,et al. Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway , 2018, Nature Communications.
[39] Dinesh Kumar,et al. Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery , 2018, Pharmacological reports : PR.
[40] Liangxing Wang,et al. Adenosine A(2A) receptor activation reverses hypoxia‑induced rat pulmonary artery smooth muscle cell proliferation via cyclic AMP‑mediated inhibition of the SDF1‑CXC4 signaling pathway. , 2018, International Journal of Molecular Medicine.
[41] Rili Ge,et al. Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats. , 2018, Journal of ethnopharmacology.
[42] Guogang Zhang,et al. Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration , 2018, Cardiovascular research.
[43] R. Mancinelli,et al. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases , 2017, Oxidative medicine and cellular longevity.
[44] Lu Gao,et al. Kaempferol Alleviates Angiotensin II-Induced Cardiac Dysfunction and Interstitial Fibrosis in Mice , 2017, Cellular Physiology and Biochemistry.
[45] Liangxing Wang,et al. Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling , 2017, Journal of Biomedical Science.
[46] W. Seeger,et al. Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs. , 2017, American journal of respiratory and critical care medicine.
[47] Xianguang Fan,et al. Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. , 2016, Oncology reports.
[48] R. Malhotra,et al. Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats. , 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[49] Yun Liu,et al. Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways. , 2016, The international journal of biochemistry & cell biology.
[50] G. Shapiro,et al. Targeting CDK4 and CDK6: From Discovery to Therapy. , 2016, Cancer discovery.
[51] R. Brandes,et al. Molecular mechanisms of hypoxia‐inducible factor‐induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension , 2016, The Journal of physiology.
[52] Xia Fang,et al. Mitofusin 2 Downregulation Triggers Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis Imbalance in Rats With Hypoxic Pulmonary Hypertension Via the PI3K/Akt and Mitochondrial Apoptosis Pathways , 2016, Journal of cardiovascular pharmacology.
[53] L. Pan,et al. Research on rat models of hypobaric hypoxia-induced pulmonary hypertension. , 2015, European review for medical and pharmacological sciences.
[54] H. Ghofrani,et al. Pathophysiology and Treatment of High-Altitude Pulmonary Vascular Disease , 2015, Circulation.
[55] J. Garcia,et al. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. , 2015, American journal of physiology. Lung cellular and molecular physiology.
[56] P. Eshtehardi,et al. Thrombocytopenia is an independent predictor of mortality in pulmonary hypertension. , 2014, Heart & lung : the journal of critical care.
[57] J. Reusch,et al. Inhibition of Phosphatidylinositol 3-kinase/Akt Signaling Attenuates Hypoxia-induced Pulmonary Artery Remodeling and Suppresses CREB Depletion in Arterial Smooth Muscle Cells , 2013, Journal of cardiovascular pharmacology.
[58] Yong-ping Su,et al. ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation , 2013, Cell Death and Disease.
[59] Rainald Fischer,et al. Hypobaric Hypoxia Causes Body Weight Reduction in Obese Subjects , 2010, Obesity.
[60] R. Douglas,et al. Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development , 2008, Pediatric pulmonology.
[61] E. Walters,et al. Phosphodiesterase 5 inhibitors for pulmonary hypertension , 2004 .
[62] E. Papoutsakis,et al. Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes , 2000, British journal of haematology.