Preparation and characterization of erythromycin molecularly imprinted polymers based on distillation-precipitation polymerization.

Erythromycin-imprinted polymers with excellent recognition properties were prepared by an innovative strategy called distillation-precipitation polymerization. The interaction between erythromycin and methacrylic acid was studied by ultraviolet absorption spectroscopy, and the as-prepared materials were characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. Moreover, their binding performances were evaluated in detail by static, kinetic and selective sorption tests. It was found that the molecularly imprinted polymers afforded good morphology, monodispersity, and high adsorption capacity when the fraction of the monomers was 7 vol% in the whole reaction system, and the adsorption data for imprinted polymers correlated well with the Langmuir model. The maximum capacity of the imprinted and the non-imprinted polymers for adsorbing erythromycin is 44.03 and 19.95 mg/g, respectively. The kinetic studies revealed that the adsorption process fitted a pseudo-second-order kinetic model. Furthermore, the imprinted polymers display higher affinity toward erythromycin, compared with its analogue roxithromycin.

[1]  Limin He,et al.  Simultaneous determination of quinoxaline-1,4-dioxides in feeds using molecularly imprinted solid-phase extraction coupled with HPLC. , 2013, Journal of separation science.

[2]  Erkang Wang,et al.  Fe3O4 magnetic nanoparticles as peroxidase mimetics and their applications in H2O2 and glucose detection. , 2008, Analytical chemistry.

[3]  M. Gomes,et al.  Thin-film electrochemical sensor for diphenylamine detection using molecularly imprinted polymers. , 2014, Analytica chimica acta.

[4]  L. Ye,et al.  Molecularly imprinted polymer beads for nicotine recognition prepared by RAFT precipitation polymerization: a step forward towards multi-functionalities , 2014 .

[5]  Faiz Ali,et al.  Molecular imprinted polymers for separation science: a review of reviews. , 2013, Journal of separation science.

[6]  N. Thomaidis,et al.  Molecularly imprinted polymers for bisphenol A for HPLC and SPE from water and milk. , 2008, Journal of separation science.

[7]  P. Dubruel,et al.  Development of suspension polymerized molecularly imprinted beads with metergoline as template and application in a solid-phase extraction procedure toward ergot alkaloids. , 2012, Analytical chemistry.

[8]  T. Sun,et al.  Selective adsorption of antimony(III) from aqueous solution by ion-imprinted organic–inorganic hybrid sorbent: Kinetics, isotherms and thermodynamics , 2014 .

[9]  정원조.  Molecular imprinted polymers for separation science: A review of reviews , 2013 .

[10]  Liu Yuan,et al.  Fabrication of highly sensitive and selective electrochemical sensor by using optimized molecularly imprinted polymers on multi-walled carbon nanotubes for metronidazole measurement , 2015 .

[11]  M. Monier,et al.  Synthesis and characterization of selective thiourea modified Hg(II) ion-imprinted cellulosic cotton fibers. , 2014, Carbohydrate polymers.

[12]  Fangbin Chen,et al.  Molecularly imprinted microspheres for the anticancer drug aminoglutethimide: synthesis, characterization, and solid-phase extraction applications in human urine samples. , 2014, Journal of Separation Science.

[13]  Bin Du,et al.  A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples. , 2014, Talanta.

[14]  Langchong He,et al.  Preparation of molecularly imprinted polymer for sinomenine and study on its molecular recognition mechanism , 2006 .

[15]  Langchong He,et al.  Preparation and Evaluation of Uniform-size (-)-Ephedrine-imprinted Polymeric Microspheres by Multi-step Swelling and Suspension Polymerization , 2006, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[16]  Yongsheng Yan,et al.  Magnetic molecularly imprinted microcapsules derived from Pickering emulsion polymerization and their novel adsorption characteristics for λ-cyhalothrin , 2014 .

[17]  Lingxin Chen,et al.  Double water compatible molecularly imprinted polymers applied as solid-phase extraction sorbent for selective preconcentration and determination of triazines in complicated water samples. , 2014, Journal of chromatography. A.

