Kutane extramedulläre Hämatopoese bei idiopathischer Osteomyelofibrose

Cutaneous myelofibrosis with extramedullary hematopoiesis was detected in erythematous macules in the abdominal region of a 67-year-old woman. The infiltrates were composed of myeloic cells and CD-61-positive megacaryocytic series. Erythroid series were not found. During maintenance therapy with hydroxyurea, these eruptions developed eight months after electron beam radiation treatment. The skin lesions expanded to the proximal extremities but did not increase any more when the chronic myelogenous leukemia proceeded. Another electronic beam irradiation was considered, but the patient died from a blast crisis due to conversion into chronic myelogenous leukemia (CML).