MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle‐dependent phosphorylation

Background: The RING finger proteins function in a variety of fundamental cellular processes. The products of some members of the Polycomb group (PcG) bear ring finger domains and are defined as a subclass of RING finger proteins. Among them are Drosophila posterior sex combs and suppressor 2 of zeste, whose RING fingers are conserved in vertebrate PcG proteins Mel18 and Bmi1.

[1]  P. Adler,et al.  In vivo assay for protein-protein interactions using Drosophila chromosomes , 1996, Chromosoma.

[2]  R. Paro,et al.  Mapping functional domains of the Polycomb protein ofDrosophila melanogaster , 1995, Chromosome Research.

[3]  M. Vidal,et al.  Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. , 2001, Development.

[4]  M. Fellous,et al.  NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system , 2001, Mechanisms of Development.

[5]  M. Vidal,et al.  Production of monoclonal antibodies against mammalian Ring1B proteins. , 2001, Hybridoma.

[6]  Hiroshi Matsui,et al.  HUNT: launch of a full-length cDNA database from the Helix Research Institute , 2001, Nucleic Acids Res..

[7]  Peter Jackson,et al.  The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. , 2000, Trends in cell biology.

[8]  A. Weissman,et al.  RING Finger Proteins Mediators of Ubiquitin Ligase Activity , 2000, Cell.

[9]  Simak Ali,et al.  Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7. , 2000, Molecular cell.

[10]  R. Pestell,et al.  Cell cycle regulation and RNA polymerase II. , 2000, Frontiers in bioscience : a journal and virtual library.

[11]  P. Freemont.  Ubiquitination: RING for destruction? , 2000, Current Biology.

[12]  J. Voncken,et al.  Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status. , 1999, Journal of cell science.

[13]  R. Kingston,et al.  Stabilization of Chromatin Structure by PRC1, a Polycomb Complex , 1999, Cell.

[14]  M. Vidal,et al.  RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1 , 1999, The EMBO journal.

[15]  P. Kaldis.  The cdk-activating kinase (CAK): from yeast to mammals , 1999, Cellular and Molecular Life Sciences CMLS.

[16]  K Kornfeld,et al.  Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. , 1999, Genes & development.

[17]  R. DePinho,et al.  The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus , 1999, Nature.

[18]  Arie P. Otte,et al.  RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity , 1999, Molecular and Cellular Biology.

[19]  A. Berns,et al.  Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. , 1999, Genes & development.

[20]  C. Hemenway,et al.  The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains , 1998, Oncogene.

[21]  V. Pirrotta,et al.  Polycombing the Genome: PcG, trxG, and Chromatin Silencing , 1998, Cell.

[22]  M. Kyba,et al.  The Drosophila Polycomb Group Protein Psc Contacts ph and Pc through Specific Conserved Domains , 1998, Molecular and Cellular Biology.

[23]  X. Chen,et al.  p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner , 1997, Molecular and cellular biology.

[24]  Mark J Alkema,et al.  MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. , 1997, Journal of molecular biology.

[25]  M. A. Motaleb,et al.  Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. , 1997, Development.

[26]  M. Vidal,et al.  Ring1A is a transcriptional repressor that interacts with the Polycomb‐M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain , 1997, The EMBO journal.

[27]  V. Pirrotta,et al.  Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. , 1997, Trends in genetics : TIG.

[28]  P. Chambon,et al.  Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7 , 1997, Cell.

[29]  L. Hu,et al.  The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. , 1997, Immunity.

[30]  V. Pirrotta,et al.  PcG complexes and chromatin silencing. , 1997, Current opinion in genetics & development.

[31]  Mark J Alkema,et al.  Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic , 2022 .

[32]  M. Aurrand-Lions,et al.  Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. , 1997, Development.

[33]  Mark J Alkema,et al.  Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. , 1997, Genes & development.

[34]  Nihon Hassei Seibutsu Gakkai,et al.  Genes to cells , 1996 .

[35]  M. Kitagawa,et al.  The consensus motif for phosphorylation by cyclin D1‐Cdk4 is different from that for phosphorylation by cyclin A/E‐Cdk2. , 1996, The EMBO journal.

[36]  C. Dang,et al.  Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity , 1996, Molecular and cellular biology.

[37]  Mark J Alkema,et al.  The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression , 1996, Mechanisms of Development.

[38]  M. Yaniv,et al.  The hbrm and BRG‐1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. , 1996, The EMBO journal.

[39]  P. Freemont,et al.  The RING finger domain: a recent example of a sequence-structure family. , 1996, Current opinion in structural biology.

[40]  E. Nigg.  Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? , 1996, Current opinion in cell biology.

[41]  R. Balling,et al.  A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. , 1996, Development.

[42]  I. Irminger-Finger,et al.  The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1. , 1995, Gene.

[43]  M. Bienz,et al.  Transcriptional silencing of homeotic genes in drosophila , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[44]  R. Paro,et al.  Propagating memory of transcriptional states. , 1995, Trends in genetics : TIG.

[45]  S. Elgin,et al.  Position effect variegation in Drosophila is associated with an altered chromatin structure. , 1995, Genes & development.

[46]  C.-ting Wu,et al.  A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster. , 1995, Genetics.

[47]  R. Paro,et al.  Chromatin multiprotein complexes involved in the maintenance of transcription patterns. , 1995, Current opinion in genetics & development.

[48]  石田 厚.  Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new "RING-finger" motif , 1995 .

[49]  J. Simon,et al.  Locking in stable states of gene expression: transcriptional control during Drosophila development. , 1995, Current opinion in cell biology.

[50]  J. Kennison.  The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. , 1995, Annual review of genetics.

[51]  J. Hoeijmakers,et al.  The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor , 1994, Cell.

[52]  M. Sofroniew,et al.  Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. , 1994, Genes & development.

[53]  R. Kingston,et al.  Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells , 1994, Molecular and cellular biology.

[54]  J. Labbé,et al.  The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin‐dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. , 1993, The EMBO journal.

[55]  T. Hunt,et al.  The cdc2‐related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. , 1993, The EMBO journal.

[56]  J. Harper,et al.  CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. , 1993, The EMBO journal.

[57]  Jonathan A. Cooper,et al.  Mammalian Ras interacts directly with the serine/threonine kinase raf , 1993, Cell.

[58]  V. Pirrotta,et al.  Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. , 1993, The EMBO journal.

[59]  D G Wilkinson,et al.  Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. , 1993, Methods in enzymology.

[60]  P. Freemont.  The RING finger. A novel protein sequence motif related to the zinc finger. , 1993, Annals of the New York Academy of Sciences.

[61]  R. Paro,et al.  Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. , 1992, The EMBO journal.

[62]  H. Brock,et al.  The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. , 1992, Genes & development.

[63]  M. Frasch,et al.  Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2 , 1991, Nature.

[64]  P. Adler,et al.  Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene , 1991, Nature.

[65]  H. Matsubara,et al.  Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. , 1990, The Journal of biological chemistry.

[66]  R. Paro,et al.  In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster , 1989, Nature.

[67]  K. Murata,et al.  Transformation of intact yeast cells treated with alkali cations. , 1984, Journal of bacteriology.

[68]  P. Sharp,et al.  In vitro transcription: whole-cell extract. , 1983, Methods in enzymology.

[69]  P. Y. Chou,et al.  Empirical predictions of protein conformation. , 1978, Annual review of biochemistry.