Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.
暂无分享,去创建一个
Remo Hochstrasser | Rainer E. Martin | Horst Vogel | Rainer E Martin | Michael Werner | Christoph Kuratli | David Wechsler | Thilo Enderle | Alexander I Alanine | H. Vogel | R. Hochstrasser | A. Alanine | Michael Werner | Thilo Enderle | Christoph Kuratli | David Wechsler | T. Enderle
[1] A. Manz,et al. Revisiting lab-on-a-chip technology for drug discovery , 2012, Nature Reviews Drug Discovery.
[2] Flavien Susanne,et al. Continuous flow synthesis. A pharma perspective. , 2012, Journal of medicinal chemistry.
[3] Elizabeth Farrant,et al. Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery. , 2013, ACS medicinal chemistry letters.
[4] Elizabeth Farrant,et al. Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform. , 2013, Journal of medicinal chemistry.
[5] Leslie Y Yeo,et al. Microfluidic devices for bioapplications. , 2011, Small.
[6] Klavs F. Jensen,et al. The role of flow in green chemistry and engineering , 2013 .
[7] Steven V. Ley,et al. The flow synthesis of heterocycles for natural product and medicinal chemistry applications , 2011, Molecular Diversity.
[8] F. Pammolli,et al. The productivity crisis in pharmaceutical R&D , 2011, Nature Reviews Drug Discovery.
[9] Q. Fang,et al. Droplet-based microfluidic flow injection system with large-scale concentration gradient by a single nanoliter-scale injection for enzyme inhibition assay. , 2012, Analytical chemistry.
[10] D. Schlatter,et al. Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases* , 2002, The Journal of Biological Chemistry.
[11] Volker Hessel,et al. Novel process windows for enabling, accelerating, and uplifting flow chemistry. , 2013, ChemSusChem.
[12] O. Orwar,et al. Microfluidic gradient-generating device for pharmacological profiling. , 2005, Analytical chemistry.
[13] N. Allbritton,et al. Micro total analysis systems for cell biology and biochemical assays. , 2012, Analytical chemistry.
[14] Charles C. Persinger,et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge , 2010, Nature Reviews Drug Discovery.
[15] Paul Watts,et al. Continuous-flow organic synthesis: a tool for the modern medicinal chemist. , 2009, Future medicinal chemistry.
[16] M. Bunnage. Getting pharmaceutical R&D back on target. , 2011, Nature chemical biology.
[17] Andrew J deMello,et al. Micro- and nanofluidic systems for high-throughput biological screening. , 2009, Drug discovery today.
[18] G. Taylor. Dispersion of soluble matter in solvent flowing slowly through a tube , 1953, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.
[19] Hans-Joachim Böhm,et al. A guide to drug discovery: Hit and lead generation: beyond high-throughput screening , 2003, Nature Reviews Drug Discovery.
[20] Adam T. Melvin,et al. Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field. , 2013, Analytical chemistry.
[21] A. Griffiths,et al. High-resolution dose–response screening using droplet-based microfluidics , 2011, Proceedings of the National Academy of Sciences of the United States of America.
[22] Ian R. Baxendale,et al. The integration of flow reactors into synthetic organic chemistry , 2013 .
[23] Steven V. Ley,et al. Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography , 2013 .
[24] W. R. Kelly,et al. Determination of picogram quantities of Uranium in biological tissues by isotope dilution thermal ionization mass spectrometry with ion counting detection. , 1983, Analytical chemistry.
[25] Sindy K. Y. Tang,et al. Characterization of sensitivity and specificity in leaky droplet-based assays. , 2012, Lab on a chip.
[26] Mickael Montembault,et al. Leveraging the Advantages Offered by Microfluidics to Enhance the Drug Discovery Process , 2005 .
[27] Wolfgang Guba,et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. , 2013, Journal of medicinal chemistry.