The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta‐analysis of studies from recent decade (2008‐2018)

The incidence of bilateral breast cancer (BBC) is increasing nowadays comprising 2%‐11% of all breast cancer (BC). According to the interval time between the first and second cancer, BBC could be divided into synchronous (SBBC) and metachronous (MBBC). However, this interval time is quite different across studies. It remains controversial whether the survival of BBC, SBBC, and MBBC is similar or worse compared to that of unilateral breast cancer (UBC), and whether the survival of SBBC is similar or worse compared to MBBC. To better understand the survival of UBC, BBC, SBBC, and MBBC and how the interval time would influence the prognosis of SBBC and MBBC, we performed this meta‐analysis on studies from recent 10 years (2008‐2018).

[1]  G. Alço,et al.  Synchronous and metachronous bilateral breast cancer: A long-term experience. , 2018, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[2]  B. Tan,et al.  Bilateral breast cancers in an Asian population, and a comparison between synchronous and metachronous tumours , 2018, ANZ journal of surgery.

[3]  Fenggang Yang,et al.  Northeast China 东北地区 , 2018, Atlas of Religion in China: Social and Geographical Contexts.

[4]  V. Seshan,et al.  Contralateral breast cancers: Independent cancers or metastases? , 2018, International journal of cancer.

[5]  R. Sarin,et al.  Bilateral Breast Cancer After Multimodality Treatment: A Report of Clinical Outcomes in an Asian Population , 2017, Clinical breast cancer.

[6]  A. Schneeweiss,et al.  pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials. , 2017, Breast.

[7]  F. Fostira,et al.  Disease evolution and heterogeneity in bilateral breast cancer. , 2016, American journal of cancer research.

[8]  L. Cai,et al.  Survival analysis of patients with unilateral and bilateral primary breast cancer in Northeast China , 2015, Breast Cancer.

[9]  H. Struikmans,et al.  Bilateral breast cancer, synchronous and metachronous; differences and outcome , 2015, Breast Cancer Research and Treatment.

[10]  M. Morrow,et al.  Breast-Conserving Surgery in Bilateral Breast Cancer , 2015, Annals of Surgical Oncology.

[11]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[12]  A. Tjønneland,et al.  Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies , 2014, Breast Cancer Research and Treatment.

[13]  S. Narod.  Bilateral breast cancers , 2014, Nature Reviews Clinical Oncology.

[14]  Wenwen Geng,et al.  The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients , 2013, Tumor Biology.

[15]  J. Coebergh,et al.  Increased risks of third primary cancers of non-breast origin among women with bilateral breast cancer , 2012, British Journal of Cancer.

[16]  R. Kreienberg,et al.  Survival of patients with bilateral versus unilateral breast cancer and impact of guideline adherent adjuvant treatment: a multi-centre cohort study of 5292 patients. , 2012, Breast.

[17]  B. Munárriz,et al.  Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience , 2012, Medical Oncology.

[18]  Y. Miki,et al.  High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas , 2012, Breast Cancer Research and Treatment.

[19]  X. An,et al.  Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer , 2012, Journal of Cancer Research and Clinical Oncology.

[20]  M. Lesperance,et al.  A case-match study comparing unilateral with synchronous bilateral breast cancer outcomes. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  U. Güth,et al.  Prognosis of early-stage synchronous bilateral invasive breast cancer. , 2011, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[22]  O. Olopade,et al.  Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers , 2011, British Journal of Cancer.

[23]  D. Roder,et al.  Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. , 2011, Breast.

[24]  Nicola Miller,et al.  Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics , 2011, Breast Cancer Research and Treatment.

[25]  J. L. Uriburu,et al.  Bilateral Breast Carcinoma: Clinical Characteristics and Its Impact on Survival , 2010, The breast journal.

[26]  U. Bick,et al.  Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[27]  T. Wiggers,et al.  The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer. , 2009, European journal of cancer.

[28]  King-Jen Chang,et al.  Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women , 2009, British Journal of Cancer.

[29]  R. Pommier,et al.  Incidence and outcomes of contralateral breast cancers. , 2008, American journal of surgery.

[30]  G. Vlastos,et al.  Survival after bilateral breast cancer: results from a population-based study , 2007, Breast Cancer Research and Treatment.

[31]  K. Czene,et al.  Incidence and prognosis of synchronous and metachronous bilateral breast cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[32]  M. Sydes,et al.  Practical methods for incorporating summary time-to-event data into meta-analysis , 2007, Trials.

[33]  E. Imyanitov,et al.  Molecular pathogenesis of bilateral breast cancer. , 2003, Cancer letters.

[34]  S. Singletary,et al.  A case–control study of unilateral and bilateral breast carcinoma patients , 2001, Cancer.

[35]  S. Schnitt,et al.  Breast‐conserving therapy for Stage I‐II synchronous bilateral breast carcinoma , 1997, Cancer.

[36]  M. Sroor,et al.  Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. , 2015, Asian Pacific journal of cancer prevention : APJCP.

[37]  D. Roder,et al.  Survival from synchronous bilateral breast cancer: the experience of surgeons participating in the breast audit of the Society of Breast Surgeons of Australia and New Zealand. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[38]  U. Demirci,et al.  Clinicopathological features in bilateral breast cancer. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[39]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.