Photoresponsive nanoparticles for drug delivery.

Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy while reducing side effects. Light is a versatile and easily tuned external stimulus that can provide spatiotemporal control. Here we will review the use of nanoparticles in which light triggers drug release or induces particle binding to tissues (phototargeting).

[1]  Nelson Durán,et al.  New aspects of nanopharmaceutical delivery systems. , 2008, Journal of nanoscience and nanotechnology.

[2]  R. Zhuo,et al.  Steric Protected and Illumination‐Activated Tumor Targeting Accessory for Endowing Drug‐Delivery Systems with Tumor Selectivity , 2014 .

[3]  Juan L. Vivero-Escoto,et al.  Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. , 2008, Advanced drug delivery reviews.

[4]  Adah Almutairi,et al.  UV and near-IR triggered release from polymeric nanoparticles. , 2010, Journal of the American Chemical Society.

[5]  Guoying Zhang,et al.  Self-immolative polymersomes for high-efficiency triggered release and programmed enzymatic reactions. , 2014, Journal of the American Chemical Society.

[6]  Jinsheng Zheng,et al.  Molecule-scale controlled-release system based on light-responsive silica nanoparticles. , 2008, Chemical communications.

[7]  J. Allard,et al.  Near-infrared light sensitive polypeptide block copolymer micelles for drug delivery , 2012 .

[8]  B. Sarmento,et al.  Novel non-invasive methods of insulin delivery , 2012, Expert opinion on drug delivery.

[9]  Yong Zhang,et al.  Near-infrared-light-based nano-platform boosts endosomal escape and controls gene knockdown in vivo. , 2014, ACS nano.

[10]  A. Sharma,et al.  Photoregulation of drug release in azo-dextran nanogels. , 2007, International journal of pharmaceutics.

[11]  Paula T. Hammond,et al.  A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin , 2014, Journal of the American Chemical Society.

[12]  Kevin Braeckmans,et al.  Intracellular delivery of nanomaterials: how to catch endosomal escape in the act , 2014 .

[13]  Juanjuan Peng,et al.  Near‐Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk‐Shell Upconversion Nanocages , 2014 .

[14]  J. Ho,et al.  Photocontrolled targeted drug delivery: photocaged biologically active folic acid as a light-responsive tumor-targeting molecule. , 2012, Angewandte Chemie.

[15]  Jakob Wirz,et al.  Photoremovable protecting groups: reaction mechanisms and applications , 2002, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[16]  Wei Fan,et al.  Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri‐doped Upconversion Colloidal Nanoparticles at 800 nm , 2013 .

[17]  Jeffrey I. Zink,et al.  Photo-Driven Expulsion of Molecules from Mesostructured Silica Nanoparticles , 2007 .

[18]  Shiwei Wu,et al.  Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals , 2009, Proceedings of the National Academy of Sciences.

[19]  Gert Storm,et al.  Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[20]  S. Thayumanavan,et al.  Photoregulated release of noncovalent guests from dendritic amphiphilic nanocontainers. , 2011, Angewandte Chemie.

[21]  Fang Liu,et al.  NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion nanoparticles. , 2013, Nanoscale.

[22]  Masahiro Fujiwara,et al.  Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica , 2003, Nature.

[23]  Fuyou Li,et al.  Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process. , 2010, Journal of the American Chemical Society.

[24]  Hai Zhu,et al.  Upconverting near-infrared light through energy management in core-shell-shell nanoparticles. , 2013, Angewandte Chemie.

[25]  B. Bouma,et al.  Three-dimensional miniature endoscopy , 2006, Nature.

[26]  Shuai Shao,et al.  Porphyrin–phospholipid liposomes permeabilized by near-infrared light , 2014, Nature Communications.

[27]  Y. Talmon,et al.  Photo-assisted gene delivery using light-responsive catanionic vesicles. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[28]  David Ogden,et al.  From one-photon to two-photon probes: "caged" compounds, actuators, and photoswitches. , 2013, Angewandte Chemie.

[29]  K. Shakesheff,et al.  Polymeric systems for controlled drug release. , 1999, Chemical reviews.

[30]  W J BOWEN,et al.  The absorption spectra and extinction coefficients of myoglobin. , 1949, The Journal of biological chemistry.

[31]  Maria O. Ogunyankin,et al.  Modular Plasmonic Nanocarriers for Efficient and Targeted Delivery of Cancer-Therapeutic siRNA , 2014, Nano letters.

