Tracking the Opioid Drug Overdose Epidemic in King County, Washington Using an Improved Methodology for Certifying Heroin Related Deaths

Guidelines of the National Association of Medical Examiners recommend that death certificates of overdose deaths list specific drugs. While this is important in tracking the national opioid drug overdose epidemic, differentiating heroin from morphine as the source drug remains problematic. To distinguish the two, a specific methodology was developed for death certification based on a combination of toxicology testing and scene investigation. This study evaluates the methodology in assessing the contribution of heroin. In two decades in King County, there were 3369 opioid drug overdose deaths, ranging from 139 in 1995 to 233 in 2014. In the 1990's, opioid overdose deaths were predominantly due to heroin; deaths due to prescription opioids were relatively uncommon. This trend reversed around 2003 with overdose deaths due to heroin declining and those due to prescription opioids increasing. The trend again reversed around 2012 with resurgence of heroin and declining deaths due to prescription opioids. Before the specific methodology was employed, it was known that heroin was the predominant opioid, but the summary data did not differentiate morphine and heroin. After adopting the methodology in 2004, the data reasonably tracked the contribution of heroin: out of 2125 opioid deaths, 34% were due to heroin, ranging from 14% in 2009 to 65% in 2014. The results of this study show an overall increase in opioid deaths and an inverse relationship between heroin and the prescription opioids. Furthermore, the specific methodology for certifying heroin deaths greatly improves accuracy in tracking opioid overdose deaths.

[1]  L. Paulozzi,et al.  Trends and characteristics of heroin overdoses in Wisconsin, 2003-2012. , 2015, Drug and alcohol dependence.

[2]  T. Farley,et al.  Decrease in Rate of Opioid Analgesic Overdose Deaths — Staten Island, New York City, 2011–2013 , 2015, MMWR. Morbidity and mortality weekly report.

[3]  Holly Hedegaard,et al.  Drug-poisoning deaths involving heroin: United States, 2000-2013. , 2015, NCHS data brief.

[4]  Christopher M. Jones,et al.  A comprehensive approach to address the prescription opioid epidemic in Washington State: milestones and lessons learned. , 2015, American journal of public health.

[5]  Leonard J Paulozzi,et al.  Prescription opioid analgesic use among adults: United States, 1999-2012. , 2015, NCHS data brief.

[6]  Svetla Slavova,et al.  Increases in Heroin Overdose Deaths — 28 States, 2010 to 2012 , 2014, Morbidity and Mortality Weekly Report.

[7]  Li Hui Chen,et al.  Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011. , 2014, NCHS data brief.

[8]  Thomas Gilson,et al.  The Cuyahoga County Heroin Epidemic , 2014 .

[9]  J. Glanz,et al.  National trends in pharmaceutical opioid related overdose deaths compared to other substance related overdose deaths: 1999-2009. , 2013, Drug and alcohol dependence.

[10]  Kurt B. Nolte,et al.  State Variation in Certifying Manner of Death and Drugs Involved in Drug Intoxication Deaths , 2013 .

[11]  D. Dolinak The Large Role of Prescription Drugs in Accidental Drug Deaths , 2013 .

[12]  G. Davis Recommendations for the Investigation, Diagnosis, and Certification of Deaths Related to Opioid Drugs , 2013 .

[13]  G. Davis,et al.  Complete Republication: National Association of Medical Examiners Position Paper: Recommendations for the Investigation, Diagnosis, and Certification of Deaths Related to Opioid Drugs , 2013, Journal of Medical Toxicology.

[14]  L. Paulozzi Prescription drug overdoses: a review. , 2012, Journal of safety research.

[15]  Laxmaiah Manchikanti,et al.  Opioid epidemic in the United States. , 2012, Pain physician.

[16]  L. Paulozzi,et al.  A Comparison of Florida Medical Examiners’ Reports and Death Certificates for Specific Drug Related Overdose Deaths , 2012 .

[17]  A. Christophersen,et al.  Morphine to codeine concentration ratio in blood and urine as a marker of illicit heroin use in forensic autopsy samples. , 2012, Forensic science international.

[18]  J. Turner,et al.  Bending the prescription opioid dosing and mortality curves: impact of the Washington State opioid dosing guideline. , 2012, American journal of industrial medicine.

[19]  J. Booth,et al.  The Predictive Value of History and Scene Investigation for Toxicology Results in a Medical Examiner Population , 2007, The American journal of forensic medicine and pathology.

[20]  A. Jones,et al.  Concentration ratios of morphine to codeine in blood of impaired drivers as evidence of heroin use and not medication with codeine. , 2001, Clinical chemistry.