Wilson–Mikity syndrome: Updated diagnostic criteria based on nine cases and a review of the literature

Nearly 50 years ago, Wilson and Mikity described a syndrome (WMS) of chronic lung disease (CLD) in premature infants, characterized by early development of cystic interstitial emphysema (PIE), despite minimal ventilatory support. The validity of the diagnosis is currently unclear; now considered either an anachronism, part of BPD spectrum or included within various poorly defined diagnoses such as chronic pulmonary insufficiency of prematurity (CPIP).

[1]  B. Thébaud.  Angiogenesis in Lung Development, Injury and Repair: Implications for Chronic Lung Disease of Prematurity , 2007, Neonatology.

[2]  C. D’Angio,et al.  Pathogenesis of bronchopulmonary dysplasia. , 2006, Seminars in perinatology.

[3]  R. Markowitz,et al.  Lung Disease in Premature Neonates: Radiologic-Pathologic Correlation , 2005 .

[4]  J. Wit,et al.  Changes in Neonatology: Comparison of Two Cohorts of Very Preterm Infants (Gestational Age <32 Weeks): The Project on Preterm and Small for Gestational Age Infants 1983 and The Leiden Follow-Up Project on Prematurity 1996-1997 , 2005, Pediatrics.

[5]  W. Carlo,et al.  Bronchopulmonary dysplasia: new insights. , 2004, Clinics in perinatology.

[6]  J. Hodgman.  Relationship between Wilson-Mikity syndrome and the new bronchopulmonary dysplasia. , 2003, Pediatrics.

[7]  R. Ehrenkranz,et al.  Statement on the care of the child with chronic lung disease of infancy and childhood. , 2003, American journal of respiratory and critical care medicine.

[8]  O. Saugstad.  Bronchopulmonary dysplasia-oxidative stress and antioxidants. , 2003, Seminars in neonatology : SN.

[9]  E. Anday,et al.  Urinary Tract Infection With Trichomonas vaginalis in a Premature Newborn Infant and the Development of Chronic Lung Disease , 2003, Journal of Perinatology.

[10]  Y. Takei,et al.  A Case of Wilson-Mikity Syndrome With High Serum KL-6 Levels , 2003, Journal of Perinatology.

[11]  W. Northway.  Bronchopulmonary dysplasia: Thirty‐three years later , 2001, Pediatric pulmonology.

[12]  E. Bancalari.  Changes in the Pathogenesis and Prevention of Chronic Lung Disease of Prematurity , 2001, American journal of perinatology.

[13]  C. Peng,et al.  Chronic lung disease in extremely low birth weight infants: a two-year retrospective analysis. , 2000, Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi.

[14]  D. Phelps,et al.  Atypical Chronic Lung Disease Patterns in Neonates , 1999, Pediatrics.

[15]  H. Popper,et al.  Cytomegalovirus associated neonatal pneumonia and Wilson-Mikity syndrome: a causal relationship? , 1999, The European respiratory journal.

[16]  F. Ghezzi,et al.  The fetal inflammatory response syndrome. , 2007, American journal of obstetrics and gynecology.

[17]  A. Solimano,et al.  Chronic lung disease following neonatal ventilation. I. Incidence in two geographically defined populations , 1996, Pediatric pulmonology.

[18]  M. Nakayama,et al.  Chorioamnionitis and serum IgM in Wilson-Mikity syndrome. , 1989, Archives of disease in childhood.

[19]  A. Coates,et al.  Long-term pulmonary sequelae of the Wilson-Mikity syndrome. , 1978, The Journal of pediatrics.

[20]  P. Auld,et al.  CHRONIC PULMONARY INSUFFICIENCY OF PREMATURITY (CPIP) , 1974, Pediatric Research.

[21]  A. Levin,et al.  Pulmonary hypertension in the Wilson-Mikity syndrome. , 1972, The American journal of roentgenology, radium therapy, and nuclear medicine.

[22]  J. Hodgman,et al.  Chronic respiratory distress in the premature infant. Wilson-Mikity syndrome. , 1969, Pediatrics.

[23]  W. Northway,et al.  Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. , 1967, The New England journal of medicine.

[24]  M. Delivoria-Papadopoulos,et al.  The pulmonary syndrome of Wilson and Mikity. , 1965, Pediatrics.

[25]  M. Wilson,et al.  A new form of respiratory disease in premature infants. , 1960, A.M.A. journal of diseases of children.