[32]  Juan L. Vivero-Escoto,et al.  Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere. , 2009, Journal of the American Chemical Society.

[33]  Wah Chiu,et al.  Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells. , 2008, Journal of the American Chemical Society.

[34]  M S Patterson,et al.  Optical properties of normal and diseased human breast tissues in the visible and near infrared. , 1990, Physics in medicine and biology.

[35]  Xianglong Hu,et al.  Photo-Triggered Release of Caged Camptothecin Prodrugs from Dually Responsive Shell Cross-Linked Micelles , 2013 .

[36]  Nancy R. Sottos,et al.  Triggered Release from Polymer Capsules , 2011 .

[37]  Naomi J. Halas,et al.  Light-induced release of DNA from plasmon-resonant nanoparticles: Towards light-controlled gene therapy , 2009 .

[38]  Jean-François Gohy,et al.  Photo-responsive block copolymer micelles: design and behavior. , 2013, Chemical Society reviews.

[39]  D. Kohane,et al.  Drug-Delivery Systems for Tunable and Localized Drug Release , 2013 .

[40]  Gonen Ashkenasy,et al.  Light induced drug delivery into cancer cells. , 2011, Biomaterials.

[41]  J. Zink,et al.  Two-photon-triggered drug delivery in cancer cells using nanoimpellers. , 2013, Angewandte Chemie.

[42]  Heike Bunjes,et al.  Lipid nanoparticles for the delivery of poorly water‐soluble drugs , 2010, The Journal of pharmacy and pharmacology.

[43]  B. Bondurant,et al.  Rapid release of liposomal contents upon photoinitiated destabilization with UV exposure. , 2003, Biochimica et biophysica acta.

[44]  Daniel S. Kohane,et al.  Materials to clinical devices: technologies for remotely triggered drug delivery. , 2012, Clinical therapeutics.

[45]  Yue Zhao,et al.  How can azobenzene block copolymer vesicles be dissociated and reformed by light? , 2005, The journal of physical chemistry. B.

[46]  Wei Wei,et al.  Engineering lanthanide-based materials for nanomedicine , 2014 .

[47]  Venkata Krishna Kotharangannagari,et al.  Photoresponsive Reversible Aggregation and Dissolution of Rod–Coil Polypeptide Diblock Copolymers , 2011 .

[48]  Ashleyj . Welch,et al.  Optical-Thermal Response of Laser-Irradiated Tissue , 1995 .

[49]  Kazunori Kataoka,et al.  Polyion complex vesicles for photoinduced intracellular delivery of amphiphilic photosensitizer. , 2014, Journal of the American Chemical Society.

[50]  Jin-Zhi Du,et al.  Shell-detachable nanoparticles based on a light-responsive amphiphile for enhanced siRNA delivery , 2014 .

[51]  R. Steiner Laser-Tissue Interactions , 2011 .

[52]  H. Möhwald,et al.  Polymeric microcapsules with light responsive properties for encapsulation and release. , 2010, Advances in colloid and interface science.

[53]  Fang Liu,et al.  Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles. , 2014, Angewandte Chemie.

[54]  Kristi S Anseth,et al.  Wavelength-controlled photocleavage for the orthogonal and sequential release of multiple proteins. , 2013, Angewandte Chemie.

[55]  A. Concheiro,et al.  CHAPTER 12:UV and Near-IR Triggered Release from Polymeric Micelles and Nanoparticles , 2013 .

[56]  Bangshang Zhu,et al.  Light-responsive linear-dendritic amphiphiles and their nanomedicines for NIR-triggered drug release , 2014 .

[57]  C G Morgan,et al.  Active Uptake of Drugs into Photosensitive Liposomes and Rapid Release on UV Photolysis¶ , 2000, Photochemistry and photobiology.

[58]  S. Nie,et al.  Therapeutic Nanoparticles for Drug Delivery in Cancer Types of Nanoparticles Used as Drug Delivery Systems , 2022 .

[59]  D. Zhao,et al.  Highly efficient lanthanide upconverting nanomaterials: Progresses and challenges , 2013 .

[60]  Xinjing Tang,et al.  Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release. , 2013, ChemPlusChem.

[61]  J. Boyer,et al.  Remote-control photorelease of caged compounds using near-infrared light and upconverting nanoparticles. , 2010, Angewandte Chemie.

