Capsule endoscopy in Crohn's disease - Indications and reservations 2008.

Capsule endoscopy (CE) was found to be an effective tool in diagnosis of small bowel pathology. This review will focus on its role in Crohn's disease. Its role in patients with suspected Crohn's disease (CD) is described. CE has an established role for diagnosing CD when other tests are negative, though it is not a first line investigative tool in these patients. Over diagnosis is of concern. Its use in established CD remains an open question. It can provide exact mapping of small bowel disease before surgery, and might have impact on the treatment of the disease. It may have role in monitoring mucosal healing, which is becoming a target of therapy, and may help establish the exact diagnosis in a limited group of patients with indeterminate colitis. Retention of CE might occur. It is of low rate in patients with suspected CD and higher in patients with known CD but clinical obstruction is extremely rare. Economic considerations are a limit to a wider application of the CE.

[1]  G. Costamagna,et al.  Video Capsule Endoscopy in Patients With Known or Suspected Small Bowel Stricture Previously Tested With the Dissolving Patency Capsule , 2007, Journal of clinical gastroenterology.

[2]  E. Seidman,et al.  Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change , 2007, Alimentary pharmacology & therapeutics.

[3]  P. Rutgeerts,et al.  Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? , 2007, Gut.

[4]  S. Bar‐Meir.  Review article: capsule endoscopy – are all small intestinal lesions Crohn's disease? , 2006, Alimentary pharmacology & therapeutics.

[5]  E. Rondonotti,et al.  Use of the Given Patency System for the screening of patients at high risk for capsule retention. , 2006, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[6]  Chang Duck Kim,et al.  Analysis of Incomplete Small Bowel Investigation in Capsule Endoscopy , 2004 .

[7]  G. Eisen.  The economics of PillCam. , 2006, Gastrointestinal endoscopy clinics of North America.

[8]  D. Fischer,et al.  Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn's disease , 2003, European journal of gastroenterology & hepatology.

[9]  V. G. Rao,et al.  Safety and efficacy of the M2A patency capsule for diagnosis of critical intestinal patency: Results of a prospective clinical trial , 2007, Journal of gastroenterology and hepatology.

[10]  P. Mantry,et al.  What we have learned from 5 cases of permanent capsule retention. , 2006, Gastrointestinal endoscopy.

[11]  B. Lewis,et al.  ICCE consensus for capsule retention. , 2005, Endoscopy.

[12]  B. Lewis,et al.  Capsule Endoscopy Retention: Is it a Complication? , 2006, Journal of clinical gastroenterology.

[13]  Y Kopelman,et al.  Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy , 2003, Gut.

[14]  P. Desmond,et al.  Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn's disease. , 2005, Gastrointestinal endoscopy.

[15]  A Bellumat,et al.  Capsule endoscopy findings in patients with suspected Crohn's disease and biochemical markers of inflammation. , 2006, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[16]  P. Rogalla,et al.  Small bowel involvement in Crohn’s disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis , 2005, Gut.

[17]  G. Iddan,et al.  Wireless capsule endoscopy , 2003, Gut.

[18]  D. Heresbach,et al.  Wireless capsule endoscopy versus ileocolonoscopy for the diagnosis of postoperative recurrence of Crohn’s disease: a prospective study , 2006, Gut.

[19]  Video capsule endoscopy in inflammatory bowel disease 2005 , 2005, Current opinion in gastroenterology.

[20]  G. Liguori,et al.  Controlled study using wireless capsule endoscopy for the evaluation of the small intestine in chronic refractory pouchitis , 2007, Alimentary pharmacology & therapeutics.

[21]  J. Ryu,et al.  Abdominal pain accompanied by weight loss may increase the diagnostic yield of capsule endoscopy: A Korean multicenter study , 2006, Scandinavian journal of gastroenterology.

[22]  W. Tremaine.  Review article: indeterminate colitis – definition, diagnosis and management , 2006, Alimentary pharmacology & therapeutics.

[23]  L. Biancone,et al.  Wireless capsule endoscopy and small intestine contrast ultrasonography in recurrence of Crohn's disease , 2007, Inflammatory bowel diseases.

[24]  Tetsuya Nakamura,et al.  Successful retrieval of video capsule endoscopy retained at ileal stenosis of Crohn’s disease using double‐balloon endoscopy , 2006, Journal of gastroenterology and hepatology.

[25]  J. Galmiche,et al.  Value of wireless capsule endoscopy in patients with indeterminate colitis (inflammatory bowel disease type unclassified) , 2007, Inflammatory bowel diseases.

[26]  Shu-Dong Xiao,et al.  Capsule endoscopy in diagnosis of small bowel Crohn's disease. , 2004, World journal of gastroenterology.

[27]  S. Lal,et al.  Review article: intestinal failure , 2006, Alimentary pharmacology & therapeutics.

[28]  B. Thjódleifsson,et al.  A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. , 2005, Gastroenterology.

[29]  G. Gay,et al.  Clinical evaluation of the use of the M2A patency capsule system before a capsule endoscopy procedure, in patients with known or suspected intestinal stenosis. , 2005, Endoscopy.

[30]  W. Mow,et al.  Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[31]  J. Herrerias,et al.  Capsule Endoscopy in Patients with Suspected Crohn’s Disease and Negative Endoscopy , 2003, Endoscopy.

[32]  Amy K Hara,et al.  A Meta-Analysis of the Yield of Capsule Endoscopy Compared to Other Diagnostic Modalities in Patients with Non-Stricturing Small Bowel Crohn's Disease , 2006, The American Journal of Gastroenterology.

[33]  A. May,et al.  Extraction of Entrapped Capsules from the Small Bowel by Means of Push-and-Pull Enteroscopy with the Double-Balloon Technique , 2005, Endoscopy.

[34]  G Costamagna,et al.  A novel diagnostic tool for detecting functional patency of the small bowel: the Given patency capsule. , 2005, Endoscopy.

[35]  J. Barkin,et al.  Obscure gastrointestinal bleeding: diagnostic and therapeutic approach. , 2007, Journal of clinical gastroenterology.

[36]  J. Herrerias,et al.  The value of capsule endoscopy in pediatric patients with a suspicion of Crohn's disease. , 2004, Endoscopy.

[37]  E. Rondonotti,et al.  Complications, limitations, and failures of capsule endoscopy: a review of 733 cases. , 2005, Gastrointestinal endoscopy.

[38]  Alphonso Brown,et al.  The Risk of Retention of the Capsule Endoscope in Patients with Known or Suspected Crohn's Disease , 2006, The American Journal of Gastroenterology.

[39]  R. Kozarek,et al.  Acute symptomatic small bowel obstruction due to capsule impaction. , 2007, Gastrointestinal endoscopy.

[40]  Marco Pennazio,et al.  Literature review and recommendations for clinical application of small-bowel capsule endoscopy, based on a panel discussion by international experts , 2007 .

[41]  Douglas K Rex,et al.  Wireless Capsule Endoscopy Detects Small Bowel Ulcers in Patients With Normal Results From State of the Art Enteroclysis , 2003, American Journal of Gastroenterology.

[42]  A. May,et al.  Prospective multicenter trial of capsule endoscopy in patients with chronic abdominal pain, diarrhea and other signs and symptoms (CEDAP-Plus Study) , 2007, Endoscopy.

[43]  V. Pons Beltrán,et al.  Evaluation of postsurgical recurrence in Crohn's disease: a new indication for capsule endoscopy? , 2007, Gastrointestinal endoscopy.

[44]  M. Persico,et al.  Capsule endoscopy is safe and effective after small-bowel resection. , 2004, Gastrointestinal endoscopy.