l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism

[1]  C. Newgard,et al.  Metabolomics and Metabolic Diseases: Where Do We Stand? , 2017, Cell metabolism.

[2]  D. Hardie,et al.  The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels , 2016, Diabetes.

[3]  B. Viollet,et al.  AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes , 2013, PloS one.

[4]  J. Dyck,et al.  Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin , 2013, Nature Medicine.

[5]  F. Haj,et al.  Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. , 2013, American journal of physiology. Endocrinology and metabolism.

[6]  Choon Nam Ong,et al.  Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics. , 2013, The Journal of clinical endocrinology and metabolism.

[7]  V. Mootha,et al.  Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents , 2013, Pediatric obesity.

[8]  K. Guan,et al.  Amino acid signalling upstream of mTOR , 2013, Nature Reviews Molecular Cell Biology.

[9]  T. Lehtimäki,et al.  Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women , 2012, Diabetes Care.

[10]  C. Newgard.  Interplay between lipids and branched-chain amino acids in development of insulin resistance. , 2012, Cell metabolism.

[11]  A. Cherrington,et al.  Regulation of hepatic glucose uptake and storage in vivo. , 2012, Advances in nutrition.

[12]  B. Viollet,et al.  AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. , 2012, The Biochemical journal.

[13]  R. Gerszten,et al.  Targeted Metabolomics , 2012, Current protocols in molecular biology.

[14]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[15]  C. Kahn,et al.  Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism , 2011, PloS one.

[16]  T. Lindsten,et al.  Ammonia-induced autophagy is independent of ULK1/ULK2 kinases , 2011, Proceedings of the National Academy of Sciences.

[17]  V. Mootha,et al.  Metabolite profiles and the risk of developing diabetes , 2011, Nature Medicine.

[18]  Rahul C. Deo,et al.  Metabolic Signatures of Exercise in Human Plasma , 2010, Science Translational Medicine.

[19]  E. Mukai,et al.  Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice , 2010, Diabetologia.

[20]  B. Kahn,et al.  Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels* , 2010, The Journal of Biological Chemistry.

[21]  E. Tai,et al.  Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men , 2010, Diabetologia.

[22]  I. Niki,et al.  Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2. , 2009, Archives of biochemistry and biophysics.

[23]  William E. Kraus,et al.  Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women , 2009, Diabetes Care.

[24]  M. Zou,et al.  Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis , 2009, Molecular and Cellular Biology.

[25]  B. Viollet,et al.  AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives , 2009, Acta physiologica.

[26]  Svati H Shah,et al.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. , 2009, Cell metabolism.

[27]  W. Saris,et al.  Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients , 2008, Diabetologia.

[28]  Pengxiang She,et al.  Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. , 2007, Cell metabolism.

[29]  B. Viollet,et al.  Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders , 2006, The Journal of physiology.

[30]  B. Viollet,et al.  Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. , 2006, Endocrinology.

[31]  B. Viollet,et al.  5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. , 2006, Diabetes.

[32]  P. Patil,et al.  AICAR and hyperosmotic stress increase insulin-stimulated glucose transport. , 2005, Journal of applied physiology.

[33]  B. Viollet,et al.  Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. , 2005, Diabetes.

[34]  D. Wasserman,et al.  Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. , 2005, Diabetes.

[35]  S. Kimball,et al.  Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase* , 2004, Journal of Biological Chemistry.

[36]  I. Shiojima,et al.  Akt Activity Negatively Regulates Phosphorylation of AMP-activated Protein Kinase in the Heart* , 2003, Journal of Biological Chemistry.

[37]  S. Uchida,et al.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.

[38]  D. Sabatini,et al.  mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.

[39]  G. Shulman,et al.  Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. , 2001, Diabetes.

[40]  C. Kahn,et al.  Bidirectional modulation of insulin action by amino acids. , 1998, The Journal of clinical investigation.

[41]  C. V. Smith,et al.  Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice. , 1997, Toxicology and applied pharmacology.

[42]  J. Boyer,et al.  Effects of osmotic stresses on isolated rat hepatocytes. I. Ionic mechanisms of cell volume regulation. , 1990, The American journal of physiology.

[43]  B. Stoll,et al.  Hepatocyte heterogeneity in glutamate metabolism and bidirectional transport in perfused rat liver. , 1989, European journal of biochemistry.

[44]  Godfrey L. Smith,et al.  The effects of hypertonicity on tension and intracellular calcium concentration in ferret ventricular muscle. , 1987, The Journal of physiology.

[45]  D. Häussinger,et al.  Hepatocyte heterogeneity in ammonia metabolism: impairment of glutamine synthesis in CCl4 induced liver cell necrosis with no effect on urea synthesis. , 1984, Chemico-biological interactions.

[46]  P. Felig.  The glucose-alanine cycle. , 1973, Metabolism: clinical and experimental.

[47]  A. Meister,et al.  Regulation of rat liver glutamine synthetase: activation by alpha-ketoglutarate and inhibition by glycine, alanine, and carbamyl phosphate. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[48]  P. Felig,et al.  Plasma amino acid levels and insulin secretion in obesity. , 1969, The New England journal of medicine.

[49]  R. Wilkins,et al.  Changes in intracellular calcium concentration in response to hypertonicity in bovine articular chondrocytes. , 2004, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.