FROM THE UIVERSITY OF CALFORNIA , LOS ANGELES , SCHOOL OF MEDIC Influenza 1968-A 2 / Hong KongI 68 MODERATOR :

DR. ST. GEME: * We wish to present the tragic confrontation between a pregnant young woman and A2/HONG KONG/68 and in so doing correlate the clinical, radiographic, pathologic and virologic aspects of this epidemic viral infection. Later, we will plumb the tale more deeply and unfold our knowledge about the influenza virion and the various facets of resistance which are important to the host in this confrontation. As a brief prologue while setting the stage for the presentation of the case, I would like to review the "Recommendations for Influenza Immulization and Control in the Civilian Population -1965-66" which was published in July of 1965 in the Morbidity and Mortality Weekly Report (MMWR) of the National Communicable Disease Center. The high risk groups for influenza immunization included persons with chronic debilitating diseases of cardiovascular, bronchopulmonary, and metabolic nature, the elderly, and pregnant women. "It is to be noted that some mortality was observed among pregnant women

[1]  L. Saxén,et al.  Asian influenza during pregnancy and congenital malformations. , 2009, Acta pathologica et microbiologica Scandinavica.

[2]  H. A. Blough Rôle of the Surface State in the Development of Myxoviruses , 2008 .

[3]  R. W. Simpson Genetic Studies with Influenza A Virus , 2008 .

[4]  H. Westbury Newcastle disease virus: An evolving pathogen? , 2001, Avian pathology : journal of the W.V.P.A.

[5]  R. D. Barry The replication of influenza virus RNA. , 1975, The Journal of antimicrobial chemotherapy.

[6]  K. Wasserman,et al.  Lung lavage (alveolar washing) in alveolar proteinosis. , 1970, The American journal of medicine.

[7]  G. K. Hirst,et al.  The single- and double-stranded RNA's and the proteins of incomplete influenza virus. , 1969, Virology.

[8]  R. Webster,et al.  A common surface antigen in influenza viruses from human and avian sources. , 1968, The Journal of general virology.

[9]  T. Merigan,et al.  Interferon--1968. How much do we understand? , 1968, California medicine.

[10]  R. W. Simpson,et al.  Temperature-sensitive mutants of influenza A virus: isolation of mutants and preliminary observations on genetic recombination and complementation. , 1968, Virology.

[11]  R. Webster,et al.  Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutination proteins. , 1968, Virology.

[12]  G. K. Hirst,et al.  Polyacrylamide gel electrophoresis of influenza virus RNA. , 1968, Virology.

[13]  D. Nayak,et al.  Isolation and Partial Characterization of Nucleic Acid of Influenza Virus , 1967, Journal of virology.

[14]  D. B. Weinstein,et al.  The effect of vitamin A on myxoviruses. II. Alterations in the lipids of influenza virus. , 1967, Virology.

[15]  W. Robinson,et al.  On the structure and replication of influenza virus. , 1967, Journal of molecular biology.

[16]  R. W. Simpson,et al.  Influence of lipids on the viral phenotype. I. Interaction of myxoviruses and their lipid constituents with phospholipases. , 1966, Virology.

[17]  N. Ledinko Genetic recombination with poliovirus type 1. Studies of crosses between a normal horse serum-resistant mutant and several guanidine-resistant mutants of the same strain. , 1963, Virology.

[18]  M. Okuhira [Pathology of influenza]. , 1962, Nihon Densenbyo Gakkai zasshi.

[19]  A. Mannini,et al.  The effect of Asian influenza on the outcome of pregnancy, Baltimore, 1957-1958. , 1961, American journal of public health and the nation's health.

[20]  J. Hers,et al.  Broad aspects of the pathology and pathogenesis of human influenza. , 1961, The American review of respiratory disease.

[21]  R. Acheson MATERNAL INFLUENZA AND CONGENITAL DEFORMITIES , 1960 .

[22]  V. Coffey,et al.  Maternal influenza and congenital deformities: a prospective study. , 1959, Lancet.

[23]  H. Jacobziner,et al.  Maternal mortality in the epidemic of Asian influenza, New York City, 1957. , 1958, American journal of obstetrics and gynecology.

[24]  E. W. Shrigley Viral and Rickettsial Infections of Man , 1948, The Yale Journal of Biology and Medicine.

[25]  D. Nayak Influenza virus: structure, replication and defectiveness. , 1969, Federation proceedings.

[26]  D. Nayak,et al.  An intermediate in the replication of influenza virus RNA. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A. Granoff Heterozygosis and phenotypic mixing with Newcastle disease virus. , 1962, Cold Spring Harbor symposia on quantitative biology.

[28]  D. E. Rogers,et al.  Studies on influenza in the pandemic of 1957-1958. II. Pulmonary complications of influenza. , 1959, The Journal of clinical investigation.

[29]  R. Finkelstein,et al.  Viral inhibitors in normal animal sera. , 1958, Texas reports on biology and medicine.

[30]  P. Duesberg THE RNA'S OF INFLUENZA VIRUS* , 2022 .

[31]  F. Collins Influenza Occurring in Pregnant Women , 2022 .