[62]  Wei Feng,et al.  Upconversion luminescent materials: advances and applications. , 2015, Chemical reviews.

[63]  Linyong Zhu,et al.  Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles , 2013, Advanced materials.

[64]  Ying-Wei Yang,et al.  Dual-controlled nanoparticles exhibiting AND logic. , 2009, Journal of the American Chemical Society.

[65]  C. Raulin,et al.  Laser and IPL technology in dermatology and aesthetic medicine , 2011 .

[66]  María Vallet-Regí,et al.  Mesoporous silica nanoparticles for the design of smart delivery nanodevices. , 2013, Biomaterials science.

[67]  Matthew Tirrell,et al.  Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates. , 2009, ACS nano.

[68]  Xiaofei Ma,et al.  NIR-responsive and lectin-binding doxorubicin-loaded nanomedicine from Janus-type dendritic PAMAM amphiphiles. , 2012, Biomacromolecules.

[69]  M. Matsusaki,et al.  Photo-Cross-Linking and Cleavage Induced Reversible Size Change of Bio-Based Nanoparticles , 2008 .

[70]  Robert Langer,et al.  Impact of nanotechnology on drug delivery. , 2009, ACS nano.

[71]  A. J. Tavares,et al.  Near-infrared-triggered anticancer drug release from upconverting nanoparticles. , 2014, ACS applied materials & interfaces.

[72]  R Langer,et al.  Responsive polymeric delivery systems. , 2001, Advanced drug delivery reviews.

[73]  Jeffrey I Zink,et al.  Light-activated nanoimpeller-controlled drug release in cancer cells. , 2008, Small.

[74]  Robert Langer,et al.  Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. , 2011, Nano letters.

[75]  Wei Qian,et al.  Ultrafast cooling of photoexcited electrons in gold nanoparticle-thiolated DNA conjugates involves the dissociation of the gold-thiol bond. , 2006, Journal of the American Chemical Society.

[76]  Adah Almutairi,et al.  Low Power Upconverted Near‐IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release , 2013, Advanced materials.

[77]  J. Cadet,et al.  Riboflavin and UV-Light Based Pathogen Reduction: Extent and Consequence of DNA Damage at the Molecular Level , 2004, Photochemistry and photobiology.

[78]  Brian P. Timko,et al.  Photo-targeted nanoparticles. , 2010, Nano letters.

[79]  C. Sheridan Proof of concept for next-generation nanoparticle drugs in humans , 2012, Nature Biotechnology.

[80]  R. Bellamkonda,et al.  Remote triggered release of doxorubicin in tumors by synergistic application of thermosensitive liposomes and gold nanorods. , 2011, ACS nano.

[81]  Taeghwan Hyeon,et al.  Upconverting nanoparticles: a versatile platform for wide-field two-photon microscopy and multi-modal in vivo imaging. , 2015, Chemical Society reviews.

[82]  R. Langer,et al.  Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery , 2012, Journal of the American Chemical Society.

[83]  Brian P. Timko,et al.  Remotely Triggerable Drug Delivery Systems , 2010, Advanced materials.

[84]  Yugui Yang,et al.  Researches on the Constitutive Models of Artificial Frozen Silt in Underground Engineering , 2014 .

[85]  C. Palivan,et al.  Photoresponsive polymersomes as smart, triggerable nanocarriers , 2011 .

[86]  Zheng Huang,et al.  A Review of Progress in Clinical Photodynamic Therapy , 2005, Technology in cancer research & treatment.

[87]  O. Planinšek,et al.  Stimulus-responsive mesoporous silica particles , 2013, Journal of Materials Science.

[88]  Carmen Alvarez-Lorenzo,et al.  Light‐sensitive Intelligent Drug Delivery Systems † , 2009, Photochemistry and photobiology.

[89]  Dongyun Chen,et al.  Light-responsive amphiphilic copolymer coated nanoparticles as nanocarriers and real-time monitors for controlled drug release. , 2014, Journal of materials chemistry. B.

[90]  X. Qu,et al.  Near‐Infrared Light‐Encoded Orthogonally Triggered and Logical Intracellular Release Using Gold Nanocage@Smart Polymer Shell , 2014 .

[91]  Kristi S. Anseth,et al.  Photocontrolled Nanoparticles for On-Demand Release of Proteins , 2012, Biomacromolecules.

