Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3‐kinase
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J. Downward | C. Martínez-A | I. Mérida | P. Rodriguez-Viciana | V. Calvo | A. González-García | J. Albar | E. Leonardo | S. Wennström | A. Carrera | E. Díez | C. von Kobbe | M. Gaspar | DavidR . Jones | J. Torán | C. Jiménez | L. R.-Borlado | M. Marcos | S. Copin | L. R.‐Borlado | Concepción Jiménez
[1] Jonathan A. Cooper,et al. p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes* , 1997, The Journal of Biological Chemistry.
[2] P. Warne,et al. Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras , 1997, Cell.
[3] C. Martínez-A,et al. Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. , 1997, Journal of immunology.
[4] M. Zvelebil,et al. p110δ, a novel phosphoinositide 3-kinase in leukocytes , 1997 .
[5] P. Cohen,et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.
[6] Y. Yazaki,et al. p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin* , 1997, The Journal of Biological Chemistry.
[7] N. Hay,et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. , 1997, Genes & development.
[8] J. Backer,et al. Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways , 1997, Molecular and cellular biology.
[9] D. Pot,et al. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain , 1997, Molecular and cellular biology.
[10] E. Hafen,et al. The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth. , 1996, The EMBO journal.
[11] L. Cantley,et al. Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene , 1996 .
[12] G. Cooper,et al. Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. , 1996, Oncogene.
[13] J. Downward,et al. Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. , 1996, The EMBO journal.
[14] C. Kahn,et al. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain , 1996, Molecular and cellular biology.
[15] Y. Yazaki,et al. A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85 Gene (*) , 1996, The Journal of Biological Chemistry.
[16] M. Zvelebil,et al. Structural and functional diversity of phosphoinositide 3-kinases. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[17] P. Majerus,et al. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[18] L. Cantley,et al. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins , 1995, Cell.
[19] M. Waterfield,et al. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction , 1995, Current Biology.
[20] T. Hunter,et al. When is a lipid kinase not a lipid kinase? When it is a protein kinase , 1995, Cell.
[21] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[22] M. White,et al. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase , 1995, Molecular and cellular biology.
[23] T. Roberts,et al. Role of the autophosphorylation site on the biological function of pp56lck. , 1995, Oncogene.
[24] Andrius Kazlauskas,et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.
[25] C. Nobes,et al. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia , 1995, Cell.
[26] P. Hawkins,et al. PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase , 1995, Current Biology.
[27] F. Alt,et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation , 1995, Cell.
[28] R. Lindberg,et al. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. , 1995, Oncogene.
[29] A. Toker,et al. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. , 1994, The Journal of biological chemistry.
[30] M. Czech,et al. Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit. , 1994, The Journal of biological chemistry.
[31] M. Koegl,et al. The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[32] Peter J. Parker,et al. The activation of phosphatidylinositol 3-kinase by Ras , 1994, Current Biology.
[33] Andrius Kazlauskas,et al. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase , 1994, Nature.
[34] M. Kasuga,et al. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling , 1994, Current Biology.
[35] M. Hirano,et al. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. , 1994, Molecular and cellular biology.
[36] J. Cambier,et al. Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. , 1994, Science.
[37] M. Kasuga,et al. PI 3‐kinase: structural and functional analysis of intersubunit interactions. , 1994, The EMBO journal.
[38] L. Olson,et al. Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits , 1994, Molecular and cellular biology.
[39] J. Schlessinger,et al. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 , 1993, Molecular and cellular biology.
[40] P. Hawkins,et al. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? , 1993, Biochimica et biophysica acta.
[41] J. Pessin,et al. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. , 1993, The Journal of biological chemistry.
[42] I. Gout,et al. Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation. , 1993, The Journal of biological chemistry.
[43] L. Cantley,et al. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity , 1993, Molecular and cellular biology.
[44] G. Panayotou,et al. Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes. , 1992, Trends in cell biology.
[45] S. Volinia,et al. Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit , 1992, Cell.
[46] I. Weissman,et al. Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis , 1992, The Journal of experimental medicine.
[47] J. Blenis,et al. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK , 1992, Cell.
[48] I. Mérida,et al. IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase. , 1991, Journal of immunology.
[49] T. Roberts,et al. Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck. , 1991, International Immunology.
[50] V. Fried,et al. cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor , 1991, Cell.
[51] A. Ullrich,et al. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases , 1991, Cell.
[52] G. Panayotou,et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase , 1991, Cell.
[53] L. Cantley,et al. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. , 1989, The Journal of biological chemistry.
[54] R. Coffman,et al. cDNA clones encoding IgE-binding factors from a rat-mouse T-cell hybridoma. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[55] E. Lund,et al. Human U1 RNA genes contain an unusually sensitive nuclease S1 cleavage site within the conserved 3' flanking region. , 1984, Proceedings of the National Academy of Sciences of the United States of America.