Single-step multivalent capture assay for nucleic acid detection with dual-affinity regulation using mutation inhibition and allosteric activation† †Electronic supplementary information (ESI) available: Experimental procedures, table of detailed DNA sequences and supporting figures. See DOI: 10.1039

A single-step electrocatalytic biosensor with dual-affinity regulation enables a tunable dynamic range and tunable single nucleotide resolution for nucleic acid detection.

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