[92]  T. Cai,et al.  Light and pH dual-degradable triblock copolymer micelles for controlled intracellular drug release. , 2014, Macromolecular rapid communications.

[93]  L. Packer,et al.  UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin. , 1998, Free radical biology & medicine.

[94]  Xiaohong Wang,et al.  Synthesis of multi-responsive polymeric nanocarriers for controlled release of bioactive agents , 2013 .

[95]  Marek Romanowski,et al.  NIR-activated content release from plasmon resonant liposomes for probing single-cell responses. , 2012, ACS nano.

[96]  D. Thompson,et al.  Triggerable plasmalogen liposomes: improvement of system efficiency. , 1996, Biochimica et biophysica acta.

[97]  Jun Lin,et al.  In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconverison nanoparticles. , 2013, Journal of the American Chemical Society.

[98]  John-Christopher Boyer,et al.  Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles. , 2011, Journal of the American Chemical Society.

[99]  Wei Feng,et al.  The biosafety of lanthanide upconversion nanomaterials. , 2015, Chemical Society reviews.

[100]  J. Burdick,et al.  Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes. , 2010, Journal of the American Chemical Society.

[101]  D. Kohane,et al.  Prospects for near-infrared technology in remotely triggered drug delivery , 2014, Expert opinion on drug delivery.

[102]  Robert Langer,et al.  Biocompatibility and drug delivery systems , 2010 .

[103]  Linyong Zhu,et al.  Light and reductive dual stimuli-responsive PEI nanoparticles: "AND" logic response and controllable release. , 2014, Journal of materials chemistry. B.

[104]  A. C. Mitchell,et al.  Light-induced fusion of liposomes with release of trapped marker dye is sensitised by photochromic phospholipid. , 1987, Biochimica et biophysica acta.

[105]  Ken Barat Laser Safety : Tools and Training , 2008 .

[106]  A. Bangham,et al.  Diffusion of univalent ions across the lamellae of swollen phospholipids. , 1965, Journal of molecular biology.

[107]  Vincent M. Rotello,et al.  Triggered Nanoparticles as Therapeutics. , 2013, Nano today.

[108]  J. Santamaría,et al.  Au-PLA nanocomposites for photothermally controlled drug delivery. , 2014, Journal of materials chemistry. B.

[109]  David H. Thompson,et al.  Phototriggering of liposomal drug delivery systems. , 2001, Advanced drug delivery reviews.

[110]  Adah Almutairi,et al.  Photochemical mechanisms of light-triggered release from nanocarriers. , 2012, Advanced drug delivery reviews.

[111]  Wei Liu,et al.  UV- and NIR-responsive polymeric nanomedicines for on-demand drug delivery , 2013 .

[112]  Xiaobing Zhang,et al.  Photon-manipulated drug release from a mesoporous nanocontainer controlled by azobenzene-modified nucleic acid. , 2012, ACS nano.

[113]  G. Fleming,et al.  Synthetic micelle sensitive to IR light via a two-photon process. , 2005, Journal of the American Chemical Society.

[114]  Artur Bednarkiewicz,et al.  Upconverting nanoparticles: assessing the toxicity. , 2015, Chemical Society reviews.

[115]  Qiang Sun,et al.  Mechanistic investigation of photon upconversion in Nd(3+)-sensitized core-shell nanoparticles. , 2013, Journal of the American Chemical Society.

[116]  P. Jain,et al.  Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. , 2006, The journal of physical chemistry. B.

[117]  J. Karp,et al.  Nanocarriers as an Emerging Platform for Cancer Therapy , 2022 .

[118]  Probal Banerjee,et al.  Core-shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment. , 2010, Biomaterials.

[119]  V. V. Tuchin Light scattering study of tissues , 1997 .

[120]  R. Langer,et al.  Photothermally targeted thermosensitive polymer-masked nanoparticles. , 2014, Nano letters.

[121]  J. Gohy,et al.  Multiresponsive Micellar Systems from Photocleavable Block Copolymers. , 2012, ACS macro letters.

[122]  R. Givens,et al.  Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy , 2012, Chemical reviews.

[123]  Muthu Kumara Gnanasammandhan Jayakumar,et al.  Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications. , 2015, Chemical Society reviews.

[124]  R. Weissleder A clearer vision for in vivo imaging , 2001, Nature Biotechnology.

