A long-term survival case of small cell lung cancer in an HIV-infected patient.

We report a case of small cell lung cancer in a patient with human immunodeficiency virus (HIV) infection. The patient was a 51-year-old man diagnosed 8 years previously as seropositive for HIV, who was admitted to our hospital for re-evaluation of antiretroviral medications due to multidrug resistance. Chest radiograph revealed an abnormal hilar shadow subsequently confirmed to be small cell lung cancer. He received chemotherapy concurrently with highly active antiretroviral therapy (HAART), and lived for 14 months after the diagnosis. The prognosis of lung cancer in HIV-seropositive patients is very poor, and adverse effects of chemotherapy occur more frequently than in other patients. However, the simultaneous antiretroviral agents and combination chemotherapy was successful. Such treatment may be effective despite an otherwise poor prognosis, including HIV infection.

[1]  C. Diamond,et al.  Malignancy‐related causes of death in human immunodeficiency virus‐infected patients in the era of highly active antiretroviral therapy , 2005, Cancer.

[2]  P. Morlat,et al.  Malignancy-related causes of death in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy. , 2005, Cancer.

[3]  D. Costagliola,et al.  Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  Michael Simoff,et al.  Impact of comorbidity on lung cancer survival , 2003, International journal of cancer.

[5]  B. Gazzard,et al.  HIV-related lung cancer in the era of highly active antiretroviral therapy , 2003, AIDS.

[6]  D. Serraino,et al.  Lung carcinoma in 36 patients with human immunodeficiency virus infection , 2000, Cancer.

[7]  D. Greenblatt,et al.  Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with Ritonavir , 1998, Journal of clinical pharmacology.

[8]  S. Carozza,et al.  AIDS-related bronchogenic carcinoma: fact or fiction? , 1998, Chest.

[9]  M. Fukuoka,et al.  55 Phase II study of amrubicin (SM-5887), a novel 9-amino-anthracycline, in previously untreated patients with extensive-stage small-cell lung cancer (ES-SCLC): A trial of the west Japan lung cancer group , 1997 .

[10]  R. Vyzula,et al.  Lung cancer in patients with HIV-infection. , 1996, Lung cancer.

[11]  M. Loveless,et al.  Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors. , 1996, Blood.

[12]  J. Rankin,et al.  Acquired immune deficiency syndrome and the lung. , 1988, Chest.