TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis
暂无分享,去创建一个
Douglas Strathdee | Owen J. Sansom | Karen Blyth | Karen H. Vousden | O. Sansom | K. Vousden | K. Blyth | R. Ridgway | D. Strathdee | D. Athineos | E. Cheung | Pearl Lee | W. Lambie | C. Nixon | Eric C. Cheung | Rachel A. Ridgway | Colin Nixon | Dimitris Athineos | Pearl Lee | Wendy Lambie
[1] Eyal Gottlieb,et al. TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis , 2006, Cell.
[2] E. Schon,et al. Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. , 2010, Human molecular genetics.
[3] J. Steinbach,et al. Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis* , 2012, The Journal of Biological Chemistry.
[4] D. Winton,et al. Target cells for the cytotoxic effects of carcinogens in the murine small bowel. , 1992, Carcinogenesis.
[5] G. Riggins,et al. Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2 , 2012, Current opinion in oncology.
[6] Ian P Newton,et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. , 2004, Genes & development.
[7] Hanna Y. Irie,et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment , 2009, Nature.
[8] Jinsong Liu,et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. , 2006, Cancer cell.
[9] C. Thompson,et al. Glutamine addiction: a new therapeutic target in cancer. , 2010, Trends in biochemical sciences.
[10] Ralph J Deberardinis,et al. Brick by brick: metabolism and tumor cell growth. , 2008, Current opinion in genetics & development.
[11] R. Jaenisch,et al. A transgenic mouse strain expressing four drug-selectable marker genes. , 1997, Nucleic acids research.
[12] M. Murphy,et al. Mitochondrial thiols in antioxidant protection and redox signaling: distinct roles for glutathionylation and other thiol modifications. , 2012, Antioxidants & redox signaling.
[13] H. Clevers,et al. Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.
[14] L. Cantley,et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.
[15] Hans Clevers,et al. Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.
[16] E. White,et al. Immortalized mouse epithelial cell models to study the role of apoptosis in cancer. , 2008, Methods in enzymology.
[17] Reynaldo Sequerra,et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP , 2000, Nature Genetics.
[18] V. Costanzo,et al. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair , 2010, The EMBO journal.
[19] D. Albertson,et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability , 2005, Nature.
[20] J. López-Barneo,et al. The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia , 2004, Molecular and Cellular Biology.
[21] H. Cooper,et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. , 1993, Laboratory investigation; a journal of technical methods and pathology.
[22] O. Sansom,et al. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. , 2012, The Journal of clinical investigation.
[23] K. Vousden,et al. Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death , 2012, Proceedings of the National Academy of Sciences.
[24] Hans Clevers,et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. , 2011, Gastroenterology.
[25] Scott E. Kern,et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.
[26] W. Wheaton,et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.
[27] C. Nathan,et al. Production of large amounts of hydrogen peroxide by human tumor cells. , 1991, Cancer research.
[28] R. Hamanaka,et al. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. , 2010, Trends in biochemical sciences.
[29] L. Yin,et al. Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH. , 2012, Blood.
[30] C. Potten,et al. Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation , 1997, Oncogene.
[31] C. Thompson,et al. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. , 2009, Current opinion in genetics & development.
[32] L. Nutt,et al. Results Inhibition of NADPH production through the pentose phosphate pathway triggers apoptosis in Drosophila S 2 cells , 2010 .
[33] Gerald C. Chu,et al. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.
[34] N. Copeland,et al. A highly efficient recombineering-based method for generating conditional knockout mutations. , 2003, Genome research.
[35] B. Faubert,et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. , 2011, Genes & development.
[36] K. Vousden,et al. p53: new roles in metabolism. , 2007, Trends in cell biology.
[37] Chi V Dang,et al. Links between metabolism and cancer. , 2012, Genes & development.
[38] G. Reifenberger,et al. RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival , 2012, Oncogene.
[39] Julie A. Wilkins,et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. , 2010, Developmental cell.
[40] Youn Wha Kim,et al. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. , 2012, Human pathology.
[41] Alison Martin,et al. Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. , 2007, Cancer cell.
[42] J. Rogers,et al. A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction. , 2005, Genomics.
[43] Hans Clevers,et al. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. , 2009, Gastroenterology.
[44] T. Van Loy,et al. Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo , 2011, EMBO reports.
[45] Gavin Kelly,et al. Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. , 2012, Cancer discovery.
[46] J. Rabinowitz,et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation , 2012, Proceedings of the National Academy of Sciences.
[47] Hua Li,et al. Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)* , 2009, Journal of Biological Chemistry.
[48] A. Bradley,et al. Null and conditional semaphorin 3B alleles using a flexible puroΔtk loxP/FRT vector , 2005, Genesis.
[49] Kevin M. Ryan,et al. p53 and metabolism , 2009, Nature Reviews Cancer.
[50] Jason W. Locasale,et al. Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses , 2011, Science.
[51] Guido Kroemer,et al. Tumor cell metabolism: cancer's Achilles' heel. , 2008, Cancer cell.
[52] T. Mak,et al. Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.
[53] H. Clevers,et al. Single Lgr5 stem cells build cryptvillus structures in vitro without a mesenchymal niche , 2009, Nature.
[54] E. Koonin,et al. Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD , 2004, Science.
[55] A. Levine,et al. Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway , 2012, Cell.
[56] Wei Gu,et al. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence , 2012, Cell.
[57] K. Vousden,et al. Modulation of intracellular ROS levels by TIGAR controls autophagy , 2009, The EMBO journal.
[58] Gregory Stephanopoulos,et al. Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis , 2012, BMC Proceedings.
[59] Gong Yang,et al. Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer , 2005, Journal of Biological Chemistry.
[60] R. Frenkel. Regulation and physiological functions of malic enzymes. , 1975, Current topics in cellular regulation.