[125]  Yu-Lin Chou,et al.  Near-infrared light photocontrolled targeting, bioimaging, and chemotherapy with caged upconversion nanoparticles in vitro and in vivo. , 2013, ACS nano.

[126]  Vasilis Ntziachristos,et al.  Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata. , 2002, Optics letters.

[127]  C. Goodwin,et al.  Apoptosis and accidental cell death in cultured human keratinocytes after thermal injury. , 1998, The American journal of pathology.

[128]  Jianlin Shi,et al.  In Vivo Bio‐Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles , 2013, Advanced materials.

[129]  María Vallet-Regí,et al.  Mesoporous materials for drug delivery. , 2007, Angewandte Chemie.

[130]  P. Prasad,et al.  Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics , 2014, Chemical reviews.

[131]  Yue Zhao,et al.  A new design for light-breakable polymer micelles. , 2005, Journal of the American Chemical Society.

[132]  Panagiotis Argitis,et al.  Harnessing photochemical internalization with dual degradable nanoparticles for combinatorial photo–chemotherapy , 2014, Nature Communications.

[133]  Dongmei Yang,et al.  Current advances in lanthanide ion (Ln(3+))-based upconversion nanomaterials for drug delivery. , 2015, Chemical Society reviews.

[134]  S. Jacques Optical properties of biological tissues: a review , 2013, Physics in medicine and biology.

[135]  D. Schmaljohann Thermo- and pH-responsive polymers in drug delivery. , 2006, Advanced drug delivery reviews.

[136]  D. Yan,et al.  Photo-responsive polymeric micelles. , 2014, Soft matter.

[137]  Lawrence Tamarkin,et al.  Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine , 2010, Clinical Cancer Research.

[138]  M. Kohl,et al.  Near-infrared optical properties of ex vivo human skin and subcutaneous tissues measured using the Monte Carlo inversion technique. , 1998, Physics in medicine and biology.

[139]  Robert Blumenthal,et al.  A novel class of photo-triggerable liposomes containing DPPC:DC(8,9)PC as vehicles for delivery of doxorubcin to cells. , 2011, Biochimica et biophysica acta.

[140]  T. Taguchi,et al.  Photo-Switched Storage and Release of Guest Molecules in the Pore Void of Coumarin-Modified MCM-41 , 2003 .

[141]  R. Schiff,et al.  Sub-100nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumors. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[142]  Adah Almutairi,et al.  Low power, biologically benign NIR light triggers polymer disassembly. , 2011, Macromolecules.

[143]  Robert Langer,et al.  Near-infrared–actuated devices for remotely controlled drug delivery , 2014, Proceedings of the National Academy of Sciences.

[144]  Martin Frenz,et al.  Mechanisms of nanoparticle-mediated photomechanical cell damage , 2012, Biomedical optics express.

[145]  P. Bergethon,et al.  A photodependent switch of liposome stability and permeability. , 2013, Langmuir : the ACS journal of surfaces and colloids.

[146]  Zhiyuan Zhong,et al.  Stimuli-responsive polymersomes for programmed drug delivery. , 2009, Biomacromolecules.

[147]  Warren C W Chan,et al.  The effect of nanoparticle size, shape, and surface chemistry on biological systems. , 2012, Annual review of biomedical engineering.

[148]  X. Qu,et al.  DNA‐mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near‐Infrared Light Triggered Release , 2014, Advanced materials.

[149]  A. Singh,et al.  Polymerized phosphatidylcholine vesicles. Synthesis and characterization , 1982 .

[150]  Xiaogang Liu,et al.  NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release. , 2013, Small.

[151]  Peng Wang,et al.  Photodegradable polyurethane self-assembled nanoparticles for photocontrollable release. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[152]  Kazunori Kataoka,et al.  Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer , 2005, Nature materials.

[153]  Shanshan Huang,et al.  Near-infrared light-triggered micelles for fast controlled drug release in deep tissue. , 2013, Biomaterials.

[154]  Robert Langer,et al.  Nanomedicine in the Management of Microbial Infection - Overview and Perspectives. , 2014, Nano today.

[155]  Ekaterina Lukianova,et al.  Method of laser activated nano-thermolysis for elimination of tumor cells. , 2006, Cancer letters.

[156]  W. Meier,et al.  Synthesis of Photocleavable Amphiphilic Block Copolymers: Toward the Design of Photosensitive Nanocarriers , 2010 .