[18]  N. Das,et al.  Mechanism of Cd(II) adsorption by macrofungus Pleurotus platypus. , 2011, Journal of environmental sciences.

[19]  S. Chough,et al.  In situ preparation of powder and the sorption behaviors of molecularly imprinted polymers through the complexation between polymer ion of methyl methacrylate/acrylic acid and Ca++ ion. , 2014, Analytica chimica acta.

[20]  G. Wulff,et al.  Molecularly imprinted polymers with strong carboxypeptidase a-like activity: combination of an amidinium function with a zinc-ion binding site in transition-state imprinted cavities. , 2004, Angewandte Chemie.

[21]  C. Au,et al.  Magnetic ion-imprinted and –SH functionalized polymer for selective removal of Pb(II) from aqueous samples , 2014 .

[22]  Hongbing Ji,et al.  2-Hydroxypropyl-β-cyclodextrin Polymer as a Mimetic Enzyme for Mediated Synthesis of Benzaldehyde in Water , 2013 .

[23]  Jianming Pan,et al.  Selective recognition of 4-nitrophenol from aqueous solution by molecularly imprinted polymers with functionalized tetratitanate whisker composites as support. , 2011, Journal of separation science.

[24]  P. Jandera,et al.  Molecularly imprinted polymer for solid-phase extraction of ephedrine and analogs from human plasma. , 2009, Journal of separation science.

[25]  Yingchun Li,et al.  Preparation of molecularly imprinted polymer with double templates for rapid simultaneous determination of melamine and dicyandiamide in dairy products. , 2015, Talanta.

[26]  K. Müllen,et al.  Nonaqueous emulsion polymerization: A practical synthetic route for the production of molecularly imprinted nanospheres , 2013 .

[27]  W. Shi,et al.  Fabrication and evaluation of molecularly imprinted multi-hollow microspheres adsorbents with tunable inner pore structures derived from templating Pickering double emulsions , 2015 .

[28]  Wenqiang Huang,et al.  Synthesis of Narrow or Monodisperse Poly(divinylbenzene) Microspheres by Distillation−Precipitation Polymerization , 2004 .

[29]  Karsten Haupt,et al.  Imprinted polymers-tailor-made mimics of antibodies and receptors. , 2003, Chemical communications.

[30]  Langchong He,et al.  Concentration and extraction of sinomenine from herb and plasma using a molecularly imprinted polymer as the stationary phase , 2006 .

[31]  Xinlin Yang,et al.  Monodisperse hydrophilic polymer microspheres having carboxylic acid groups prepared by distillation precipitation polymerization , 2006 .

[32]  Wenqiang Huang,et al.  Synthesis of monodisperse poly(methacrylic acid) microspheres by distillation–precipitation polymerization , 2007 .

[33]  Yang Sun,et al.  Selective removal of antimony(III) from aqueous solution using antimony(III)-imprinted organic–inorganic hybrid sorbents by combination of surface imprinting technique with sol–gel process , 2014 .

[34]  Yingchun Li,et al.  Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors , 2015, Scientific Reports.

[35]  Yan Liu,et al.  Preparation of ion-imprinted mesoporous silica SBA-15 functionalized with triglycine for selective adsorption of Co(II) , 2013 .

[36]  Hongyuan Yan,et al.  Dispersive solid-phase extraction based on magnetic dummy molecularly imprinted microspheres for selective screening of phthalates in plastic bottled beverages. , 2014, Journal of agricultural and food chemistry.

[37]  Xinlin Yang,et al.  Preparation of narrow‐dispersion or monodisperse polymer microspheres with active hydroxyl group by distillation–precipitation polymerization , 2006 .

[38]  Lu Zhang,et al.  Synthesis of metronidazole-imprinted molecularly imprinted polymers by distillation precipitation polymerization and their use as a solid-phase adsorbent and chromatographic filler. , 2015, Journal of separation science.