[157]  Guoying Zhang,et al.  Concurrent block copolymer polymersome stabilization and bilayer permeabilization by stimuli-regulated "traceless" crosslinking. , 2014, Angewandte Chemie.

[158]  Jun Lin,et al.  Functionalized mesoporous silica materials for controlled drug delivery. , 2012, Chemical Society reviews.

[159]  N. Halas,et al.  Visualizing light-triggered release of molecules inside living cells. , 2010, Nano letters.

[160]  Rijun Gui,et al.  Intracellular fluorescent thermometry and photothermal-triggered drug release developed from gold nanoclusters and doxorubicin dual-loaded liposomes. , 2014, Chemical communications.

[161]  Yen Wei,et al.  Two-photon-sensitive and sugar-targeted nanocarriers from degradable and dendritic amphiphiles. , 2011, Small.

[162]  Wei Feng,et al.  Water-soluble lanthanide upconversion nanophosphors: Synthesis and bioimaging applications in vivo , 2014 .

[163]  Yue Zhao,et al.  Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles , 2006 .

[164]  Kristian Berg,et al.  Photochemical internalisation in drug and gene delivery. , 2004, Advanced drug delivery reviews.

[165]  Younan Xia,et al.  Gold nanocages covered by smart polymers for controlled release with near-infrared light , 2009, Nature materials.

[166]  B. Hooper Optical-thermal response of laser-irradiated tissue , 1996 .

[167]  Daniel S. Kohane,et al.  Photoswitchable nanoparticles for in vivo cancer chemotherapy , 2013, Proceedings of the National Academy of Sciences.

[168]  Vladimir P. Zharov,et al.  Microbubbles-overlapping mode for laser killing of cancer cells with absorbing nanoparticle clusters , 2005 .

[169]  Guoying Zhang,et al.  Light-triggered concomitant enhancement of magnetic resonance imaging contrast performance and drug release rate of functionalized amphiphilic diblock copolymer micelles. , 2012, Biomacromolecules.

[170]  F. Auzel Upconversion and anti-Stokes processes with f and d ions in solids. , 2004, Chemical reviews.

[171]  M. Yeh,et al.  Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy , 2011, International journal of nanomedicine.

[172]  K. Kataoka,et al.  Block copolymer micelles for drug delivery: design, characterization and biological significance. , 2001, Advanced drug delivery reviews.

[173]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[174]  Xing Ma,et al.  Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery in vivo. , 2012, Angewandte Chemie.

[175]  L. Liang,et al.  Nanoparticle-based delivery system for application of siRNA in vivo. , 2010, Current drug metabolism.

[176]  M. El-Sayed,et al.  Spectral Properties and Relaxation Dynamics of Surface Plasmon Electronic Oscillations in Gold and Silver Nanodots and Nanorods , 1999 .

[177]  A. Kabanov,et al.  Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. , 2009, Angewandte Chemie.

[178]  R. Langer,et al.  A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. , 2010, Biomaterials.

[179]  Ekaterina Lukianova,et al.  Selective laser nano‐thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles , 2006, Lasers in surgery and medicine.

[180]  R. Truscott,et al.  Photo-oxidation of proteins and its role in cataractogenesis. , 2001, Journal of photochemistry and photobiology. B, Biology.

[181]  Jianan Liu,et al.  NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica. , 2013, Angewandte Chemie.

[182]  R. Glickman,et al.  Phototoxicity to the Retina: Mechanisms of Damage , 2002, International journal of toxicology.

[183]  Maurice Goeldner,et al.  Dynamic studies in biology : phototriggers, photoswitches and caged biomolecules , 2005 .

[184]  J. Boulnois,et al.  Photophysical processes in recent medical laser developments: A review , 2005, Lasers in Medical Science.

[185]  M. Blumenkranz,et al.  Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: additional information regarding baseline lesion composition's impact on vision outcomes-TAP report No. 3. , 2002, Archives of ophthalmology.

[186]  M. Matsusaki,et al.  Photo-tunable protein release from biodegradable nanoparticles composed of cinnamic acid derivatives. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[187]  J. Allard,et al.  A new two-photon-sensitive block copolymer nanocarrier. , 2009, Angewandte Chemie.

[188]  Lin Ji,et al.  Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. , 2012, ACS nano.